Навчально-науковий медичний інститут (НН МІ)
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Item Immunohistochemical characteristics of aortic valve in the case of atherocalcinosis(Springer, 2017) Романюк, Анатолій Миколайович; Романюк, Анатолий Николаевич; Romaniuk, Anatolii Mykolaiovych; Москаленко, Роман Андрійович; Москаленко, Роман Андреевич; Moskalenko, Roman Andriiovych; Закорко, Інна-Маргарита Сергіївна; Закорко, Инна-Маргарита Сергеевна; Zakorko, Inna-Marharyta Serhiivna; Линдін, Микола Сергійович; Лындин, Николай Сергеевич; Lyndin, Mykola Serhiiovych; Піддубний, Артем Михайлович; Поддубный, Артем Михайлович; Piddubnyi, Artem Mykhailovych; Сікора, Владислав Володимирович; Сикора, Владислав Владимирович; Sikora, Vladyslav Volodymyrovych; Линдіна, Юлія Миколаївна; Лындина, Юлия Николаевна; Lyndina, Yuliia Mykolaivna; Romaniuk, S.A.; Ящішин, Ігор Олександрович; Ящишин, Игорь Александрович; Yashchishyn, Ihor OleksandrovychObjective: According to the results of the Euro-Heart Survey on Vascular Heart Disease the most common pathology is nonrheumatic aortic stenosis, it is also called as calcific aortic valve stenosis (CAVS), as in its pathogenesis the process of biomineralization of valve cusps and ring plays the main role.Item Immunohistochemical characteristics of aortic valve in the case of atherocalcinosis(Springer, 2017) Романюк, Анатолій Миколайович; Романюк, Анатолий Николаевич; Romaniuk, Anatolii Mykolaiovych; Москаленко, Роман Андрійович; Москаленко, Роман Андреевич; Moskalenko, Roman Andriiovych; Закорко, Інна-Маргарита Сергіївна; Закорко, Инна-Маргарита Сергеевна; Zakorko, Inna-Marharyta Serhiivna; Линдін, Микола Сергійович; Лындин, Николай Сергеевич; Lyndin, Mykola Serhiiovych; Піддубний, Артем Михайлович; Поддубный, Артем Михайлович; Piddubnyi, Artem Mykhailovych; Линдіна, Юлія Миколаївна; Лындина, Юлия Николаевна; Lyndina, Yuliia Mykolaivna; Романюк, Софія Анатоліївна; Романюк, София Анатольевна; Romaniuk, Sofiia Anatoliivna; Ящішин, Ігор Олександрович; Ящишин, Игорь Александрович; Yashchishyn, Ihor OleksandrovychObjective: According to the results of the Euro-Heart Survey on Vascular Heart Disease the most common pathology is nonrheumatic aortic stenosis, it is also called as calcific aortic valve stenosis (CAVS), as in its pathogenesis the process of biomineralization of valve cusps and ring plays the main role Method: 30 samples of mineralized aortic valves (I group) and 10 samples of aortic valve without evidence of biomineralization (II group - control) were studied. Immunohistochemical study of expression of collagen I, CD68, MPO, S100A9), caspase3 andosteopontin was conducted in AV tissue of both groups. Results: In CAV tissues the fibrillar component (collagen I) growths was found, but the quantitative compositions of circulating inflammatory cells (CD68+) are not significantly different from the control group. CAVs contain much more MPO+ -cells (p< 0.001) in comparison to the group of AV without biomineralization. Our data show a significant increase of the S100A9 and OPN expression in the mineralized tissue of AVs (p < 0.01). Also a higher expression level of Casp3 and MPO was found in CAVs (p< 0.05). Conclusion: High Casp 3 expression confirms the increased level o f cell elimination in the CAVs tissue, which is obviously connected with the impact of high local concentrations ofS100A9. These facts can contribute to the development of pathological biomineralization o f AV. Since osteopontin inhibits the hydroxyapatite formation by binding to the surface of the crystals, its hyperproduction is a counteracting factor against biomineralization in AV tissue.