Видання зареєстровані авторами шляхом самоархівування
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Item Ultramorphometric characteristics of acini and microvasculature of the pancreas in the presence of moderate dehydration(Fundacja Lekarzy Polskich-Pro-Medica, 2022) Ковчун, Віктор Юрійович; Kovchun, Viktor Yuriiovych; Сміянов, Владислав Анатолійович; Smiianov, Vladyslav Anatoliiovych; Ковчун, Анна Володимирівна; Kovchun, Anna Volodymyrivna; Качковська, Владислава Володимирівна; Kachkovska, Vladyslava Volodymyrivna; Сікора, Віталій Зіновійович; Sikora, Vitalii ZinoviiovychThe aim: The objective of our study was to evaluate the features of ultramorphometric characteristics of exocrine parenchyma and microvasculature of the pancreas in the presence of moderate dehydration by means of an experiment in laboratory rats. Materials and methods: The experiment involved 20 mature white male rats divided into 2 groups: control and experimental (10 rats each). In the experimental group, moderate dehydration was simulated, i.e. the animals were deprived of water for 7 days, while the control rats were provided with a normal water supply during the study. Pancreatic parenchyma samples were fixed in phosphate-buffered glutaraldehyde solution and post-fixed in osmium tetroxide solution, dehydrated and embedded in a mixture of epoxy resins. Ultrastructural analysis was performed using JEOL JEM-1230 transmission electron microscope (Japan). Results: Pancreatic electron microscopy in the presence of moderate dehydration demonstrated statistically significant changes in exocrinocytes area and exocrinocyte nucleus area which increased by 8.02% (p = 0.028) and 40.28% (p < 0.001), respectively. Among the vessels of microcirculation, the largest changes occurred in the capillaries: their lumen narrowed by 22.34% (p = 0.002) as compared with the control group. The cytoplasm of endothelial cells contained a large number of vacuoles and micropinocytotic vesicles. Conclusions: Among the organelles of exocrinocytes, mitochondria appeared the most vulnerable to the effects of dehydration. They demonstrated polymorphic changes: a part of the mitochondria was hypotrophic and had partially reduced cristae, and another part was hypertrophic.Item Ultrastructural changes of the thymus in the conditions of general dehydration(Sumy State University, 2017) Udovychenko, S.Introduction. The thymus is extremely sensitive to ekopathogenic factors and quite fast undergoes involution which negatively impacts the immunity. Acute water shortage in extreme natural conditions, various pathological agents lead to structural changes of several organs and systems, so it was our aim to reveal the features of ultrastructural changes in the thymus dehydration.Item Morphological changes of stomach influenced by general dehydration(Sumy State University, 2016) Hula, V.I.It is well known that the digestive system is very sensitive to a large number of different negative factors. In particular, frequent lesions in the stomach is exposed as its organ and the main reservoir of mechanical and chemical processing of food. It is necessary to say that the effect of dehydration of the stomach has not been adequately studied. The significant amount of water and electrolytes is deposited in the gastrointestinal tract and is involved in the exchange, circulating between blood and content of the digestive tract. That is why the aim of this thesis was to discover structural and morphological changes in stomach due to the total dehydration.Item Ultrastructural changes of rat’s erythrocytes in the condition of general dehydration(Sumy State University, 2015) Bumeister, L.V.One of the modern areas of researchers of modern morphology is detection of morphological changes in organs and tissues of the human body, which are formed by influence of environmental factors, among which we can select and dehydration. The influence of dehydration on the body has a general nature, but the organs and tissues react to the dehydration differently.