Видання зареєстровані авторами шляхом самоархівування
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Item Morphofunctional reconstructions of the epiphysal-parathyroide axis structural components of rats in the period of readaptation after prolonged exposure to heavy metals(V. Danilevsky institute for endocrine pathology problems of the NAMS of Ukraine, 2020) Гринцова, Наталія Борисівна; Гринцова, Наталия Борисовна; Hryntsova, Nataliia Borysivna; Тимакова, Олена Олександрівна; Тимакова, Елена Александровна; Tymakova, Olena Oleksandrivna; Романюк, Анатолій Миколайович; Романюк, Анатолий Николаевич; Romaniuk, Anatolii MykolaiovychAn important environmental problem is the pollution of the environment with heavy metal salts, which are in various combinations depending on the region and cause adverse effects on public health. The endocrine system together with the immune and nervous system maintains homeostasis in the body. In order to study the morphofunctional rearrangements of the epiphyseal-parathyroid axis structural components in rats during 30 days of readaptation after 90 days of exposure to heavy metal salts (zinc (ZnSO4 · 7H2O) — 5 mg/l, copper (CuSO4 · 5H2O) — 1 mg/l, iron (FeSO4 ) — 10 mg/l, manganese (MnSO4 · 5H2O) — 0.1 mg/l, lead (Pb(NO3 ) 2 ) — 0.1 mg/l and chromium K2Cr2O7) — 0.1 mg/l) an experiment was performed on 24 white sexually mature male rats weighing 250–300 g, aged 7–8 months. The animals of the experimental group consumed ordinary drinking water for 30 days. Morphological, statistical, immunohistochemical and biochemical research methods were used. The 30-day period of readaptation after 90 days of heavy metal salts intake is insufficient to completely restore homeostasis in the epiphyseal-parathyroid system, which is at the stage of chronic stress «subcompensation». Significant morphological changes on the part of the vascular bed of the pineal gland and parathyroid glands (blood stasis, erythrocyte aggregation, sludge phenomenon) were determined, an active glial reaction was formed in the pineal gland, and the structure of the epithelial trabeculae of the glands was disturbed. The levels of parathyroid hormone and calcium in the blood of experimental animals were significantly lower than those of experimental animals. There is a greater vulnerability and faster dynamics of the regenerative processes in the parathyroid glands to the action of salts of heavy metals in comparison with the pineal gland. The development of hypofunction of the parathyroid glands, of course, has a negative effect on the overall calcium metabolism in the body, the development of compensatory and adaptive processes and the course of the general adaptation syndrome in response to the damaging agent.Item Heavy metals effect on the chemical composition variations in rat uterus tissue(The Romanian National Library, 2020) Wireko, A.A.; Сікора, Катерина Олексіївна; Сикора, Екатерина Алексеевна; Sikora, Kateryna Oleksiivna; Линдін, Микола Сергійович; Лындин, Николай Сергеевич; Lyndin, Mykola Serhiiovych; Гирявенко, Наталія Іванівна; Гирявенко, Наталья Ивановна; Hyriavenko, Nataliia IvanivnaHeavy metals (HM) belong to our vital activity's chemical components, which can be essential, potentially dangerous, and dangerous. Their acceptable concentration present in all layers of the biosphere. Simultaneously, excessive environmental pollution causes the disruption of the living organism’s microecology and imbalanced accumulation of HM in the organs. Besides, it is rather difficult to predict the pollutant effect on the body, as the organs and systems may have different sensitivity. One of these organs that can be exposed to the impact of exogenous factors is the uterus. Moreover, the unknown genesis of HM action on the uterus can lead to severe disorders of reproductive health. The aim of our study was to study the peculiarities of the chemical composition accumulation in the rat`s uterus wall under the experimental HM salts mixture influence.Item Ultraviolet impact on rat skin(Springer, 2020) Сулим, Григорій Анатолійович; Сулим, Григорий Анатольевич; Sulym, Hryhorii Anatoliiovych; Линдін, Микола Сергійович; Лындин, Николай Сергеевич; Lyndin, Mykola Serhiiovych; Сікора, Владислав Володимирович; Сикора, Владислав Владимирович; Sikora, Vladyslav Volodymyrovych; Сікора, Катерина Олексіївна; Сикора, Екатерина Алексеевна; Sikora, Kateryna Oleksiivna; Гирявенко, Наталія Іванівна; Гирявенко, Наталья Ивановна; Hyriavenko, Nataliia Ivanivna; Романюк, Анатолій Миколайович; Романюк, Анатолий Николаевич; Romaniuk, Anatolii MykolaiovychThe aim of our study was to establish a >model imitating of UV-B (wavelength peak is 311 nm) therapy for rat’s skin and to find match macroscopical and following histological skin changes including melanocytes spreading and melanin distribution.Item CEACAM1 expression in the normal uterus of rats(Springer, 2020) Сікора, Катерина Олексіївна; Сикора, Екатерина Алексеевна; Sikora, Kateryna Oleksiivna; Линдін, Микола