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Title Positive Association between EDN1 rs5370 (Lys198Asn) Polymorphism and Large Artery Stroke in a Ukrainian Population
Authors Dubovyk, Yevhen Ivanovych  
Oleshko, Tetiana Bohdanivna  
Harbuzova, Viktoriia Yuriivna  
Ataman, Oleksandr Vasylovych  
Keywords інсульт
инсульт
stroke
Type Article
Date of Issue 2018
URI https://essuir.sumdu.edu.ua/handle/123456789/80871
Publisher Hindawi ''Disease Markers''
License In Copyright
Citation Positive Association between EDN1 rs5370 (Lys198Asn) Polymorphism and Large Artery Stroke in a Ukrainian Population / Ye.I. Dubovyk , T.B. Oleshko, V.Yu. Harbuzova, A.V. Ataman // Disease Markers. - 2018. - Volume 2018. - Article ID 1695782. - 9 pages.
Abstract As it is well known, endothelial dysfunction plays an important role in the development of common cardiovascular diseases and their complications. One of the main pathogenetic pathways of endothelial dysfunction development is an increased formation and biological activity of the powerful vasoconstrictor and proinflammatory peptide endothelin (ET-1), which mediates own effects via two pharmacologically distinguishable receptor subtypes, endothelin A (ETA) and endothelin B (ETB) receptors, respectively.
Appears in Collections: Наукові видання (МІ)

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