Видання зареєстровані авторами шляхом самоархівування
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Item A comprehensive approach to hypothyroidism therapy: lifestyle, pharmacology, and metabolic health(Sumy State University, 2025) Cherkashyna, A.; Мальована, Нiна Володимирiвна; Malovana, Nina VolodymyrivnaA comprehensive approach to hypothyroidism therapy that combines adequate pharmacological correction, regular physical activity, and balanced nutrition is a key factor in improving patients’ quality of life and preventing metabolic complications [1, p.170]. Hypothyroidism, one of the most prevalent endocrine disorders, is characterized by insufficient production of thyroid hormones, resulting in a reduced basal metabolic rate, energy imbalance, dyslipidemia, impaired glucose tolerance, and deterioration of overall health. Clinical symptoms often include persistent fatigue, cold intolerance, weight gain, depression, memory impairment, and decreased physical performance, which may partially persist despite standard levothyroxine replacement therapy [2, p.121]. This persistence of symptoms indicates the need for an expanded, multimodal therapeutic strategy. Non-pharmacological interventions – including lifestyle modification, physical activity, and targeted nutritional therapy – are essential components that contribute to the restoration of metabolic balance and functional homeostasis [3, p.2].Item Efficiency of the intravenous laser therapy in metabolic disorders correction(ALUNA, 2017) Мелеховець, Оксана Костянтинівна; Мелеховец, Оксана Константиновна; Melekhovets, Oksana Kostiantynivna; Сміянов, Євген Владиславович; Смиянов, Евгений Владиславович; Smiianov, Yevhen Vladyslavovych; Rudenko, L.; Жалдак, Дар`я Олександрівна; Жалдак, Дарья Александровна; Zhaldak, Dar`ia Oleksandrivna; Мелеховець, Юрій Володимирович; Мелеховец, Юрий Владимирович; Melekhovets, Yurii Volodymyrovych; Kovalenko, E.; Harust, J.; Shvydun, E.Despite the wide range of medicines which are used for the treatment of any disease, today increasing attention is paid to physiotherapy methods, namely the method of the intravenous laser therapy (ILT) which has been successfully used for the last 30 years in almost all areas of medicine. To estimate the effectiveness of ILT in the treatment of patients with hypothyroidism combined with nonalcoholic fatty liver disease (NAFLD) 180 people with dyslipidemia were examined. The 1st group included 60 patients who didn’t have any complaints but had dyslipidemia. The 2nd group included 60 patients with NAFLD, the 3rd group included 60 patients with hypothyroidism combined with NAFLD. Based on the genetic research of polymorphic variants of the CYP7A1 gene, patients were divided into the following subgroups: 1 AA – 52 patients, 1 CC – 8 patients; 2 AA – 50 patients, 2 CC – 10 patients; 3 AA – 48 patients, 3 CC – 12 patients. Treatment was provided with Omega-3 Acid Ethyl Esters and ILT with laser wavelength λ=635 nm and laser power equals to 1,5 mW. The most pronounced effect was achieved in 2 CC and 3 CC groups due to reducing of TC, LDL, TG and the Atherogenic Index. Patients of 2 AA and 3 AA groups had statistically significant dynamics of HDL increasing. The dynamics of normalization of cytolysis syndrome indices didn’t have genetically determined differences and prevailed in the 2nd group compared to the 3rd group in which the presence of hormonal imbalance delayed the activation of reparative mechanisms of damaged liver cells.Item Lipid abnormalities in type 1 diabetes accompanied by hypothyroidism(Sumy State University, 2015) Kwaku, OwusuPatients with one organ-specific autoimmune disease are at risk of developing other autoimmune disorders. There is a high incidence of autoimmune thyroid disorders among patients with type 1 diabetes mellitus (DM).