Видання зареєстровані авторами шляхом самоархівування
Permanent URI for this communityhttps://devessuir.sumdu.edu.ua/handle/123456789/1
Browse
10 results
Search Results
Item Удосконалення управління недержавним медичним закладом в умовах конкуренції на ринку медичних послуг (на прикладі центру Еледія)(Сумський державний університет, 2022) Куц, Лариса Вікторівна; Куц, Лариса Викторовна; Kuts, Larysa ViktorivnaВ роботі розглянуто актуальний напрям в системі розвитку охорони здоров’я в Україні – підходи, механізми та технології оптимізації управління приватним медичним закладом в умовах конкуренції на ринку медичних послуг. Висвітлено підходи до оцінки конкурентоспроможності медичних закладів Проаналізовано міжнародний досвід підвищення конкурентоспроможності в недержавних медичних закладах. Проаналізовано специфіку діяльності та склад персоналу медичного центру Еледія. Надано аналіз конкурентного середовища на ринку медичних послуг м. Суми Визначено основні стратегії вдосконалення системи управління Центром Еледія для підвищення конкурентоспроможності. Надано науково обґрунтовані рекомендації щодо удосконалення управління недержавними медичними центрами в умовах конкуренції на ринку медичних послуг України. Доведено, що що в конкурентній боротьбі на локальному ринку медичних послуг головним джерелом конкурентних переваг є не цінова конкуренція, а пропозиція ексклюзивних та якісних послуг. В роботі доводиться, що конкуренція в системі охороні здоров'я служить механізмом, що сприяє підвищенню цінності та якості медичних послуг для пацієнтів.Item Revealing the molecular-genetic and clinical predictors of glucocorticoid resistance in patients with hand eczema(Aluna Publishing, 2022) Methkal, A.; Куц, Лариса Вікторівна; Куц, Лариса Викторовна; Kuts, Larysa ViktorivnaTo reveal the possible predictors of the glucocorticoid resistance in patients with hand eczema (HE) based on the demographic, clinical, and molecular-genetic data.Item Serum levels of IL-2 and IL-17A are related to clinical type and severity of alopecia areata(Aluna Publishing, 2022) Алджабалі, Мохаммад Ажар Мохаммад; Алджабали, Мохаммад Ожар Мохаммад; Aldzhabali, Mokhammad Azhar Mokhammad; Куц, Лариса Вікторівна; Куц, Лариса Викторовна; Kuts, Larysa ViktorivnaThe aim: To check the link between interleukins serum levels (IL-2, IL-10, IL-17A) and alopecia areata (AA) development, severity, and clinical course. Materials and methods: Totally 104 patients with AA and 30 matched control individuals were enrolled in the study. The serum levels of IL-2, IL-10, and IL-17A were evaluated in all participants. Severity of Alopecia Tool (SALT) was used to assess the AA severity. The SPSS 22.0 and Python environment were used for statistical analysis. Results: The comparative analysis has demonstrated that the serum levels of IL-2 and IL-17A in AA patients are higher than in controls (P = 0.008 and P = 0.013, respectively). The blood level of IL-2 in patients with AA depends on disease severity (P = 0.006) and clinical subtype (P = 0.016). The serum concentration of IL-17A was also associated with AA severity (P = 0.010) and subtype (P = 0.004). The positive correlation between SALT score and serum level of IL-17A (r = 0.33, P = 0.001) and IL-2 (r = 0.28, P = 0.004) was revealed. The strong positive correlation between IL-17A and IL-2 was also detected (r = 0.49, P < 0.001). There was no link between AA occurrence, manifestation and IL-10 amount. However, the weak negative correlation between SALT and IL-10 serum level was revealed (r = -0.20, P = 0.042). Conclusions: Our findings demonstrated that the serum levels of IL-2 and IL-17A are intercorrelated and associated with AA development, severity, and clinical type. The link between IL-10 serum level and AA was not detected.Item Dental status and oxidative homeostasis state in patients exposed to occupational vibration: superoxide dismutase and catalase content in oral fluid(Medpress, 2022) Cherkashyna, L.; Haidash, I.; Hlazkova, N.; Деміхова, Надія Володимирівна; Демихова, Надежда Владимировна; Demikhova, Nadiia Volodymyrivna; Shklyar, A.; Sukhonosov, R.; Barchan, G.; Куц, Лариса Вікторівна; Куц, Лариса Викторовна; Kuts, Larysa Viktorivna; Деміхов, Олексій Ігорович; Демихов, Алексей Игоревич; Demikhov, Oleksii IhorovychAim: The aim of the research involved determination of catalase and superoxide dismutase content in oral fluid of patients exposed to occupational vibration depending upon their dental status. Materials and methods: The assessment of dental status (DS) and superoxide dismutase (SOD) and catalase (CAT) content in oral fluid (OF) was performed in three groups of