Навчально-науковий медичний інститут (НН МІ)
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Item Lymphotropic administration of antibacterial drugs – a method of rational antibiotic therapy(ALUNA Publishing House, 2022) Дужий, Ігор Дмитрович; Дужий, Игорь Дмитриевич; Duzhyi, Ihor Dmytrovych; Шимко, Володимир В'ячеславович; Шимко, Владимир Вячеславович; Shymko, Volodymyr V'iacheslavovych; Олещенко, Галина Павлівна; Олещенко, Галина Павловна; Oleshchenko, Halyna Pavlivna; П'ятикоп, Геннадій Іванович; Пятикоп, Геннадий Иванович; Piatykop, Hennadii IvanovychThe aim: To explore the possibilities of rationalizing antibacterial therapy by comparative analysis of the accumulation of ceftriaxone administered lymphotropically and intramuscularly. Materials and methods: The research used a method of studying the sensitivity of microorganisms to antibacterial drugs, which is based on the diffusion of antibacterial drugs from the carrier (homogenate of the test organ) in a dense nutrient medium, which, depending on the sensitivity of microorganisms, inhibits the growth of the studied culture and is accompanied by the formation of a growth inhibition zone (GIZ) in the nutrient medium. For control purposes, a commercial disk with ceftriaxone was used, which caused GIZ of microorganisms at the level of 27.05 ± 0.9 mm. Results: The homogenate of organ samples obtained from rabbits administered with the antibiotic lymphotropically, inhibited the growth of test cultures around the discs in all cases. The inhibition was slightly less than the control inoculation, but the result clearly indicated the presence of antibiotics in the test material in the quantity sufficient to inhibit the growth of the pathogen. Concurrently, after intramuscular administration of the antibiotic, biopsy specimens from various growth inhibition organs of test cultures were either not induced at all or were induced in small amounts, which was certainly insufficient for the inhibitory action of the drug administered by this method. Conclusions: The administration of the antibiotic lymphotropically promotes its accumulation in all organs in the quantity sufficient for antibacterial action, which allows us to recommend lymphotropic therapy as a rational method of antibiotic therapy.Item Familial tuberculosis and its prevention in terms of health care restructuring(ALUNA Publishing House, 2022) Дужий, Ігор Дмитрович; Дужий, Игорь Дмитриевич; Duzhyi, Ihor Dmytrovych; Олещенко, Галина Павлівна; Олещенко, Галина Павловна; Oleshchenko, Halyna Pavlivna; Бондаренко, Л.А.Aim: To study the peculiarities of the course of familial tuberculosis, which includes tuberculosis revealed in someone in the family if there is a source of this infection. M aterials and methods: We studied 199 families. One member of each family contracted pulmonary tuberculosis and later became a source of the disease for contactees. The examination was performed with standard clinical techniques using radiological, bacteriological, and immunological examination techniques. Results: We found that in 12-24 months, 207 people were diseased in these families. We also revealed the shift toward a younger age among the diseased contactees. Special emphasis should be paid to the disease of children under 18–52 people, while there was only one patient among the sources of tuberculosis. There were more cases of familial tuberculosis in urban than in rural areas. Females were more likely to suffer from these forms of tuberculosis. Conclusions: Considering the above, we believe that the development of familial tuberculosis occurs due to closer contact of TB source patients with family members, which is facilitated by bad habits of source patients and lack of isolation of contactees from sources and ill-considered reform of health care in general and tuberculosis particularly.Item Familial Tuberculosis and its Prevention in Terms of Health Care Restructuring(Aluna Publishing, 2022) Дужий, Ігор Дмитрович; Дужий, Игорь Дмитриевич; Duzhyi, Ihor Dmytrovych; Олещенко, Галина Павлівна; Олещенко, Галина Павловна; Oleshchenko, Halyna Pavlivna; Бондаренко, Леонід Анатолійович; Бондаренко, Леонид Анатольевич; Bondarenko, Leonid Anatoliiovych; Кобилецький, Сергій Миколайович; Кобылецкий, Сергей Николаевич; Kobyletskyi, Serhii MykolaiovychAim: To study the peculiarities of the course of familial tuberculosis, which includes tuberculosis revealed in someone in the family if there is a source of this infection. Materials and methods: We studied 199 families. One member of each family contracted pulmonary tuberculosis and later became a source of the disease for contactees. The examination was performed with standard clinical techniques using radiological, bacteriological, and immunological examination techniques. Results: We found that in 12-24 months, 207 people were diseased in these families. We also revealed the shift toward a younger age among the diseased contactees. Special emphasis should be paid to the disease of children under 18–52 people, while there was only one patient among the sources of tuberculosis. There were more cases of familial tuberculosis in urban than in rural areas. Females were more likely to suffer from these forms of tuberculosis. Conclusions: Considering the above, we believe that the development of familial tuberculosis occurs due to closer contact of TB source patients with family members, which is facilitated by bad habits of source patients and lack of isolation of contactees from sources and ill-considered reform of health care in general and tuberculosis particularly.Item Impact of clinical forms of pulmonary tuberculosis on the epidemic situation(ALUNA Publishing House, 2021) Дужий, Ігор Дмитрович; Дужий, Игорь Дмитриевич; Duzhyi, Ihor Dmytrovych; Олещенко, Галина Павлівна; Олещенко, Галина Павловна; Oleshchenko, Halyna Pavlivna; Гнатенко, Іван Андрійович; Гнатенко, Иван Андреевич; Hnatenko, Ivan Andriiovych; Бондаренко, Л.