Видання зареєстровані авторами шляхом самоархівування
Permanent URI for this communityhttps://devessuir.sumdu.edu.ua/handle/123456789/1
Browse
7 results
Search Results
Item PWE-50 Dependence of BMI on c677t and a1298c polymorphisms of methyl entrahydrafolatreductase-gene in patients with non-alcoholic-fatty-liver-disease(BMJ Publishing Group Ltd, 2021) Abdul-Rahman, T.; Wireko, A.A.; Кучма, Наталія Григорівна; Kuchma, Nataliia Hryhorivna; Obinna, S.A.Introduction Non-alcoholic fatty liver disease (NAFLD) occurs in almost 50% of the adult population and is the cause of liver dysfunction in developed countries. The widespread use of overweight makes the problem of NAFLD relevant among both adults and children. The vast majority of patients with NAFLD are overweight and obese, which increases the risk of developing atherosclerosis, hypertension and type 2 diabetes and accelerates the progression of pathological changes in the liver. Genes associated with the onset and progression of liver disease and obesity are widely studied today. There is evidence that the methylenetetrahydrofolate reductase (MTHFR) gene affects the development and progression of NAFLD and hyperhomocysteinemia, associated with allelic polymorphism of this gene affects the development of pathological changes in the liver and in the body as a whole. Aim The aim of our study was to investigate the dependence of BMI on C677T and A1298C polymorphisms of the MTGFR gene in patients with NAFLD. Method We monitored 110 patients with NAFLD. The diagnosis of NAFLD was made on the basis of laboratory and instrumental methods of examination. The calculation of BMI was performed according to the formula Kettle - weight (kg)/height (m)2. Determination of allelic polymorphism was performed by PCR with detection of results by hybridization-fluorescence method in real time. Results As a result of our studies, we found that carriers of genotypes C677C, C677T and T677T of the MTGFR gene had BMI values of 34.7 ± 3.6, 37.9 ± 3.8 and 39.7 ± 3.2 kg/m2. We found that patients carrying the T-allele (C/T and T/T genotypes) had significantly higher BMIs compared to homozygotes for the main C-allele (C/C genotype). Studying the frequency of genotypes by A1298C polymorphism of the MTGFR gene depending on BMI, it was found that carriers of genotypes A1298A, A1298C and C1298C had BMI values of 37.1 ± 4.1, 36.6 ± 4.2 and 36.9 ± 3.8 kg/m2 in accordance. We did not find a significant difference in the frequency distribution of genotypes by A1298C polymorphism depending on BMI. Conclusions BMIs are favorably associated with the frequency of genotypes by the C677T polymorphism of the MTGFR gene and do not have such an association with the frequency of genotypes by the A1298C polymorphism of the MTGFR gene.Item Medical and social analysis of patients who died of SARS-COV-2 in the specialized infectious department of the city of Sumy during the first wave of the epidemic(ALUNA Publishing House, 2023) Сміянов, Владислав Анатолійович; Smiianov, Vladyslav Anatoliiovych; Півень, Світлана Миколаївна; Piven, Svitlana Mykolaivna; Дрига, Наталія Олександрівна; Dryha, Nataliia Oleksandrivna; Сміянова, Ольга Іванівна; Smiianova, Olha Ivanivna; Плахтієнко, Інна Олександрівна; Plakhtiienko, Inna Oleksandrivna; Кучма, Наталія Григорівна; Kuchma, Nataliia Hryhorivna; Жук, Катерина Ігорівна; Zhuk, Kateryna IhorivnaThe aim of the article is to analyze demographic indicators, clinical symptoms, concomitant pathology, and the course of acute respiratory viral infection (ARVI) caused by SARS-CoV-2 in patients with a fatal outcome of the disease.Item Interactive Cases of Bioethics and Public Health: by the Examples of Counteraction to Xenophobia, Discrimination and Inequality(Aluna Publishing, 2022) Губенко, Ганна Володимирівна; Губенко, Анна Владимировна; Hubenko, Hanna Volodymyrivna; Boichenko, N.M.; Півень, Світлана Миколаївна; Пивень, Светлана Николаевна; Piven, Svitlana Mykolaivna; Кучма, Наталія Григорівна; Кучма, Наталья Григорьевна; Kuchma, Nataliia Hryhorivna; Бондаркова, Анна Миколаївна; Бондаркова, Анна Николаевна; Bondarkova, Anna MykolaivnaAim: This article examines how bioethicists can make a significant contribution to mediation, public discourse, research, educating, learning, policy-making and academic impact in response to troubling and persistent models of xenophobia, racism and ‘pretentious’ prejudice. In order to make a meaningful contribution to these issues, bioethicists need training, awareness that they can play an important educational role in cooperation with other specialists and social spheres. Materials and Methods: An understanding of these issues from the perspective of bioethics is important in terms of the methodological approach that is used in its explanations. For example, in education, public health, etc. In the course of the research the bibliographic, bibliosemantic method, the method of system analysis. Conclusions: The main mechanism for combating