Навчально-науковий медичний інститут (НН МІ)
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Item Lymphotropic administration of antibacterial drugs – a method of rational antibiotic therapy(ALUNA Publishing House, 2022) Дужий, Ігор Дмитрович; Дужий, Игорь Дмитриевич; Duzhyi, Ihor Dmytrovych; Шимко, Володимир В'ячеславович; Шимко, Владимир Вячеславович; Shymko, Volodymyr V'iacheslavovych; Олещенко, Галина Павлівна; Олещенко, Галина Павловна; Oleshchenko, Halyna Pavlivna; П'ятикоп, Геннадій Іванович; Пятикоп, Геннадий Иванович; Piatykop, Hennadii IvanovychThe aim: To explore the possibilities of rationalizing antibacterial therapy by comparative analysis of the accumulation of ceftriaxone administered lymphotropically and intramuscularly. Materials and methods: The research used a method of studying the sensitivity of microorganisms to antibacterial drugs, which is based on the diffusion of antibacterial drugs from the carrier (homogenate of the test organ) in a dense nutrient medium, which, depending on the sensitivity of microorganisms, inhibits the growth of the studied culture and is accompanied by the formation of a growth inhibition zone (GIZ) in the nutrient medium. For control purposes, a commercial disk with ceftriaxone was used, which caused GIZ of microorganisms at the level of 27.05 ± 0.9 mm. Results: The homogenate of organ samples obtained from rabbits administered with the antibiotic lymphotropically, inhibited the growth of test cultures around the discs in all cases. The inhibition was slightly less than the control inoculation, but the result clearly indicated the presence of antibiotics in the test material in the quantity sufficient to inhibit the growth of the pathogen. Concurrently, after intramuscular administration of the antibiotic, biopsy specimens from various growth inhibition organs of test cultures were either not induced at all or were induced in small amounts, which was certainly insufficient for the inhibitory action of the drug administered by this method. Conclusions: The administration of the antibiotic lymphotropically promotes its accumulation in all organs in the quantity sufficient for antibacterial action, which allows us to recommend lymphotropic therapy as a rational method of antibiotic therapy.Item Familial tuberculosis and its prevention in terms of health care restructuring(ALUNA Publishing House, 2022) Дужий, Ігор Дмитрович; Дужий, Игорь Дмитриевич; Duzhyi, Ihor Dmytrovych; Олещенко, Галина Павлівна; Олещенко, Галина Павловна; Oleshchenko, Halyna Pavlivna; Бондаренко, Л.А.Aim: To study the peculiarities of the course of familial tuberculosis, which includes tuberculosis revealed in someone in the family if there is a source of this infection. M aterials and methods: We studied 199 families. One member of each family contracted pulmonary tuberculosis and later became a source of the disease for contactees. The examination was performed with standard clinical techniques using radiological, bacteriological, and immunological examination techniques. Results: We found that in 12-24 months, 207 people were diseased in these families. We also revealed the shift toward a younger age among the diseased contactees. Special emphasis should be paid to the disease of children under 18–52 people, while there was only one patient among the sources of tuberculosis. There were more cases of familial tuberculosis in urban than in rural areas. Females were more likely to suffer from these forms of tuberculosis. Conclusions: Considering the above, we believe that the development of familial tuberculosis occurs due to closer contact of TB source patients with family members, which is facilitated by bad habits of source patients and lack of isolation of contactees from sources and ill-considered reform of health care in general and tuberculosis particularly.Item Familial Tuberculosis and its Prevention in Terms of Health Care Restructuring(Aluna Publishing, 2022) Дужий, Ігор Дмитрович; Дужий, Игорь Дмитриевич; Duzhyi, Ihor Dmytrovych; Олещенко, Галина Павлівна; Олещенко, Галина Павловна; Oleshchenko, Halyna Pavlivna; Бондаренко, Леонід Анатолійович; Бондаренко, Леонид Анатольевич; Bondarenko, Leonid Anatoliiovych; Кобилецький, Сергій Миколайович; Кобылецкий, Сергей Николаевич; Kobyletskyi, Serhii MykolaiovychAim: To study the peculiarities of the course of familial tuberculosis, which includes tuberculosis revealed in someone in the family if there is a source of this infection. Materials and methods: We studied 199 families. One member of each family contracted pulmonary tuberculosis and later became a source of the disease for contactees. The examination was performed with standard clinical techniques using radiological, bacteriological, and immunological examination techniques. Results: We found that in 12-24 months, 207 people were diseased in these families. We also revealed the shift toward a younger age among the diseased contactees. Special emphasis should be paid to the disease of children under 18–52 people, while there was only one patient among the sources of tuberculosis. There were more cases of familial tuberculosis in urban than in rural areas. Females were more likely to suffer from these forms of tuberculosis. Conclusions: Considering the above, we believe that the development of familial tuberculosis occurs due to closer contact of TB source patients with family members, which is facilitated by bad habits of source patients and lack of isolation of contactees from sources and ill-considered reform of health care in general and tuberculosis particularly.