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Title | Application of plasmonic nanomaterials in nanomedicine |
Authors |
Letfullin, R.
Murphy, B. |
ORCID | |
Keywords | |
Type | Conference Papers |
Date of Issue | 2011 |
URI | http://essuir.sumdu.edu.ua/handle/123456789/20588 |
Publisher | Видавництво СумДУ |
License | |
Citation | Letfullin, R. Application of plasmonic nanomaterials in nanomedicine [Текст] / R. Letfullin, B. Murphy // Nanomaterials: applications & properties. Proceedings : 1-st International conference, Alushta, Crimea, 27-30 Semptember 2011 / Edited by: A. Pogrebnjak, T. Lyutyy, S. Protsenko. - Sumy : Sumy State University, 2011. - V.1, P.І. - C. 92-97. |
Abstract |
Plasmonic nanoparticles are being researched as a noninvasive tool for ultrasensitive
diagnostic, spectroscopic and, recently, therapeutic technologies. With particular
antibody coatings on nanoparticles, they attach to the abnormal cells of interest (cancer
or otherwise). Once attached, nanoparticles can be activated/heated with UV/visible/IR,
RF or X-ray pulses, damaging the surrounding area of the abnormal cell to the point of
death. Here, we describe an integrated approach to improved plasmonic therapy composed
of nanomaterial optimization and the development of a theory for selective radiation
nanophotothermolysis of abnormal biological cells with gold nanoparticles and selfassembled
nanoclusters. The theory takes into account radiation-induced linear and
nonlinear synergistic effects in biological cells containing nanostructures, with focus on
optical, thermal, bubble formation and nanoparticle explosion phenomena. On the basis
of the developed models, we discuss new ideas and new dynamic modes for cancer
treatment by radiation activated nanoheaters, which involve nanocluster aggregation in
living cells, microbubbles overlapping around laser-heated intracellular nanoparticles/
clusters, and laser thermal explosion mode of single nanoparticles (‘nanobombs’)
delivered to the cells.
When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/20588 |
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