Видання зареєстровані авторами шляхом самоархівування
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Item The Remodeling of Lungs Under the Influence of Alloxan-Induced Hyperglycemia("Carol Davilla" University of Medicine and Pharmacy, 2020) Теслик, Тетяна Петрівна; Teslyk, Tetiana Petrivna; Ярмоленкo, Ольга Сергіївна; Yarmolenkо, Olha Serhiivna; Бумейстер, Валентина Іванівна; Bumeister, Valentyna Ivanivna; Деміхова, Надія Володимирівна; Demikhova, Nadiia Volodymyrivna; Приходько, Ольга Олексіївна; Prykhodko, Olha Oleksiivna; Дмитрук, Сергій Миколайович; Dmytruk, Serhii Mykolaiovych; Dehtyarova, І.Diabetes mellitus is a global medical and social problem. 2-3% of the population suffers from diabetes mellitus. According to current forecasts, the number of people with diabetes mellitus will double every 15 years. Diabetes mellitus is the basis for the development of complex comorbidities and complications such as diabetic microangiopathy and neuropathy. Diabetes patients are at increased risk for atherosclerosis, coronary heart disease, and renal failure. Scientists around the world have been thoroughly engaged in the problem of hyperglycemia, which is the consequence of type 1 diabetes mellitus, but the causes of its occurrence have not been fully established yet. The study aimed to investigate the lungs of pre-reproductive age rats under the influence of alloxan-induced hyperglycemia.Item Management aspects of children's health: dysplastic-dependent pathology of the bronchopulmonary system and ecological heterogeneity of the environment(Azerbaijan Medical Journal, 2022) Деміхов, Олексій Ігорович; Demikhov, Oleksii Ihorovych; Dehtyarova, I.; Motrechko, V.; Коленко, Оксана Іванівна; Kolenko, Oksana Ivanivna; Yurchenko, Alla Vladyslavivna; Юрченко, Алла Владиславівна; Деміхова, Надія Володимирівна; Demikhova, Nadiia Volodymyrivna; Kroitor, V.Population stratification of the pediatric population was performed in the study, taking into account a set of regional-ecological factors relevant for the assessment of the health of children with dysplastic-dependent pathology of the bronchopulmonary system. The study was conducted using methods of systematic population modeling of a multi-factorial public health system under the influence of regional and ecologic factors. For each of the 30 environmental factors we have studied, its prognostic value, pathometric and sanologic value have been determined, which ensured the performance of population-personalized risk assessment of the dysplastic-dependent pathology of the bronchopulmonary system.A new methodology for environmental quality assessment has been substantiated, proposed and tested, the application of which allows to determine the differentiation of regional preventive programs of bronchopulmonary dysplasia and the dysplastic-dependent pathology of the bronchopulmonary system in childhood. Personalized regional population stratification of children with bronchopulmonary dysplasia and the dysplastic-dependent pathology of the bronchopulmonary system were performed, and regional clusters (administrative districts of the regions) were identified with an alternative level of environmental quality. The use of pathometric and sanometric assessments (different levels) of environmental factors can be significant to substantiate the structure of targeted health, social, and regional environmental programs for promoting the health of the pediatric population.Item Theoretical and methodological principles of providing medical and psychological assistance in the conditions of armed conflicts: experience for Ukraine(Primmate, 2022) Korylchuk, N.; Vlasenko, I.; Livandovska, I.; Бокова, Світлана Іванівна; Bokova, Svitlana Ivanivna; Деміхова, Надія Володимирівна; Demikhova, Nadiia VolodymyrivnaThe war in Ukraine opened up the problem of not only physical, but also psychological rehabilitation of its victims. The purpose of the article is to analyze the theoretical and methodological principles of providing medical and psychological assistance in the conditions of armed conflicts. The implementation of this task is based on the use of general scientific (analysis, synthesis, induction and deduction) and special (historical, comparative) research methods. The results analyzed primarily the Israeli strategy of medical and psychological assistance to the victims, since the Israeli army has a long experience of conducting combat operations, so it also has a strategy of helping to overcome psychological and mental disorders. Also, the