Видання зареєстровані авторами шляхом самоархівування
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Item Epidemilogy of ENT disorders in adult population of agricultural region(Aluna Publishing House, 2021) Сміянов, Владислав Анатолійович; Smiianov, Vladyslav Anatoliiovych; Ємець, Тетяна Василівна; Yemets, Tetiana Vasylivna; Сміянов, Євген Владиславович; Smiianov, Yevhen Vladyslavovych; Горностаєва, Поліна Олександрівна; Hornostaieva, Polina OleksandrivnaThe aim of the work was to study and analyze Sumy region population morbidity dynamics taking into account current stage of medical reform. Sumy region here is represented as one of the main agricultural regions of Ukraine. The prevalence of ENT disorders (otolaryngologic diseases) was studied.Item Аnalysis of the blood hypercoagulation risk in patients with ischemic atherothrombotic stroke depending of the vdr gene polymorphisms(Aluna publishing, 2023) Обухова, Ольга Анатоліївна; Obukhova, Olha Anatoliivna; Гарбузова, Вікторія Юріївна; Harbuzova, Viktoriia Yuriivna; Завадська, Марина Миколаївна; Zavadska, Maryna Mykolaivna; Левченко, Зоя Михайлівна; Levchenko, Zoia Mykhailivna; Бєсєдіна, Антоніна Анатоліївна; Biesiedina, Antonina Anatoliivna; Гарбузова, Єлізавета Антонівна; Harbuzova, Yelizaveta Antonivna; Сміянова, Юлія Олегівна; Smiianova, Yuliia Olehivna; Сміянов, Владислав Анатолійович; Smiianov, Vladyslav AnatoliiovychМета: дослідження ризику гіперкоагуляції крові у хворих на ішемічний атеротромботичний інсульт залежно від поліморфізму гена VDR. Матеріали і методи. Для генотипування використано кров 170 хворих на ішемічний атеротромботичний інсульт (ІАТІ) та 124 здорових осіб (група контролю). Чотири поліморфізми (FokI, BsmI, ApaI, TaqI) гена VDR досліджували методом ПЛР-ПДРФ. Статистичний аналіз проводили за допомогою програми SPSS-17.0. Результати. Серед хворих на ІАТС, які є носіями генотипу f/f, зареєстровано FokI поліморфізм гена VDR за високим тромбіновим часом та зниженням швидкості спонтанного фібринолізу. В осіб з генотипом B/B, гомозиготним за поліморфним варіантом, BsmI мав значно нижчі середні значення протромбінового та тромбінового часу та збільшував швидкість спонтанного фібринолізу. Було виявлено, що гомозиготи за поліморфізмом А-алелі ApaI мають у 2,7 рази вищий ризик розвитку гіперкоагуляції крові, ніж гомозиготи за а-алелем. Висновки. Біохімічні ознаки синдрому гіперкоагуляції у хворих на ІАТС, які є носіями генотипу f/f поліморфного варіанту FokI та серед гомозигот В/В поліморфного варіанту BsmI та гомозигот за А-алелем поліморфізму AрaI VDR. були зареєстровані гени.Item The microbiological structure of otomycosis: sensitivity profile of agents to antifungal drugs(ALUNA Publishing House, 2023) Сміянов, Владислав Анатолійович; Smiianov, Vladyslav Anatoliiovych; Івахнюк, Тетяна Василівна; Ivakhniuk, Tetiana Vasylivna; Плахтієнко, Інна Олександрівна; Plakhtiienko, Inna Oleksandrivna; Сміянов, Євген Владиславович; Smiianov, Yevhen Vladyslavovych; Горностаєва, Поліна Олександрівна; Hornostaieva, Polina OleksandrivnaThe aim of the work was to study the species composition of microorganisms isolated from patients with otomycosis, and to control the sensitivity of isolated microorganisms to the most commonly used antifungal drugs.Item Effectiveness of the magnesium application in obstetrical practice(ALUNA Publishing House, 2023) Сміянов, Владислав Анатолійович; Smiianov, Vladyslav Anatoliiovych; Markin, L.B.; Fartushok, T.V.; Slavitych, S.R.The aim of the work was to conduct the evaluation of the effectiveness and safety of the use of magnesium in pregnant women.Item Medical and social analysis of patients who died of SARS-COV-2 in the specialized infectious department of the city of Sumy during the first wave of the epidemic(ALUNA Publishing House, 2023) Сміянов, Владислав Анатолійович; Smiianov, Vladyslav Anatoliiovych; Півень, Світлана Миколаївна; Piven, Svitlana Mykolaivna; Дрига, Наталія Олександрівна; Dryha, Nataliia Oleksandrivna; Сміянова, Ольга Іванівна; Smiianova, Olha Ivanivna; Плахтієнко, Інна Олександрівна; Plakhtiienko, Inna Oleksandrivna; Кучма, Наталія Григорівна; Kuchma, Nataliia Hryhorivna; Жук, Катерина Ігорівна; Zhuk, Kateryna IhorivnaThe aim of the article is to analyze demographic indicators, clinical symptoms, concomitant pathology, and the course of acute respiratory viral infection (ARVI) caused by SARS-CoV-2 in patients with a fatal outcome of the disease.Item Ultramorphometric characteristics of acini and microvasculature of the pancreas in the presence of moderate dehydration(Fundacja Lekarzy Polskich-Pro-Medica, 2022) Ковчун, Віктор Юрійович; Kovchun, Viktor Yuriiovych; Сміянов, Владислав Анатолійович; Smiianov, Vladyslav Anatoliiovych; Ковчун, Анна