patients: control group (n0=129) included the persons exposed to occupational vibration and whose results of combined medical examination excluded the presence of vibration disease (VD); the second (n1=63 patients with VD stage I) and the third (n1=66 patients with VD stage II) groups consisted of the patients, who underwent treatment at the clinical department of the Research Institute of Occupational Hygiene and Occupational Diseases of Kharkiv National Medical University of the Ministry of Health of Ukraine. DS determination was carried out according to the method of K. M. Kosenko (Patent No. 57512, Ukraine) for in-patients and controls (during medical checkups) using the following indices: PMA, OHI-S, DMFT, with assessment of vacuum-pressory resistance of gingival capillaries (VPRC) (according to V. I. Kulazhenko) and community periodontal index of treatment needs (CPITN). SOD content was determined by the nonenzymatic method; CAT content was revealed spectrophotometrically. Primary data were statistically processed with the determination of accuracy by Student's test. Results: SOD content depending upon PMA intensity in VD patients ranged from 14.1±0.2 U/min to 15.7±0.5 U/min , was reliably (p<0.05) lower in patients with VD versus the controls (17.8±0.2 U/min and 14.2±0.2 U/min respectively, when PMA>2.1) and did not differ depending upon VD severity (15.7±0.5 U/min in VD stage I and 15.3±0.3 U/min in VD stage II, respectively). SOD content in OF in patients depending upon their OHI-S ranged from 13.5±0.3 U/min to 16.3±0.2 U/min and was reliably (p<0.05) lower in patients with OHI-S≥1.7 U. A comparative analysis showed that the activity of the enzymatic protection of the periodontal membrane could be also determined by the state of hard tissues, in particular by such DS index as DFTM. The activity of SOD in VD stage II was found to be reliably (p<0.05) reduced in patients with DFTM index exceeding 15 pts. A somewhat different pattern of SOD activity was found in OF in patients with VD stage I: SOD activity in OF was similar in all DFTM indices and it became reduced depending upon an increase of DFTM index. SOD content depending upon VPRC index in patients with VD ranged from 10.7±0.5 U/min to 16.8±0.3 U/min and was reliably (p<0.05) lower in cases with VPRC index ≤40 sec. CAT content depending upon PMA intensity in VD patients ranged from 4.6±0.4 U/min to 11.3±0.3 U/min and was reliably (p<0.05) higher in patients with VD stage I versus the controls and differed according to the severity. CAT content in OF in patients depending upon OHI-S ranged from 5.2±0.2 U/min to 10.1±0.3 U/min, was reliably (p<0.05) lower in cases with OHI-S ≥1.7 U, did not differ from the indices observed in the control group and was also found to be reliably lower in patients with VD stage II versus those with VD stage I (7.3±0.3 U/min and 8.6±0.2 U/min, respectively, when OHI-S ranged within 0.7÷1.6 U). CAT content in OF depending upon VPSC index in patients with VD ranged from 5.8±0.2 U/min to 8.6±0.6 U/min and was reliably (p<0.05) lower in cases with VPSC index ≤40 sec. Thus, CAT activity in OF in patients was reliably (p<0.05) reduced (in VPRC>40 sec it was equal to 7.8±0.2 U/min, and in VPRC≤40 sec it was 8.6±0.1 U/ min) in VD stage I with decreased VPRC. Conclusions: A trend (p>0.05) towards an increase in SOD activity in VD stage I versus the controls was revealed, whereas VD stage II demonstrated a reliable (p<0.05) reduction of the above activity. At the same time, an unsatisfactory state of oral hygiene was shown to promote inhibition of the enzymatic protection of their periodontal membrane in patients with VD stage I. A trend (p>0.05) towards an increase of SOD activity in VD stage I versus the controls was revealed, whereas VD stage II demonstrated a reliable (p<0.05) reduction of the above activity. The assessment carried out in cases requiring combined treatment with surgical or non-surgical debridement and also in patients with supraor subgingival dental calculus found out that SOD activity was reliably reduced only in cases with VD stage II. CAT activity assessment in OF in VD patients having different levels of CPITN showed that the above activity in persons requiring combined treatment (including prosthodontic treatment; CPITN≥3.1points) was markedly and reliably reduced. All the above facts determine peculiarities in oral treatment strategies for this group of patients.Item Феномен розацеа-приливів (теоретичні аспекти)(ДЗ "Дніпропетровська медична академія МОЗ України", 2021) Бочаров, В.А.; Бочарова, В.В.; Лебедюк, М.