Навчально-науковий медичний інститут (НН МІ)
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Item Long-term blood pressure variability in strength and endurance professional athletes with office prehypertension over annual training macrocycle(Tbilisi State Medical University, 2022) Атаман, Юрій Олександрович; Атаман, Юрий Александрович; Ataman, Yurii Oleksandrovych; Бріжата, Ірина Анатоліївна; Брижата, Ирина Анатольевна; Brizhata, Iryna Anatoliivna; Жаркова, Альбiна Володимирiвна; Жаркова, Альбина Владимировна; Zharkova, Albina Volodymyrivna; Моісеєнко, Ірина Олегівна; Моисеенко, Ирина Олеговна; Moiseyenko, Iryna Olehivna; Овечкін, Денис Вячеславович; Овечкин, Денис Вячеславович; Ovechkin, Denys ViacheslavovychConsidering the high spreading of arterial hypertension (AH) in professional athletes involved in different types of physical activities, as well as the high probability of its development in individuals with high normal blood pressure (BP), we aimed at investigating the daily profile of BP during three periods of annual training summer macrocycle: the preparation, competitive and transition ones. The investigation included 30 athletes having levels of systolic BP ≥130 and <140; as well as diastolic BP ≥ 85 and <90 mmHg during a thorough office examination in the preparation phase, who were divided into two groups without changes on age, sex, the duration of the sporting career depending on the type of a performed physical activity - strength (Str) and endurance (End). The athletes underwent office BP measurements and home BP monitoring (over the course of 3-7 days (M=5.2 (0.9) days), medical consultations, anthropometric and clinical examinations on each phase of the macrocycle. Although symptoms of chronic stress and autonomic dysfunction were quite common in athletes with prehypertension, still the emergence of the detected symptoms didn't differ significantly between two groups under investigation. When comparing the average values of office and home BP, the differences between Str-group and End-group regarding all indicators during the competitive phase have been identified. In particular, the levels of home diastolic BP differ the most - in Str-group they amounted to 91.1 (5.5) mm Hg, whereas in Endgroup to 83.7 (5.9) mm Hg (р=0.002). Nevertheless, the average maximum home systolic BP in Str-group has exceeded the high normal limit and accounted for 142.5 (10.2) mm Hg, in End-group the same parameter was 133.1 (7.6) mm Hg (р=0.019). The spreading of hypertension during preparation, competitive and transition periods in the Str-group has consecutively accounted for 20%, 53.3% and 13.3%.; in End-group the BP has accounted for 6.7%, 13.3% and 6.7% respectively, herewith during the competitive phase that indicator in Str-group was much higher (р=0.02), and the relative risk of developing hypertension during the competitive phase equaled 4 (р=0.048). Therefore, the increase of AH frequency and the level of BP in athletes involved in strength exercises isn't supported by an increase of autonomic symptoms development in comparison to the athletes performing endurance exercises, i.e. the frequency of asymptomatic, masked cases has a tendency to rise. To detect hypertension in time, we suggest performing home BP monitoring for athletes with high normal blood pressure during the competitive period.Item Oxidative stress as a factor in the deterioration of oxygen transfer during exercise(National Academy of Sciences of Ukraine, Bogomoletz Institute of Physiology, 2021) Gunina, L.M.; Rybina, I.L.; Атаман, Юрій Олександрович; Атаман, Юрий Александрович; Ataman, Yurii Oleksandrovych; Voitenko, V.L.Blood oxygen transport regulation by physical activity increase within training dynamics is provided with different mechanisms: from the quantitative and qualitative erythron restructure (including endogenous erythropoietin rise and main erythrocyte index shifts) to change in haemoglobin affinity to oxygen, its heterogeneous structure and blood flow growth as a result of endothelium hyperpolarisation. However, the erythrocyte itself remains a key performer in blood velocity control, due to its structure and functions. This review summarizes the data of modern scientific literature on the characteristics of erythrocytes, which make these cells one of the key links in the oxygen transport system of the blood. The focus on this property of erythrocytes during physical activity is based on the fact that the athlete’s muscles must be supplied with enough oxygen to ensure high performance. Specific training and extra-training factors affecting the content of erythrocytes have been determined. The membrane structure is treated as a significant erythrocyte part in determining its deformation and microvascular blood transport. Enzymes associated with the erythrocyte membrane and affecting cell viability and performance are described. Besides, it is stressed on monitoring erythrocyte indices via modern equipment and assessing lipid peroxidation, which leads to disorders in erythrocyte membrane structure and functions.Item Structural and functional features of myocardial remodeling in professional athletes(Сумський державний