Володимирівна; Kovchun, Anna Volodymyrivna; Качковська, Владислава Володимирівна; Kachkovska, Vladyslava Volodymyrivna; Сікора, Віталій Зіновійович; Sikora, Vitalii ZinoviiovychThe aim: The objective of our study was to evaluate the features of ultramorphometric characteristics of exocrine parenchyma and microvasculature of the pancreas in the presence of moderate dehydration by means of an experiment in laboratory rats. Materials and methods: The experiment involved 20 mature white male rats divided into 2 groups: control and experimental (10 rats each). In the experimental group, moderate dehydration was simulated, i.e. the animals were deprived of water for 7 days, while the control rats were provided with a normal water supply during the study. Pancreatic parenchyma samples were fixed in phosphate-buffered glutaraldehyde solution and post-fixed in osmium tetroxide solution, dehydrated and embedded in a mixture of epoxy resins. Ultrastructural analysis was performed using JEOL JEM-1230 transmission electron microscope (Japan). Results: Pancreatic electron microscopy in the presence of moderate dehydration demonstrated statistically significant changes in exocrinocytes area and exocrinocyte nucleus area which increased by 8.02% (p = 0.028) and 40.28% (p < 0.001), respectively. Among the vessels of microcirculation, the largest changes occurred in the capillaries: their lumen narrowed by 22.34% (p = 0.002) as compared with the control group. The cytoplasm of endothelial cells contained a large number of vacuoles and micropinocytotic vesicles. Conclusions: Among the organelles of exocrinocytes, mitochondria appeared the most vulnerable to the effects of dehydration. They demonstrated polymorphic changes: a part of the mitochondria was hypotrophic and had partially reduced cristae, and another part was hypertrophic.Item The role of leptinresistance in the pathogenesis of obesity in pregnant women(Aluna Publishing, 2022) Сміянов, Владислав Анатолійович; Смиянов, Владислав Анатольевич; Smiianov, Vladyslav Anatoliiovych; Fartushok, T.V.; Rudenko, L.A.; Fartushok, N.V.The aim: To investigate the relationship between leptin resistance, lipid and carbohydrate metabolism, blood pressure in obese pregnant women. Materials and methods: Under observation were 65 women (main group) with obesity (I degree -27 women, II degree - 24 women, III degree - 14 women) in the II trimester of pregnancy, who were hospitalized in the Department of Pathology of Pregnancy KNP «Maternity Clinical house №1 ”in Lviv during 2017-2020 on preeclampsia of varying severity, which were sent for inpatient treatment by women’s clinics. The control group consisted of 30 healthy pregnant women without obesity. Results: Serum leptin in obese women was directly correlated with BMI (r = 0.66, p<0.001), body weight (r = 0.29, p<0.05), total cholesterol (cholesterol) (r = 0, 37,p<0,009), low density lipoproteins (LDL cholesterol) (r = 0.33, p<0.05) and inversely with high density particles (HDL cholesterol) (r = -0.37, p<0.02 ). Studies of carbohydratemetabolism indicate the following correlation coefficients of BMI with glucose level r = 0.351; p<0,001, BMI with the level of C-peptide r = 0,450; p<0,001, BMI with HOMA index r = 0,1504; p = 0.036. Inverse correlations of C-peptide were detected with the level of P (r = -0.169; p = 0.025). Conclusions: The discovery of the relationship between leptin resistance, lipid and carbohydrate metabolism, blood pressure indicates the possibility of using signs of leptin resistance to prevent complications during pregnancy in the second trimester.Item Determination of the Hazard of Medical Waste in the Convention of the Covid-19 Pandemic(Aluna Publishing, 2022) Brezytska, D.M.; Hushchuk, I.V.; Сміянов, Владислав Анатолійович; Смиянов, Владислав Анатольевич; Smiianov, Vladyslav Anatoliiovych; Vivsiannyk, O.M.; Safonov, R.V.; Khoronzhevska, I.S.Aim: To determine the infectious danger of medical waste from patients with COVID-19, by examining them for the presence of coronavirus SARS-CoV-2. Materials and Methods: Regulatory – legal acts, foreign editions, results of the laboratory researches that we received served as materials for carrying out research. While researching such methods were used: descriptive, bibliographic, analytical, epidemiological, laboratory diagnostics, statistical. Results: The study confirmed the presence of RNA of the coronavirus SARS-CoV-2 in 5 selected samples from protective masks of patients with COVID-19 (8.9%) by polymerase chain reaction (PCR). SARS-CoV-2 coronavirus was not detected in samples taken from medical masks. Separate studies of wastewater from the infectious disease hospital of Ostroh General Hospital and from the city sewer network for the