Видання зареєстровані авторами шляхом самоархівування
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Item Positive Association between EDN1 rs5370 (Lys198Asn) Polymorphism and Large Artery Stroke in a Ukrainian Population(Hindawi ''Disease Markers'', 2018) Дубовик, Євген Іванович; Дубовик, Евгений Иванович; Dubovyk, Yevhen Ivanovych; Олешко, Тетяна Богданівна; Олешко, Татьяна Богдановна; Oleshko, Tetiana Bohdanivna; Гарбузова, Вікторія Юріївна; Гарбузова, Виктория Юрьевна; Harbuzova, Viktoriia Yuriivna; Атаман, Олександр Васильович; Атаман, Александр Васильевич; Ataman, Oleksandr VasylovychAs it is well known, endothelial dysfunction plays an important role in the development of common cardiovascular diseases and their complications. One of the main pathogenetic pathways of endothelial dysfunction development is an increased formation and biological activity of the powerful vasoconstrictor and proinflammatory peptide endothelin (ET-1), which mediates own effects via two pharmacologically distinguishable receptor subtypes, endothelin A (ETA) and endothelin B (ETB) receptors, respectively.