університет, 2018) Атаман, Юрій Олександрович; Атаман, Юрий Александрович; Ataman, Yurii Oleksandrovych; Vorozhko, O.A.; Voloshin, O.S.Item K121Q Polymorphism of the ENPP1 gene is related to acute coronary syndrome in Ukrainian patients with normal but not enhanced body mass index(Science Publications, 2015) Розуменко, Інна Олександрівна; Розуменко, Инна Александровна; Rozumenko, Inna Oleksandrivna; Гарбузова, Вікторія Юріївна; Гарбузова, Виктория Юрьевна; Harbuzova, Viktoriia Yuriivna; Атаман, Юрій Олександрович; Атаман, Юрий Александрович; Ataman, Yurii Oleksandrovych; Атаман, Олександр Васильович; Атаман, Александр Васильевич; Ataman, Oleksandr VasylovychEctonucleotide Pyrophosphatase Phosphodiesterase 1 (ENPP1) is a class II membrane glycoprotein with two unrelated properties: It can hydrolyze extracellular nucleotides and downregulate insulin receptor signaling. The present study was carried out to investigate whether common single-nucleotide polymorphism K121Q (rs1044498) of the ENPP1 gene is associated with Acute Coronary Syndrome (ACS) in the representatives of Ukrainian population and to assess if the risk depends on gender and Body Mass Index (BMI). A total 228 DNA samples (118 ACS patients and 110 control subjects) were genotyped for the polymorphism by PCR and restriction fragment length polymorphism method. No associations between the K121Q polymorphisms and ACS were found neither on the whole nor taking into account the gender. However, in the persons with BMI <25 kg/m2 but not with overweight, genotypes with the minor allele (KQ + QQ) were significantly associated with ACS (OR 3.939, 95% CI 1.148-13.524, P = 0.029). Genotypes with minor allele can be a possible genetic risk factor for ACS in persons with BMI <25 kg/m2. It is likely that these genotypes affect ACS not by the traditional risk factors (overweight/obesity, insulin resistance and type 2 diabetes) but by direct or undirect influence on pathologic processes in the wall of the coronary vessels (atherosclerosis and arterial calcification).Item Investigation of the MGP promoter and exon 4 polymorphisms in patients with ischemic stroke in the Ukrainian population(Haliç University, Printed in Turkey, 2012) Обухова, Ольга Анатоліївна; Обухова, Ольга Анатольевна; Obukhova, Olha Anatoliivna; Гарбузова, Вікторія Юріївна; Гарбузова, Виктория Юрьевна; Harbuzova, Viktoriia Yuriivna; Атаман, Олександр Васильович; Атаман, Александр Васильевич; Ataman, Oleksandr Vasylovych; Атаман, Юрій Олександрович; Атаман, Юрий Александрович; Ataman, Yurii Oleksandrovych; Matlaj, O.I.Matrix γ-carboxyglutamic acid protein (MGP) is a vitamin K-dependent protein playing a pivotal role in preventing arterial calcification. In the present study, we aimed to investigate the relation between three single nucleotide polymorphisms of MGP gene and ischemic stroke (IS) in the Ukrainian population. 170 IS patients and 124 healthy controls were recruited to the study. MGP SNPs were examined by PCR-RFLP methodology. The distribution of homozygous carriers of the major allelic variant, and heterozygous and homozygous minor allele variants of the T-138C MGP promoter polymorphism (rs1800802) in patients with IS was 61.2%, 31.2% and 7.6%, respectively. The corresponding distributions of the variants in the control group were 59.7%, 35.6%, 4.8%. With regard to the G-7A promoter polymorphism (rs1800801), the respective distributions were 35.9%, 48.8% and 15.3%, compared to 43.5%, 50% and 6.5% in the control group. Finally, the respective distributions according to the Thr83Ala exon 4 polymorphism (rs4236) were 39.4%, 48.8% and 11.8%, compared to 34.7%, 53.2% and 12.1% in the control group. Using logistic regression analysis, it was estimated that A/A genotype (G-7A polymorphism) was significantly (P=0.016) associated with IS (OR=2.943; 95% CI: 1.218–7.109) in the Ukrainian population. A-allele homozygotes of female sex had a risk of IS more than 7 times higher compared with carriers of G/G genotype.Item Course of myocardial infarction in patients with concomitant arterial hypertension(Видавництво СумДУ, 2011) Атаман, Юрій Олександрович; Атаман, Юрий Александрович; Ataman, Yurii Oleksandrovych; Zakorko, I.-M.; Masko, A.Item Clinical features of patients with posterior wall myocardial infarction, complicated by the right ventricule injury(Видавництво СумДУ, 2010) Атаман, Юрій Олександрович; Атаман, Юрий Александрович; Ataman, Yurii Oleksandrovych; Brezme, O.According to the literature the frequency of expansion of posterior wall myocardial infarction (MI) to the right ventricle reaches 25%. At the same, the relevance of timely diagnosis of this clinical condition is due to the complexity of its implementation and the fact that treatment of right ventricle MI has a number of significant features (significantly limiting the indications of nitropreparates, ACE inhibitors and other vasodilatators, particularly relevant reperfusion therapy and efforts to reduce complications). The object of our research was to study clinical and functional characteristics of patients with posterior wall MI complicated by the right ventricle injury. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/6756