М.; Сарайрех, Анас Аталла Салем; Сарайрех, Анас Аталла Салем; Sarairekh, Anas Atalla Salem; Куц, Лариса Вікторівна; Куц, Лариса Викторовна; Kuts, Larysa ViktorivnaПроблема феноменов розацеа (розовых угрей), распространенного в мире дерматоза с невыясненными многочисленными аспектами этиопатогенеза, согласно решениям международных научных форумов, является перспективным направлением современных медицинских исследований. Целью работы стало теоретическое обоснование существенных особенностей механизмов возникновения, развития и клинических проявлений первых признаков розацеа у женщин репродуктивного возраста. Использование системного аналитического методологического и методического подхода оценки данных клинических и лабораторных обследований женщин, больных розацеа, проведенных в различных регионах мира, позволило установить первичность такого проявления дерматоза, как появление неожиданного ощущения приливов крови к ограниченным зонам лица, которые сопровождаются локальным покраснением и местным жаром соответствующего участка кожи и существенно отличаются от подобных приливов при других заболеваниях или синдромах (климакс, мигрень и др.). Установлено, что особенность взаимосвязи указанных клинических характеристик (от англ.: rush – прилив, ruddy – покраснение, rosacea – розовые угри, reproduce – репродуктивный возраст женщин, reaction – реакция) позволяет отметить первые признаки дерматоза, как присущий этому заболеванию феномен (Rush-Ruddy-Rosacea-Reproduce-Reaction, сокращенно – «5-R»), ключевой патофизиологической мишенью которого (как и заболевания в целом) является нарушение комплекса иерархически зависимых механизмов реализации эволюционно детерминированной мотивационной потребности обеспечения репродуктивной функции женского организма (как на уровне клеточных и экстрацеллюлярных структур яичников, так и на разных уровнях подкорковых образований и центров коры больших полушарий головного мозга). Феномен розацеа-приливов тесно связан с другими феноменами этого дерматоза – гиперчувствительностью брадикининових рецепторов, актиническим эластозом, развитием послеэритемных телеангиэктазий. Перспективой дальнейших исследований проблемы розацеа является изучение взаимосвязей нарушений в функциональных системах молекул сигнальных соединений различных классов (гормонов, эйкозаноидов, нейропептидов, кининов, цитокинов и других) в патогенезе заболевания.Item Cholinesterase in different types of the muscle tissue during the early postmortem period for diagnosis of death coming(Bangladesh Academy of Sciences, 2021) Cherkashyna, L.; Shklyar, A.; Sukhonosov, R.; Miroshnikova, O.; Naguta, L.; Olkhovskiy, V.; Деміхова, Надія Володимирівна; Демихова, Надежда Владимировна; Demikhova, Nadiia Volodymyrivna; Куц, Лариса Вікторівна; Куц, Лариса Викторовна; Kuts, Larysa Viktorivna; Barchan, G.; Sukhomlyn, G.; Кіптенко, Людмила Іванівна; Киптенко, Людмила Ивановна; Kiptenko, Liudmyla IvanivnaThe purpose of the research: consisted in study of postmortem regularitiesin the content of cholinesterase in different types of muscle tissue (MT) for improving accuracy of determination of the prescription of death coming PDC.Materials and methods: The activity/level of cholinesterase was determined in homogenates of the myocardial (MMH), oesophageal (OMH), diaphragm (DMH) and intercostal muscles (IMH)within the early PMP (3-13 hours after the coming of death) on 30 human corpses. MT was sampled in conditions of postmortem biopsy with use of special instruments; MT homogenates were prepared following the standard technique with subsequent determination of cholinesterase content in MT homogenates. Results and discussion: The analysis of postmortem changes in the content of cholinesterase in MT depending upon PDC revealed that after 3 hours from the moment of death coming its highest content was in muscles of the oesophagus, the least one being in MT of the intercostal muscles (respectively, (2,717.1±37.1) and (883.5±6.2) U/g, р<0.001). Levels of cholinesterase content in MT of the myocardium and diaphragm were rather close, though they differed (respectively, (1,213.8±8.8) and (1,512.8±11.5) U/g, р<0.05), and occupied an intermediate place between the corresponding values of MT of the intercostal muscles and oesophagus.A common pattern for the content of cholinesterase in different types of MT was characterized by a decrease of this content with an increase in PDC terms; besides, the dynamic lines of its changes, that we obtained, became basic ones for substantiating quantitative time dependencies and construction of relevant nomograms for forensic diagnosis of PDC by cholinesterase content in MT. Conclusions: It was proved that the content of cholinesterase in all