Навчально-науковий медичний інститут (НН МІ)
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Item Lymphotropic administration of antibacterial drugs – a method of rational antibiotic therapy(ALUNA Publishing House, 2022) Дужий, Ігор Дмитрович; Дужий, Игорь Дмитриевич; Duzhyi, Ihor Dmytrovych; Шимко, Володимир В'ячеславович; Шимко, Владимир Вячеславович; Shymko, Volodymyr V'iacheslavovych; Олещенко, Галина Павлівна; Олещенко, Галина Павловна; Oleshchenko, Halyna Pavlivna; П'ятикоп, Геннадій Іванович; Пятикоп, Геннадий Иванович; Piatykop, Hennadii IvanovychThe aim: To explore the possibilities of rationalizing antibacterial therapy by comparative analysis of the accumulation of ceftriaxone administered lymphotropically and intramuscularly. Materials and methods: The research used a method of studying the sensitivity of microorganisms to antibacterial drugs, which is based on the diffusion of antibacterial drugs from the carrier (homogenate of the test organ) in a dense nutrient medium, which, depending on the sensitivity of microorganisms, inhibits the growth of the studied culture and is accompanied by the formation of a growth inhibition zone (GIZ) in the nutrient medium. For control purposes, a commercial disk with ceftriaxone was used, which caused GIZ of microorganisms at the level of 27.05 ± 0.9 mm. Results: The homogenate of organ samples obtained from rabbits administered with the antibiotic lymphotropically, inhibited the growth of test cultures around the discs in all cases. The inhibition was slightly less than the control inoculation, but the result clearly indicated the presence of antibiotics in the test material in the quantity sufficient to inhibit the growth of the pathogen. Concurrently, after intramuscular administration of the antibiotic, biopsy specimens from various growth inhibition organs of test cultures were either not induced at all or were induced in small amounts, which was certainly insufficient for the inhibitory action of the drug administered by this method. Conclusions: The administration of the antibiotic lymphotropically promotes its accumulation in all organs in the quantity sufficient for antibacterial action, which allows us to recommend lymphotropic therapy as a rational method of antibiotic therapy.Item Comparison of antibiotic accumulation in appendix with various methods of its injection(Bangladesh Academy of Sciences, 2021) Дужий, Ігор Дмитрович; Дужий, Игорь Дмитриевич; Duzhyi, Ihor Dmytrovych; Шимко, Володимир В'ячеславович; Шимко, Владимир Вячеславович; Shymko, Volodymyr V'iacheslavovych; Pustovoy, I.A.; П'ятикоп, Геннадій Іванович; Пятикоп, Геннадий Иванович; Piatykop, Hennadii Ivanovych; Kuprienko, V.V.; Kulahina, U.E.Relevance of the problem: In respect that, lack dynamic of morbidity incidence of acute appendicitis and frequency of postoperative complications, against the backdrop of increasing the number of antibiotics. The problem of prevention of purulent-inflammatory complications during its surgical treatment remains relevant. Materials and methods: The authors compared the intensity of accumulation of ceftriaxone in the appendix tissues depending on the method of injection. Results: It turned out that with the intramuscular injection of ceftriaxone in 1–2 hours before the operation, its accumulation in appendix in an amount sufficient to delay the growth of the laboratory culture of Escherichia coli is not observed. After intravenous injection of the drug, accumulation occurs slowly, significantly far behind to the lymphotropic technique. With the lymphotropic injection of ceftriaxone, 1 hour before the operation, a dose of growth retardant culture test is already fixed, and with the intjection of 2 hours before the operation – the dose of ceftriaxone practically corresponds to the maximum possible, that is, the action of a “pure” antibacterial drug. Conclusions: The method of selecting antibiotic therapy for acute appendicitis is the introduction of ceftriaxone by lymphotropic route.