Сергійович; Лындин, Николай Сергеевич; Lyndin, Mykola Serhiiovych; Кравцова, Ольга Іванівна; Кравцова, Ольга Ивановна; Kravtsova, Olha Ivanivna; Сікора, Владислав Володимирович; Сикора, Владислав Владимирович; Sikora, Vladyslav Volodymyrovych; Романюк, Анатолій Миколайович; Романюк, Анатолий Николаевич; Romaniuk, Anatolii Mykolaiovych; Singer, B.B.The carcinoembryonic antigen-related adhesion molecules (CEACAM) play a significant role in numerous physiological processes, such as cell-cell and cell-ECMadhesion, angiogenesis, proliferation, etc. The objective is characterization of the CEACAM1 expression pattern in normal tissues of rat uterus.Item Microbiological characteristic of the experimental use of autobiotic on the model of antibiotic – induced dysbiosis in old rats(Nemoros s.r.o., 2019) Івахнюк, Тетяна Василівна; Ивахнюк, Татьяна Васильевна; Ivakhniuk, Tetiana Vasylivna; Івахнюк, Юрій Петрович; Ивахнюк, Юрий Петрович; Ivakhniuk, Yurii Petrovych; Dovhan, R.; Makarenko, O.M.У статті наведені та обговорені результати експериментально модульованого дисбіозу кишечнику у щурів, наведені дані біологічних властивостей представників мікрофлори кишечнику в аспекті корекції даного стану та розглянуті питання перспективи використання аутобіотичних препаратів.Item Effect of heavy metals on the readaptive processes in the urinary bladder(Bangladesh Academy of Sciences, 2019) Романюк, Анатолій Миколайович; Романюк, Анатолий Николаевич; Romaniuk, Anatolii Mykolaiovych; Сікора, Владислав Володимирович; Сикора, Владислав Владимирович; Sikora, Vladyslav Volodymyrovych; Линдіна, Юлія Миколаївна; Лындина, Юлия Николаевна; Lyndina, Yuliia Mykolaivna; Линдін, Микола Сергійович; Лындин, Николай Сергеевич; Lyndin, Mykola Serhiiovych; Гирявенко, Наталія Іванівна; Гирявенко, Наталья Ивановна; Hyriavenko, Nataliia Ivanivna; Карпенко, Людмила Іванівна; Карпенко, Людмила Ивановна; Karpenko, Liudmyla Ivanivna; Піддубний, Артем Михайлович; Поддубный, Артем Михайлович; Piddubnyi, Artem Mykhailovych; Miroshnichenko, M.Introduction: Heavy metals (HM) are dangerous elements due to their toxicity and prevalence play an important role in the environmental pollution and hazards to health risk. Impact of HM at high concentrations may lead to the failures of urinary bladder (UB) structure and functions. The aim of our study was to determine the readaptive changes in the UB of the rats and effectiveness of vitamin E using after the long-term intake of the HMS mixtures.Item Morphological changes in collagen fibers of urinary bladder caused by influence of heavy metal salts(Sumy State University, 2017) Сікора, Володимир Віталійович; Сикора, Владимир Витальевич; Sikora, Volodymyr Vitaliiovych; Романюк, Анатолій Миколайович; Романюк, Анатолий Николаевич; Romaniuk, Anatolii Mykolaiovych; Линдіна, Юлія Миколаївна; Лындина, Юлия Николаевна; Lyndina, Yuliia Mykolaivna; Карпенко, Людмила Іванівна; Карпенко, Людмила Ивановна; Karpenko, Liudmyla Ivanivna; Jimoh, M.Introduction. Today the environmental pollution with heavy metal salts (HMS) is an important issue, because of their toxic effects and prevalence in different layers of the biosphere. Once getting in the body, they circulate with blood and partly accumulated in the organs causing harmful effects on tissues and cells. Urinary bladder(UB) refers to bodies that are subject to double impact of heavy metals. Thus, urine together with its components (including HMS)accumulate and definite time contact with mucous membranes of UB and also the pollutants get into the organhematogenously.Item Modeling cryonecrosis of the myocardium in rats(Sumy State University, 2017) Fesenko, I.V.; Sheyan, D.M.Relevance. Every year in our country there are nearly 50 thousand new cases myocardial infarction. Myocardial infarction (MI) is one of the forms of myocardial necrosis caused by a violation of inflow of blood through the affected artery. Improving ways to prevent and treat THEM can be based on new experimental models.Item Structural changes of rat's heart under the influence of hypoosmolar hyperhydration(Sumy State University, 2017) Bumeister, L.V.Actuality: A cardiovascular diseases are the leading cause of death and disability population in the most countries of the world. Disorders of water-salt homeostasis are very common problems encountered in clinical medicine. Disorders of water and electrolyte balance accompany a significant number of diseases of the endocrine, urinary, cardiovascular systems and have a place in daily clinical practice, causing violations of the structure and function of organs.Item Morphological changes of myocardium in conditions of simulated osteoporosis(Sumy State University, 2017) Yusupova, A.F.Relevance. Various forms and stages of osteoporosis are characterized by changes in the concentration of Calcium in blood. Calcium is one of the foundational elements which influences myocardial contractile function. Aim. The aim of the study is to investigate pathological changes of myocardium in conditions of modelled osteoporosis.