peculiarities of psychological assistance in the armies of NATO countries crystallized since many new members of the Alliance belonged to the socialist bloc. It has been proven that it is important not only to provide assistance to the servicemen themselves but also to their family members, including by involving modern pharmacological means. The conclusions also emphasize the American experience, in particular, the fact that much attention is paid in the USA to the prevention of psychological disorders.Item The remodeling of lungs under the influence of alloxan-induced hyperglycemia(Sanatatea Press Group on behalf of the Romanian Society of Diabetes Nutrition and Metabolic Diseases, 2020) Теслик, Тетяна Петрівна; Teslyk, Tetiana Petrivna; Ярмоленкo, Ольга Сергіївна; Yarmolenkо, Olha Serhiivna; Бумейстер, Валентина Іванівна; Bumeister, Valentyna Ivanivna; Деміхова, Надія Володимирівна; Demikhova, Nadiia Volodymyrivna; Приходько, Ольга Олексіївна; Prykhodko, Olha Oleksiivna; Дмитрук, Сергій Миколайович; Dmytruk, Serhii Mykolaiovych; Dehtyarova, I.Introduction: Diabetes mellitus is a global medical and social problem. 2-3% of the population suffers from diabetes mellitus. According to current forecasts, the number of people with diabetes mellitus will double every 15 years. Diabetes mellitus is the basis for the development of complex comorbidities and complications such as diabetic microangiopathy and neuropathy. Diabetes patients are at increased risk for atherosclerosis, coronary heart disease, and renal failure. Scientists around the world have been thoroughly engaged in the problem of hyperglycemia, which is the consequence of type 1 diabetes mellitus, but the causes of its occurrence have not been fully established yet. The study aimed to investigate the lungs of pre-reproductive age rats under the influence of alloxan-induced hyperglycemia. Material and Methods: 12 rats of 3 months of age were involved in the experiment. They were divided into two series: experimental and control. The Control series includes six intact rats. For the experimental modeling of hyperglycemia, we used alloxan monohydrate, pre-dissolved in 0.9% solution of sodium chloride, which was then injected intraperitoneally once at a dose of 20 mg/100 g on an empty stomach. The experiment lasted 60 days. We measured the glucose level using the Accu-Chek Advantage (Boehringer, Germany) at2, 12, and 24 hours after alloxan injection, and then weekly. The average level of glucose in the blood remained at 11 mmol/L ± 2 mmol/L. To study the remodeling of the lungs, we used the histological examination by a light microscope (Olympus BH-2) and histomorphometry using the universal certified program “SEO Scan Lab 2.0” and “SEO Image Lab 2.0”. The obtained data were processed on a personal computer using the software “GraphPad” and a licensed Excel XP spreadsheet editor (Microsoft Office 2013). The data were analyzed by unpaired t-test. P values ≤0.05 were considered as statistically significant. Results: Obtained morphometric data shows the increase of the width of alveoli by 8.5% (p < 0.05), the width of the conducting part of the respiratory bronchiole by 15.7 % (p < 0.05) and the thickness of the interalveolar septum by 8.3% (p < 0.05). The wall thickness of pulmonary vessels increased by 22.9% (p <0.05). Lymphoid nodules were more hypertrophied compared to the control ones by 2.4 times (p <0.05). Conclusions: Alloxan-induced hyperglycemia leads to the development of emphysematous changes in combination with restriction. The vascular wall of muscular pulmonary vessels was thickened due to hypertrophy of the tunica media and tunica externa. The hypertrophy of lymphoid follicles and lymph nodes of the upper and lower mediastinum was observed in experimental animals.Item A digital transformation into occupational health and safety systems: a review of the best practices in Europe(Estonian University of Life Sciences, 2023) Деміхов, Олексій Ігорович; Демихов, Алексей Игоревич; Demikhov, Oleksii Ihorovych; Опанасюк, Юлія Анатоліївна; Опанасюк, Юлия Анатольевна; Opanasiuk, Yuliia Anatoliivna; Деміхова, Надія Володимирівна; Демихова, Надежда Владимировна; Demikhova, Nadiia Volodymyrivna; Merisalu, Е.