Positive Association between EDN1 rs5370 (Lys198Asn) Polymorphism and Large Artery Stroke in a Ukrainian Population
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Date
2018
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Hindawi ''Disease Markers''
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Abstract
As it is well known, endothelial dysfunction plays an important role in the development of common cardiovascular
diseases and their complications. One of the main pathogenetic pathways of endothelial dysfunction development
is an increased formation and biological activity of the powerful vasoconstrictor and proinflammatory peptide
endothelin (ET-1), which mediates own effects via two pharmacologically distinguishable receptor subtypes,
endothelin A (ETA) and endothelin B (ETB) receptors, respectively.
Keywords
інсульт, инсульт, stroke
Citation
Positive Association between EDN1 rs5370 (Lys198Asn) Polymorphism and Large Artery Stroke in a Ukrainian Population / Ye.I. Dubovyk , T.B. Oleshko, V.Yu. Harbuzova, A.V. Ataman // Disease Markers. - 2018. - Volume 2018. - Article ID 1695782. - 9 pages.