Навчально-науковий медичний інститут (НН МІ)
Permanent URI for this communityhttps://devessuir.sumdu.edu.ua/handle/123456789/40
Browse
2 results
Search Results
Item Management aspects of children's health: dysplastic-dependent pathology of the bronchopulmonary system and ecological heterogeneity of the environment(Azerbaijan Medical Journal, 2022) Деміхов, Олексій Ігорович; Demikhov, Oleksii Ihorovych; Dehtyarova, I.; Motrechko, V.; Коленко, Оксана Іванівна; Kolenko, Oksana Ivanivna; Yurchenko, Alla Vladyslavivna; Юрченко, Алла Владиславівна; Деміхова, Надія Володимирівна; Demikhova, Nadiia Volodymyrivna; Kroitor, V.Population stratification of the pediatric population was performed in the study, taking into account a set of regional-ecological factors relevant for the assessment of the health of children with dysplastic-dependent pathology of the bronchopulmonary system. The study was conducted using methods of systematic population modeling of a multi-factorial public health system under the influence of regional and ecologic factors. For each of the 30 environmental factors we have studied, its prognostic value, pathometric and sanologic value have been determined, which ensured the performance of population-personalized risk assessment of the dysplastic-dependent pathology of the bronchopulmonary system.A new methodology for environmental quality assessment has been substantiated, proposed and tested, the application of which allows to determine the differentiation of regional preventive programs of bronchopulmonary dysplasia and the dysplastic-dependent pathology of the bronchopulmonary system in childhood. Personalized regional population stratification of children with bronchopulmonary dysplasia and the dysplastic-dependent pathology of the bronchopulmonary system were performed, and regional clusters (administrative districts of the regions) were identified with an alternative level of environmental quality. The use of pathometric and sanometric assessments (different levels) of environmental factors can be significant to substantiate the structure of targeted health, social, and regional environmental programs for promoting the health of the pediatric population.Item Chronic inflammation and progression of chronic kidney disease in patients with type 2 diabetes(State Institution "Institute of Nephrology NAMS of Ukraine", 2021) Мазур, Тетяна Станіславівна; Мазур, Татьяна Станиславовна; Mazur, Tetiana Stanislavivna; Деміхова, Надія Володимирівна; Демихова, Надежда Владимировна; Demikhova, Nadiia Volodymyrivna; Руденко, Тетяна Миколаївна; Руденко, Татьяна Николаевна; Rudenko, Tetiana Mykolaivna; Юрченко, Алла Владиславівна; Юрченко, Алла Владиславовна; Yurchenko, Alla Vladyslavivna; Єжова, Ольга Олександрівна; Ежова, Ольга Александровна; Yezhova, Olha Oleksandrivna; Бокова, Світлана Іванівна; Бокова, Светлана Ивановна; Bokova, Svitlana Ivanivna; Деміхов, Олексій Ігорович; Демихов, Алексей Игоревич; Demikhov, Oleksii IhorovychChronic inflammation, atherosclerosis, tubulointerstitial fibrosis, and vascular damage play a crucial role in the progression of chronic kidney disease (CKD) in patients with type 2 diabetes mellitus (DM). However, specific biomarkers that can determine the progression of diabetic kidney disease, including patients with minimal albuminuria, remain undefined. The present study aimed to determine markers of chronic inflammation as indicators of CKD progression in patients with type 2 DM. Methods. 45 patients with type 2 DM and stage 1-3 CKD were involved in this cross-sectional observational study. Analysis of cellular mechanisms of CKD progression was performed on the concentrations of endothelin-1 (ET-1), fibronectin (FN), tumor necrosis factor-alpha (TNF-α), transforming growth factor beta-1 (TGF-β1), and monocyte chemoattractant protein (MCP) -1) in the serum. Results. In patients with type 2 DM, an increasing trend in the majority of endothelial and proinflammatory mediators was found according to the CKD stages, despite normal albuminuria. Conclusions. Concentrations of TNF-α, ET, TGF-β1 and MCP-1 can be used to assess the progression of CKD in patients with type 2 DM with normal albuminuria. Further researches are needed to determine early indicators of diabetic kidney disease progression.