Цифровізація активно поширюється і широко впроваджується в системах охорони праці (OHS). Прогресивні технології дозволяють ефективно впроваджувати цифрові системи у всіх елементах циклу управління – від планування до моніторингу, оцінки та рішень у різних секторах економіки. Цілься. Мета статті – дати огляд поточного стану цифрової трансформації в політиці гігієни праці європейських країн та України та визначити позитивні та негативні аспекти цифровізації в системах управління охороною праці. метод. Огляд базується на повних дослідницьких статтях, звітах і матеріалах конференцій у Scopus, Web of Science і базі даних Google Scholar, де ключові слова «оцифрування», «гігієна праці», «безпека», «роботи» та «системи управління» для літератури пошук використовували. Результати. Загалом було проаналізовано 51 джерело, включаючи 23 повні дослідницькі статті та 28 публікацій від EU-OSHA, МОП та ОЕСР. Формування бази даних і використання систем великих даних та інструментів контролю для моніторингу та оцінки робочого середовища, цифрових інструкцій, законодавства та платформ електронного навчання є основними цифровими інструментами в системах управління охороною праці. Використання програм навігатора на робочому місці допомагає зібрати необхідну інформацію та внести правильні норми в закон. Застосування нових цифрових технологій дозволяє ефективніше виконувати функції інспекції охорони праці, обслуговування та запобігання ризикам, а також зменшити виробничі травми та захворювання. Висновки. Нова ідеологія державної політики щодо розробки цифрових систем управління охороною праці (DOHSS) зробить ефективними рішення, засновані на фактичних даних, і досягне високих стандартів безпеки, а також стимулюватиме зростання бізнесу окремих галузей на національному та європейському рівнях. Кращий європейський досвід цифрової трансформації в системи управління охороною праці може бути впроваджений і в Україні.Item Correction of myocardial changes on an animal experimental model with meldonim(Oxford University Press, 2022) Ярмоленкo, Ольга Сергіївна; Ярмоленко, Ольга Сергеевна; Yarmolenkо, Olha Serhiivna; Бумейстер, Валентина Іванівна; Бумейстер, Валентина Ивановна; Bumeister, Valentyna Ivanivna; Приходько, Ольга Олексіївна; Prykhodko, Olha Oleksiivna; Гордієнко, Олена Володимирівна; Гордиенко, Елена Владимировна; Hordiienko, Olena Volodymyrivna; Деміхова, Надія Володимирівна; Демихова, Надежда Владимировна; Demikhova, Nadiia VolodymyrivnaProlonged hypoosmolar overhydration causes a volume overload necessitating cardioprotectors together with a complex of measures aimed at stabilizing the water and electrolyte balance. The content of water and electrolytes in the human body changes throughout life, so the body's response to the disorder of water and salt balance may be different depending on age. The fluid overload positively correlates with adverse outcomes in critically ill patients. One of the main tasks of modern cardiology is to find the means of leveling the influence of adverse factors on myocardium in different aged patients. The aim of our study was the determination of morphological changes in the myocardium of old laboratory animals under the influence of severe hypoosmolar hyperhydration and attempt to correct the identified changes by means of meldonium.Item Aspects of somatogenic asthenic syndrome in patients with high cardiovascular risk(Oxford University Press, 2022) Деміхов, Олексій Ігорович; Демихов, Алексей Игоревич; Demikhov, Oleksii Ihorovych; Деміхова, Надія Володимирівна; Демихова, Надежда Владимировна; Demikhova, Nadiia Volodymyrivna; Руденко, Тетяна Миколаївна; Руденко, Татьяна Николаевна; Rudenko, Tetiana Mykolaivna; Орловський, Олександр Вікторович; Орловский, Александр Викторович; Orlovskyi, Oleksandr ViktorovychAim: To study frequency and nature of psychopathological symptoms in various forms of somatogenic asthenic syndrome in patients with high cardiovascular risk (CVR). Methods: The quantitative anamnestic analysis of medical history, the variational statistics, the probabilistic allocation of clinical signs with estimation of reliability of the results. Among the 199 persons with high CVR and non-psychotic mental disorders: 31 patients had somatogenic asthenic syndrome (SAS), stratified by clinical variants: asthenic (1n2=14); asthenic-anxious (2n2=8); asthenic-subdepressive (3n2=6) and dyssomniac (4n2=3).Item Dental status and oxidative homeostasis state in patients exposed to occupational vibration: superoxide dismutase and catalase content in oral fluid(Medpress, 2022) Cherkashyna, L.; Haidash, I.; Hlazkova, N.; Деміхова, Надія Володимирівна; Демихова, Надежда Владимировна; Demikhova, Nadiia Volodymyrivna; Shklyar, A.; Sukhonosov, R.; Barchan, G.; Куц, Лариса Вікторівна; Куц, Лариса Викторовна; Kuts, Larysa Viktorivna; Деміхов, Олексій Ігорович; Демихов, Алексей