xenophobia is the development of personal and social tolerance. Tolerance does not require an obligatory love to «our own»’ and to «others», but offers recognition of the real pluralism of cultures and ways of life, Professional training of/for bioethicists as partners/trainers who work together with the community to create solutions. Thus, as bioethicists, we create new educational and cultural programmes based on the knowledge gained through the integration of previous projects in various layers of society. They stimulate ethical and creative thinking, create conditions for team learning and encourage people in teams to find innovative ways of operating in contexts of high uncertainty and complexity of the 21st century. We therefore assume that bioethicists, as agents of change, are able to operate on various educational levels (starting from the primary level), contributing to increasing awareness and tolerance of one country’s population by communicating key bioethical messages. The purpose of bioethicists as educational tutors will be not only to understand the social and psychological sources of xenophobia and discrimination manifestations, but also to corroborate existing negative attitudes and stereotypes prevalent in the modern society.Item Association of blood homocysteine levels with C677T and A1298C MTHFR gene polymorphisms in patients with NASH(Turkish Society of Gastroenterology, 2019) Кучма, Наталія Григорівна; Кучма, Наталья Григорьевна; Kuchma, Nataliia HryhorivnaPatients with NASH, which were homozygous for the T677T genotype of the MTHFR gene, had a significantly higher homocysteine plasma level. The MTHFR C677T polymorphisms may be genetic risk factors for the development of NASH.Item Association of Arg389Gly polymorphism of ADRβ1 gene and T393C of GNAS1 gene with risk of development of acute coronary syndrome in patients with arterial hypertension(Lithuanian University of Health Sciences, 2020) Дудченко, Ірина Олександрівна; Дудченко, Ирина Александровна; Dudchenko, Iryna Oleksandrivna; Приступа, Людмила Никодимівна; Приступа, Людмила Никодимовна; Prystupa, Liudmyla Nykodymivna; Фадєєва, Ганна Анатоліївна; Фадеева, Анна Анатольевна; Fadieieva, Hanna Anatoliivna; Moіseienko, Iryna Olehivna; Бондаркова, Анна Миколаївна; Бондаркова, Анна Николаевна; Bondarkova, Anna Mykolaivna; Кучма, Наталія Григорівна; Кучма, Наталья Григорьевна; Kuchma, Nataliia Hryhorivna; Орловський, Олександр Вікторович; Орловский, Александр Викторович; Orlovskyi, Oleksandr Viktorovych; Моісеєнко, Ірина Олегівна; Моисеенко, Ирина ОлеговнаIn our study, we discovered the relationship of the Arg389Gly polymorphism of the ADRβ1 gene and the T393C polymorphism of the GNAS1 gene with the risk of ACS development in the Ukrainian population. Carriers of the Arg389 allele of the polymorphism of the ADRβ1 gene and the C393 allele of the polymorphism of the GNAS1 gene showed a higher risk of ACS development relative to the opposite alleles in these gene polymorphisms.Item The impact of systemic inflammation on anemia in patients with chronic obstructive pulmonary disease(Aluna Publishing, 2020) Ковчун, Анна Володимирівна; Ковчун, Анна Владимировна; Kovchun, Anna Volodymyrivna; Сміянов, Владислав Анатолійович; Смиянов, Владислав Анатольевич; Smiianov, Vladyslav Anatoliiovych; Кучма, Наталія Григорівна; Кучма, Наталья Григорьевна; Kuchma, Nataliia Hryhorivna; Качковська, Владислава Володимирівна; Качковская, Владислава Владимировна; Kachkovska, Vladyslava Volodymyrivna; Приступа, Людмила Никодимівна; Приступа, Людмила Никодимовна; Prystupa, Liudmyla NykodymivnaМетою нашої роботи було вивчити зміст показників системного запалення у хворих на ХОЗЛ залежно від наявності або відсутності АХЗ. Матеріали і методи дослідження. Було обстежено 202 пацієнтів із ХОЗЛ, у дослідження було включено 144 хворих на ХОЗЛ без анемії (гемоглобін ˃120 г/л для жінок і ˃ 130 г/л для чоловіків), які склали 1 групу і 33 хворих на ХОЗЛ з АХЗ (гемоглобін <120 г/л для жінок і <130 г/л для чоловіків, розчинні трансферрінових рецептори (рТФР) - 8,7 – 28,1 нмоль/л), які склали 2 групу. До групи контролю включили 62 практично здорові людини. Усім хворим проводили визначення вмісту феритину, С-реактивного протеїну (СРП) і гепсидину. Статистичну обробку результатів проводили з використанням програми SPSS-21. Результати. Хворі на ХОЗЛ з АХЗ мають достовірно (р <0,001) вищий вміст феритину, порівняно з хворими на ХОЗЛ без анемії і пацієнтами контрольної групи. Вміст С-РП і гепсидину у пацієнтів з ХОЗЛ із АХЗ був також вірогідно вищим порівняно з пацієнтами без анемії та контрольної групи. Висновки. Визначення вмісту феритину, C-РП і гепсидину у пацієнтів із ХОЗЛ може дозволити своєчасно призначити адекватне лікування для цієї групи хворих.Item Роль маркерів хронічного запалення в прогресуванні неалкогольної жирової хвороби печінки(Сумський державний університет, 2012) Кучма, Наталія Григорівна; Кучма, Наталья Григорьевна; Kuchma, Nataliia Hryhorivna