А.; Горностаєва, П.О.Overcrowded places cause faster spread of the infection. The consequences of the coronaviruses` mutation show that the transformations can lead to emergencies.Item Gender and age features of «familial» tuberculosis in the Sumy region(ALUNA Publishing House, 2021) Дужий, Ігор Дмитрович; Дужий, Игорь Дмитриевич; Duzhyi, Ihor Dmytrovych; Олещенко, Галина Павлівна; Олещенко, Галина Павловна; Oleshchenko, Halyna Pavlivna; Литвиненко, О.М.; Мельник, В.П.; Бондаренко, Л.А.; Гнатенко, Іван Андрійович; Гнатенко, Иван Андреевич; Hnatenko, Ivan AndriiovychА «typical» example of tuberculosis sources was males aged 42.5 ± 2.4 years. It can be explained by a tendency to smoke and abuse alcohol, which provokes antisocial behavior and low adherence to treatment. The latter contributed to the infection in the vast majority of women and children. Thus, «reforming medicine» by eliminating and reducing the network of anti-tuberculosis hospitals and dispensaries, where such patients would be treated, at least until the cessation of bacterial excretion, and the network of anti-tuberculosis children’s sanatoriums, where children could recover and be isolated from sick adults. , premature.Item Particular qualities of the proteolytic system in patients with tuberculosis depending on the sensitivity of the pathogen(ALUNA PUBLISHING, 2021) Дужий, Ігор Дмитрович; Дужий, Игорь Дмитриевич; Duzhyi, Ihor Dmytrovych; Олещенко, Галина Павлівна; Олещенко, Галина Павловна; Oleshchenko, Halyna Pavlivna; Гнатенко, Іван Андрійович; Гнатенко, Иван Андреевич; Hnatenko, Ivan Andriiovych; Голубничий, Станіслав Олександрович; Голубничий, Станислав Александрович; Holubnychyi, Stanislav OleksandrovychThe aim: Studying the features of the proteolytic system in patients with tuberculosis depending on the sensitivity of the pathogen. Materials and methods: In the course of the research we studied the level of elastase in the blood of 111 patients. The first group consisted of 66 (59.5%) people with pulmonary tuberculosis (39 were sensitive to antibacterial drugs, 27 were resistant). The second group included 13 (11.7%) patients with tuberculous pleurisy. The third group consisted of 32 (28.8%) patients with dual localization of the process (pulmonary tuberculosis and pleural tuberculosis). Results: The level of neutrophil elastase in patients with tuberculous pleurisy (253.2 nmol / min • ml) was 2.2 times higher than in patients with sensitive pulmonary tuberculosis (110.1 nmol / min • ml) and higher than in patients with resistant pulmonary tuberculosis 3.0 times. In combined pulmonary and pleural tuberculosis (third group) the level of elastase was 1.6 times higher than in pulmonary tuberculosis (176.9 nmol / min • ml)) (p <0.01), but lower than in pleurisy in 1, 4 times. In sensitive combined tuberculosis (lungs and pleura) the level of NE was 1.5 times higher than in patients of subgroup 1a (p <0.01) and 1.4 times lower than in patients with tuberculous pleurisy (p <0.01 ). Conclusions: The highest level of elastase in tuberculous pleurisy can be explained by its increased production, contributes to increased “permeability” of the pleural sheets and the accumulation of pleural effusion. In resistant forms of tuberculosis, the immune response in the form of the activity of the proteolytic system, which is lower than in sensitive forms, can be explained by the exhaustion of the immune system under the influence of aggressive tuberculosis. The above can be associated with both the weakening of the patient’s body and the aggressiveness of the pathogen.Item The prevalence of pleural adhesions in patients with pleural effusion syndrome depending on the method of the radiological examination(2018) Олещенко, Галина Павлівна; Олещенко, Галина Павловна; Oleshchenko, Halyna Pavlivna; Романенко, Т.В.We analyzed the medical documentation of 329 patients with pleural effusion syndrome, in 142 of them (the main group), ultrasonoscopy and radiography were used in the primary examination; in 187 (the comparison group), only radiography was used. All patients were examined using thoracoscopy with pleural biopsy.Item The problem of tuberculosis in the Sumy region nowardays(Сумський державний університет, 2018) Олещенко, Галина Павлівна; Олещенко, Галина Павловна; Oleshchenko, Halyna Pavlivna; Гнатенко, Іван Андрійович; Гнатенко, Иван Андреевич; Hnatenko, Ivan AndriiovychThe problem of tuberculosis continues to be very acute and requires considerable attention both from health organizers and from general network physicians, including phthisiologists.Item Features of radiodiagnosis of syndrome of pleural effusion(Sumy State University, 2016) Oleshchenko, Halyna Pavlivna; Voshchenko, V.P.; Diedkova, Kateryna Andriivna; Дєдкова, Катерина Андріївна; Дедкова, Екатерина Андреевна; Олещенко, Галина Павлівна; Олещенко, Галина ПавловнаThe epidemic of tuberculosis, registered in Ukraine in 1995, remains a threat to society. Unfortunately, it cannot be overcomed, despite all the efforts. In the last two decades against the background of a high general incidence of all tuberculosis is more common extrapulmonary localization. Among such form the overwhelming majority - tuberculosis of the pleura. The leading signs of the disease are chest pain, coughing, increasing of shortness of breath, accumulation of pleural effusion.