Игоревич; Demikhov, Oleksii IhorovychAim: The aim of the research involved determination of catalase and superoxide dismutase content in oral fluid of patients exposed to occupational vibration depending upon their dental status. Materials and methods: The assessment of dental status (DS) and superoxide dismutase (SOD) and catalase (CAT) content in oral fluid (OF) was performed in three groups of patients: control group (n0=129) included the persons exposed to occupational vibration and whose results of combined medical examination excluded the presence of vibration disease (VD); the second (n1=63 patients with VD stage I) and the third (n1=66 patients with VD stage II) groups consisted of the patients, who underwent treatment at the clinical department of the Research Institute of Occupational Hygiene and Occupational Diseases of Kharkiv National Medical University of the Ministry of Health of Ukraine. DS determination was carried out according to the method of K. M. Kosenko (Patent No. 57512, Ukraine) for in-patients and controls (during medical checkups) using the following indices: PMA, OHI-S, DMFT, with assessment of vacuum-pressory resistance of gingival capillaries (VPRC) (according to V. I. Kulazhenko) and community periodontal index of treatment needs (CPITN). SOD content was determined by the nonenzymatic method; CAT content was revealed spectrophotometrically. Primary data were statistically processed with the determination of accuracy by Student's test. Results: SOD content depending upon PMA intensity in VD patients ranged from 14.1±0.2 U/min to 15.7±0.5 U/min , was reliably (p<0.05) lower in patients with VD versus the controls (17.8±0.2 U/min and 14.2±0.2 U/min respectively, when PMA>2.1) and did not differ depending upon VD severity (15.7±0.5 U/min in VD stage I and 15.3±0.3 U/min in VD stage II, respectively). SOD content in OF in patients depending upon their OHI-S ranged from 13.5±0.3 U/min to 16.3±0.2 U/min and was reliably (p<0.05) lower in patients with OHI-S≥1.7 U. A comparative analysis showed that the activity of the enzymatic protection of the periodontal membrane could be also determined by the state of hard tissues, in particular by such DS index as DFTM. The activity of SOD in VD stage II was found to be reliably (p<0.05) reduced in patients with DFTM index exceeding 15 pts. A somewhat different pattern of SOD activity was found in OF in patients with VD stage I: SOD activity in OF was similar in all DFTM indices and it became reduced depending upon an increase of DFTM index. SOD content depending upon VPRC index in patients with VD ranged from 10.7±0.5 U/min to 16.8±0.3 U/min and was reliably (p<0.05) lower in cases with VPRC index ≤40 sec. CAT content depending upon PMA intensity in VD patients ranged from 4.6±0.4 U/min to 11.3±0.3 U/min and was reliably (p<0.05) higher in patients with VD stage I versus the controls and differed according to the severity. CAT content in OF in patients depending upon OHI-S ranged from 5.2±0.2 U/min to 10.1±0.3 U/min, was reliably (p<0.05) lower in cases with OHI-S ≥1.7 U, did not differ from the indices observed in the control group and was also found to be reliably lower in patients with VD stage II versus those with VD stage I (7.3±0.3 U/min and 8.6±0.2 U/min, respectively, when OHI-S ranged within 0.7÷1.6 U). CAT content in OF depending upon VPSC index in patients with VD ranged from 5.8±0.2 U/min to 8.6±0.6 U/min and was reliably (p<0.05) lower in cases with VPSC index ≤40 sec. Thus, CAT activity in OF in patients was reliably (p<0.05) reduced (in VPRC>40 sec it was equal to 7.8±0.2 U/min, and in VPRC≤40 sec it was 8.6±0.1 U/ min) in VD stage I with decreased VPRC. Conclusions: A trend (p>0.05) towards an increase in SOD activity in VD stage I versus the controls was revealed, whereas VD stage II demonstrated a reliable (p<0.05) reduction of the above activity. At the same time, an unsatisfactory state of oral hygiene was shown to promote inhibition of the enzymatic protection of their periodontal membrane in patients with VD stage I. A trend (p>0.05) towards an increase of SOD activity in VD stage I versus the controls was revealed, whereas VD stage II demonstrated a reliable (p<0.05) reduction of the above activity. The assessment carried out in cases requiring combined treatment with surgical or non-surgical debridement and also in patients with supraor subgingival dental calculus found out that SOD activity was reliably reduced only in cases with VD stage II. CAT activity assessment in OF in VD patients