Видання зареєстровані авторами шляхом самоархівування
Permanent URI for this communityhttps://devessuir.sumdu.edu.ua/handle/123456789/1
Browse
6 results
Search Results
Item The association analysis between HOTAIR rs920778 single nucleotide polymorphism and ischemic stroke development in Ukrainian population(Center for Molecular Medicine Cologne (CMMC) - University of Cologne, 2019) Моісеєнко, Каріна Ашотівна; Моисеенко, Карина Ашотовна; Moiseienko, Karina Ashotivna; Harbuzova, Yelizaveta Antonivna; Атаман, Олександр Васильович; Атаман, Александр Васильевич; Ataman, Oleksandr Vasylovych; Гарбузова, Єлізавета Антонівна; Гарбузова, Елизавета АнтоновнаItem Association of LYS198ASN polymorphisms of endothelin-1 gene with ischemic atherothrombotic stroke(2016) Олешко, Тетяна Богданівна; Олешко, Татьяна Богдановна; Oleshko, Tetiana Bohdanivna; Обухова, Ольга Анатоліївна; Обухова, Ольга Анатольевна; Obukhova, Olha Anatoliivna; Гарбузова, Вікторія Юріївна; Гарбузова, Виктория Юрьевна; Harbuzova, Viktoriia YuriivnaEndothelin-1 (EDN-1) is the most powerful endogenous vasoconstrictor originally isolated from endothelial cells. It has been implicated as an important factor in the development of vascular dysfunction and cardiovascular disease. Investigations of EDN systems have shown their significance in brain disorders including stroke.Item Association of polymorphic variants of the gene VKORC 1 with ischemic atherothrombotic stroke(Sumy State University, 2016) Harbuzova, Yelizaveta Antonivna; Гарбузова, Єлізавета Антонівна; Гарбузова, Елизавета АнтоновнаAnnually Stroke affects 16 million people and causes the death of nearly 6 million. 88% of all strokes account for ischemic stroke genesis. Disorders in processes of hemostasis and ectopic calcification play the important role in ischemic atherothrombotic stroke development. Today distinguished the group of vitamin K-dependent proteins that includes proteins, which provide hemostasis and proteins that have anticalcifications properties.Item Association TaqI polymorphism of VDR gene in smokers and non-smokers, among patients with ischemic stroke(Sumy State University, 2015) Обухова, Ольга Анатоліївна; Обухова, Ольга Анатольевна; Obukhova, Olha AnatoliivnaThe aim of our study was to analyze the association of TaqI polymorphism of VDR gene in smokers and non-smokers patients with atherothrombotic ischemic stroke.Item Investigation of the MGP promoter and exon 4 polymorphisms in patients with ischemic stroke in the Ukrainian population(Haliç University, Printed in Turkey, 2012) Обухова, Ольга Анатоліївна; Обухова, Ольга Анатольевна; Obukhova, Olha Anatoliivna; Гарбузова, Вікторія Юріївна; Гарбузова, Виктория Юрьевна; Harbuzova, Viktoriia Yuriivna; Атаман, Олександр Васильович; Атаман, Александр Васильевич; Ataman, Oleksandr Vasylovych; Атаман, Юрій Олександрович; Атаман, Юрий Александрович; Ataman, Yurii Oleksandrovych; Matlaj, O.I.Matrix γ-carboxyglutamic acid protein (MGP) is a vitamin K-dependent protein playing a pivotal role in preventing arterial calcification. In the present study, we aimed to investigate the relation between three single nucleotide polymorphisms of MGP gene and ischemic stroke (IS) in the Ukrainian population. 170 IS patients and 124 healthy controls were recruited to the study. MGP SNPs were examined by PCR-RFLP methodology. The distribution of homozygous carriers of the major allelic variant, and heterozygous and homozygous minor allele variants of the T-138C MGP promoter polymorphism (rs1800802) in patients with IS was 61.2%, 31.2% and 7.6%, respectively. The corresponding distributions of the variants in the control group were 59.7%, 35.6%, 4.8%. With regard to the G-7A promoter polymorphism (rs1800801), the respective distributions were 35.9%, 48.8% and 15.3%, compared to 43.5%, 50% and 6.5% in the control group. Finally, the respective distributions according to the Thr83Ala exon 4 polymorphism (rs4236) were 39.4%, 48.8% and 11.8%, compared to 34.7%, 53.2% and 12.1% in the control group. Using logistic regression analysis, it was estimated that A/A genotype (G-7A polymorphism) was significantly (P=0.016) associated with IS (OR=2.943; 95% CI: 1.218–7.109) in the Ukrainian population. A-allele homozygotes of female sex had a risk of IS more than 7 times higher compared with carriers of G/G genotype.Item Candidate genes of ischemic stroke(Сумський державний університет, 2013) Обухова, Ольга Анатоліївна; Обухова, Ольга Анатольевна; Obukhova, Olha Anatoliivna; Sheikh, K.M.Stroke has long been recognized as a major problem for public health. Ischemic stroke (IS) ranks third (after myocardial infarction and cancer) as a cause of death around the world. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/32180