MT homogenates, which we studied, changed regularly (and nonlinearly), but the initial and final levels of cholinesterase content differed depending upon the type of MT. Besides, the dynamics in changes of the content of cholinesterase within the time period of 3÷13 hours from the moment of death coming differed upon the type of MT too. Advantages of the technique consist in theintegrity of biochemical examination of different types of MT and simplicity in interpretation of findings. The application of the nomogram technique for assessing PDC by cholinesterase content in MT makes it possible to improve the accuracy of diagnosis for terms of the coming of death up to 60 minutes.Item Arterial hypertension prevention as an actual medical and social problem(Ibn Sina Medical College, 2020) Деміхов, Олексій Ігорович; Демихов, Алексей Игоревич; Demikhov, Oleksii Ihorovych; Дегтярьова, Ія Олександрівна; Дегтярева, Ия Александровна; Dehtiarova, Iia Oleksandrivna; Rud, O.; Khotyeev, Y.; Куц, Лариса Вікторівна; Куц, Лариса Викторовна; Kuts, Larysa Viktorivna; Cherkashyna, L.; Деміхова, Надія Володимирівна; Демихова, Надежда Владимировна; Demikhova, Nadiia Volodymyrivna; Орловський, Олександр Вікторович; Орловский, Александр Викторович; Orlovskyi, Oleksandr ViktorovychSocial changes, technological re-equipment, intensive formation of urban infrastructure have led to a constant increase in stress factors and an excessive growth of the nervous and psychological population burden. As a result of these processes in economically developed countries, acute diseases are becoming less and less significant, unlike the group of chronic disorders, such as arterial hypertension. Data from the review of the literature and the data we have received indicate that there is an increase in the level of cortisol in the blood in the phase of anxiety, which reduces in the resistance phase. A significant role is played by another hormone - insulin, which plays a key role in the development of the general adaptive syndrome. Through it the body implements numerous counter-defects in relation to the regulatory influence of catecholamines and cortisol. In conditions of prolonged stress, the level of insulin in the blood decreases and diabetes develops. The effect of cortisol and catecholamines in the resistance phase persists. The level of oxidative modification of blood plasma proteins indices depends on the behavior of the individual and changes in his psycho-emotional state, while a prolonged increase in the levels of catecholamines and cortisol in peripheral blood causes the development of psychosomatic pathology. It is proved that under the influence of complex action of risk factors there are significant changes in the psycho-emotional state that cause hypertension. This is confirmed by the presence of the highest level of reactive anxiety in patients with hypertension of the 1st stage on the background of the lowest personal anxiety which is the basis for the occurrence of the disease. With the progression of hypertension there are more profound changes in the personality of the patient, which is accompanied by the accumulation of personal anxiety, which can lead to a depressive state of neurotic genesis, which we observed with its complication. On the basis of a comprehensive study, the effect of stress on the occurrence of a syndrome of psychoemotional stress is shown, which leads to a steady increase in blood pressure - hypertension, and with its subsequent action complicates its course.Item Патофізіологічні механізми псоріатичних феноменів(Сумський державний університет, 2013) Куц, Лариса Вікторівна; Куц, Лариса Викторовна; Kuts, Larysa ViktorivnaНайбільш характерними клінічними проявами псоріазу є його феномени (Кебнера та тріада Аушпіца). Феномен Кебнера виявляється в місцях, що частіше за все підлягають механічним подразненням або пошкодженням (лікті, коліна). Найбільш важливими патофізіологічними порушеннями, що характеризують феномен «стеаринової плями», є пара- та гіперкератоз, «термінальної плівки» – зміни в базальній мембрані, «кров’яної роси» – зміни в капілярах сосочків дерми. При цитуванні документа, використовуйте посилання http://essuir.sumdu.edu.ua/handle/123456789/32931Item Ревматоидный фактор как один из механизмов защиты организма при иммунокомплексных заболеваниях(Изд-во СумГУ, 2011) Куц, Лариса Вікторівна; Куц, Лариса Викторовна; Kuts, Larysa ViktorivnaItem Цитокіновий статус хворих на атопічний дерматит(Видавництво СумДУ, 2004) Бочаров, Василь Андрійович; Бочаров, Василий Андреевич; Bocharov, Vasyl Andriiovych; Куц, Лариса Вікторівна; Куц, Лариса Викторовна; Kuts, Larysa Viktorivna