having different levels of CPITN showed that the above activity in persons requiring combined treatment (including prosthodontic treatment; CPITN≥3.1points) was markedly and reliably reduced. All the above facts determine peculiarities in oral treatment strategies for this group of patients.Item Cholinesterase in different types of the muscle tissue during the early postmortem period for diagnosis of death coming(Bangladesh Academy of Sciences, 2021) Cherkashyna, L.; Shklyar, A.; Sukhonosov, R.; Miroshnikova, O.; Naguta, L.; Olkhovskiy, V.; Деміхова, Надія Володимирівна; Демихова, Надежда Владимировна; Demikhova, Nadiia Volodymyrivna; Куц, Лариса Вікторівна; Куц, Лариса Викторовна; Kuts, Larysa Viktorivna; Barchan, G.; Sukhomlyn, G.; Кіптенко, Людмила Іванівна; Киптенко, Людмила Ивановна; Kiptenko, Liudmyla IvanivnaThe purpose of the research: consisted in study of postmortem regularitiesin the content of cholinesterase in different types of muscle tissue (MT) for improving accuracy of determination of the prescription of death coming PDC.Materials and methods: The activity/level of cholinesterase was determined in homogenates of the myocardial (MMH), oesophageal (OMH), diaphragm (DMH) and intercostal muscles (IMH)within the early PMP (3-13 hours after the coming of death) on 30 human corpses. MT was sampled in conditions of postmortem biopsy with use of special instruments; MT homogenates were prepared following the standard technique with subsequent determination of cholinesterase content in MT homogenates. Results and discussion: The analysis of postmortem changes in the content of cholinesterase in MT depending upon PDC revealed that after 3 hours from the moment of death coming its highest content was in muscles of the oesophagus, the least one being in MT of the intercostal muscles (respectively, (2,717.1±37.1) and (883.5±6.2) U/g, р<0.001). Levels of cholinesterase content in MT of the myocardium and diaphragm were rather close, though they differed (respectively, (1,213.8±8.8) and (1,512.8±11.5) U/g, р<0.05), and occupied an intermediate place between the corresponding values of MT of the intercostal muscles and oesophagus.A common pattern for the content of cholinesterase in different types of MT was characterized by a decrease of this content with an increase in PDC terms; besides, the dynamic lines of its changes, that we obtained, became basic ones for substantiating quantitative time dependencies and construction of relevant nomograms for forensic diagnosis of PDC by cholinesterase content in MT. Conclusions: It was proved that the content of cholinesterase in all MT homogenates, which we studied, changed regularly (and nonlinearly), but the initial and final levels of cholinesterase content differed depending upon the type of MT. Besides, the dynamics in changes of the content of cholinesterase within the time period of 3÷13 hours from the moment of death coming differed upon the type of MT too. Advantages of the technique consist in theintegrity of biochemical examination of different types of MT and simplicity in interpretation of findings. The application of the nomogram technique for assessing PDC by cholinesterase content in MT makes it possible to improve the accuracy of diagnosis for terms of the coming of death up to 60 minutes.Item Actual aspects of public health policy formation on the example of Ukraine(Ibn Sina Medical College, 2020) Деміхов, Олексій Ігорович; Демихов, Алексей Игоревич; Demikhov, Oleksii Ihorovych; Дегтярьова, Ія Олександрівна; Дегтярева, Ия Александровна; Dehtiarova, Iia Oleksandrivna; Деміхова, Надія Володимирівна; Демихова, Надежда Владимировна; Demikhova, Nadiia VolodymyrivnaOur publication is devoted to the evolution of the public health system, its role in public health promotion and determination of the basic notions. According to the definition of the World Health Organization, public health is a science and practice of the diseases prevention, increase in life expectancy and health promotion with the help of the organized actions of the society. Yet in practice, public health formed under difficult conditions. In the article we consider the following questions: stages of public health system formation in the world and in Ukraine; analysis of public health system formation in Ukraine: institutional frameworks and strategic priorities and basic operational public health functions in Ukraine. We propose suggestions on legal procedures state improvement in public health in Ukraine in the context of European integration.