Факультет електроніки та інформаційних технологій (ЕлІТ)
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Item The Study of the Alginate / Hydroxyapatite Composites Structural Properties(Sumy State University, 2014) Суходуб, Леонід Федорович; Суходуб, Леонид Федорович; Sukhodub, Leonid Fedorovych; Kuznetsov, V.N.; Sukhodub, L.B.This paper describes the synthesis of sodium alginate (Alg) / hydroxyapatite (HA) composites and the influence of the presence of Alg on HA crystallization. Such composites become rather widespread in recent years, and are used in medicine generally for the controlled drug delivery [1‑3]. In one’s case, Alg is used as the functional and cost-effective replacement of the collagen for the creation of implants similar to the natural bone [4]. It was shown that the presence of Alg and the increase of its concentration leads to the decrease of the HA crystallinity thus providing an ability to control its levels in the resulting product. The FTIR studies confirm the incorporation of Alg in the Alg / HA composite structure.Item Alginate-hydroxyapatite Beads for Medical Application(Sumy State University, 2014) Stanislavov, A.; Sukhodub, L.B.; Yanovska, A.A.; Суходуб, Леонід Федорович; Суходуб, Леонид Федорович; Sukhodub, Leonid Fedorovych; Kuznetzov, V.N.The paper describes the synthesis and characterization of alginate-hydroxyapatite (Alg/HA) beads that potentially can be used for drug release due to the adsorptive properties of HA and transmission ability of the soluble compounds through the alginate membrane. Calcium Alg/HA beads were manufactured by dropping of the Alg/HA suspension into CaCl2 solution. Morphology and phase composition of obtained Alg/HA beads were investigated. It was shown that alginate macromolecules influence the hydroxyapatite size and morphology. Obtained HA with crystal size 15-30 nm inside alginate beads correspond a bioapatite size therefore are interesting for the tissue engineering. The main features of alginate-controlled crystallization are discussed in order to understand some aspects in composite material design. Insertion of HA into the alginate microcapsules allows use such materials for production of drug release microspheres.Item The Influence of Ultrasound and Ultraviolet Irradiation on the Nanocomposite Calcium Phosphate-Polymeric Gel(Sumy State University, 2013) Musskaya, O.N.; Kulak, A.I.; Krutsko, V.K.; Ulasevich, S.A.; Lesnikovich, L.A.; Суходуб, Леонід Федорович; Суходуб, Леонид Федорович; Sukhodub, Leonid FedorovychAn influence of high-intensive ultrasound and ultraviolet (UV) irradiation on the nanocomposite calcium phosphate-polymeric gels has been investigated. The action of UV light leads to a significant increase in shear stress and viscosity of hydroxyapatite (HA) / polyvinyl alcohol (PVA) gel while HA / sodium carboxymethyl cellulose (Na-CMC) gel is insensitive to the UV action. Ultrasonic treatment of HA / PVA gel plays an important role only at small shear rates. UV treatment of HA / Na-CMC gel has no effect on its structure and can be used for low temperature UV sterilization. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/35469Item Biphasic Calcium Phosphate Composite for Biomedical Applications(Sumy State University, 2013) Sukhodub, L.B.; Kulak, A.I.; Іншина, Наталія Миколаївна; Иншина, Наталия Николаевна; Inshyna, Nataliia Mykolaivna; Kuznetsov, V.N.; Stanislavov, A.S.; Суходуб, Леонід Федорович; Суходуб, Леонид Федорович; Sukhodub, Leonid FedorovychThe paper describes the preparation of the biphasic (hydroxyapatite (HA) and tricalcium phosphate (TCP)) nanostructured calcium phosphate composite. The product was chemically synthesized from the solution which contained calcium acetate Са(СН3СОО)2 (0,167 mМ), sodium dihydrogen phosphate NaH2PO4 (0,1 mМ), sodium hydrocarbonate NaHCO3 (0,02 mM). The calcium phosphate composite was formed at pH=11 with and without the addition of carbonate ions. The samples were analyzed using X-Ray diffraction after the heat treatment at 900C for 1 h. The derived material contained HA and TCP phases with their contents change depending on the concentration of the carbonate ions in the solution. The mean crystallite size of the HA phase in (121) plane is 12 – 14 nm. Further studies will be directed to the using of the derived composite for the biomedical applications. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/35448Item Functional Coatings Based on Hydroxyapatite and Polymers Formed on Ti-6Al-4V Substrates(Sumy State University, 2013) Yanovska, G.O.; Kuznetsov, V.M.; Stanislavov, O.S.; Суходуб, Леонід Федорович; Суходуб, Леонид Федорович; Sukhodub, Leonid FedorovychThe paper describes perspective technology for deposition of inorganic-organic coatings used for biomedical application. Synthetic hydroxyapatite was used as inorganic compound, due to the similarity of the main component to bone tissue. As organic components we used chitosan and alginate – natural biopolymers, which widely used for bioactive and biocompatible composites formation. Thermal substrate method used for coatings deposition based on principle of decreasing solubility of hydroxyapatite with increasing of substrate temperature and allow to deposit coatings at substrate temperatures below 100 °C. Porous composite hydroxyapatite-chitosan and hydroxyapatite-alginate coatings were obtained on Ti-6Al-4V substrates. Morphology, phase composition and adhesion to the substrate surface were investigated. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/35297