presence of coronavirus SARS-Cov-2 were conducted. SARS-CoV-2 coronavirus was not detected in the selected samples by PCR. Conclusions: The results of the study confirm the infectious potential of medical waste, mostly wrong treatment.Item Improving the Quality of Medical Care and Prevention in Patients with Type 2 Diabetes on the Basis of Remote Medical Service(Aluna Publishing, 2022) Сміянов, Владислав Анатолійович; Смиянов, Владислав Анатольевич; Smiianov, Vladyslav Anatoliiovych; Дрига, Наталія Олександрівна; Дрыга, Наталия Александровна; Dryha, Nataliia Oleksandrivna; Rudenko, L.A.Aim: To analyze the effectiveness of implementation of remote medical service, involving patients with type 2 diabetes mellitus in dynamic monitoring of their health and treatment, designed to optimize the quality of medical care and prevention at the primary health care level. Materials and Methods: The study included adults aged 18 to 70 years, residents of Sumy who suffer from diabetes. They took part in a medical and sociological survey before introduction of the ICS and gave consent for processing and using of their personal data. A total of 96 patients were involved. We conducted a survey form of the study, using a closed questionnaire for medical and sociological research, conducted during December 2019. The study included such methods as systematic approach, bibliosemantic, comparative and statistical analyses, logical generalization. Results: During the following medical and sociological survey, 96 questionnaires from Sumy residents aged 18 to 69 years, 58 women (60,42±3,53%) and 38 men (39,58±3,53%)) were studied. Analysis of re-monitoring results showed that during the period of implementation of the ICS at the level of primary health care, the indicators of MCQ and health status of respondents have improved. The proportion of patients, who regularly control the level of blood pressure, increased by 32.29%, and those, who control the level of blood glucose – by 31.24%. The incidence of hypoglycemia and/or ketoacidosis states has decreased by 4.17%. During the survey, the part of respondents with targeted blood pressure level increased by 25.00% and the number of respondents with satisfactory level of diabetes compensation increased by 29.18%. The survey showed that more respondents (12.5%) began to regularly take prescribed medications; the number of those, who began to follow diet and dietary regimen has increased by 28.12%; 5.19% of respondents abandoned bad habits (smoking). The number of respondents who have a body mass index ≥ 30.0 has decreased by 4.69%. Conclusions: The introduction of information and communication system (ICS) with feedback between patient and provider of medical services at the primary health care institution level has shown a positive impact on involvement of patients in dynamic monitoring of their health, responsible attitude to prevention of chronic non-communicable diseases` development and their complications, awareness of the impact of modified risk factors on their health.Item The Impact of Nutritional Quality on the Students’ Health(Aluna publishing, 2021) Griban, G.P.; Сміянов, Владислав Анатолійович; Смиянов, Владислав Анатольевич; Smiianov, Vladyslav Anatoliiovych; Lyakhova, N.A.; Tkachenko, P.P.; Harlinska, A.M.; Dovgan, N.Yu.; Karpiuk, R.P.; Brytan, Y.A.Aim: To study the nutritional quality and its impact on the health of the students of higher education institutions. Material and methods: 647 students were interviewed. A questionnaire, which contains 17 questions and is aimed at studying the quality of students’ nutrition, was created by authors. Experimental (EG, n = 60) and control (CG, n = 60) groups were formed. The EG included the students whose diet was rational while studying, the CG included the students whose diet was irrational. The level of students’ health was examined at the end of studying according to the methodology of professor G.L. Apanasenko. Results: It was found that only 30.6% of students ate 3-4 times a day, 14.4% – twice a day, 49.8% did not follow any dietary regimen, and 7.9% of students would not eat breakfast at al 43.7% of male students and 53.3% of female students did not follow a dietary regimen at all. A comparative analysis of the physical health of students of EG and CG showed that among both male and female students, the students whose diet was rational had significantly better (p<0.001) level of health. Conclusions: It was determined that the majority of students had low nutritional quality while studying: nutrition was irrational, incomplete, and not varied. This does not contribute to a healthy lifestyle of modern students and can negatively affect the efficiency of their future professional activities.