Навчально-науковий медичний інститут (НН МІ)
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Item Association of blood homocysteine levels with C677T and A1298C MTHFR gene polymorphisms in patients with NASH(Turkish Society of Gastroenterology, 2019) Кучма, Наталія Григорівна; Кучма, Наталья Григорьевна; Kuchma, Nataliia HryhorivnaPatients with NASH, which were homozygous for the T677T genotype of the MTHFR gene, had a significantly higher homocysteine plasma level. The MTHFR C677T polymorphisms may be genetic risk factors for the development of NASH.Item Homocystene and human astrocytes(Сумський державний університет, 2016) Škovierova, H.; Mahmood, S.; Blahovcova, E.; Strnadel, J.; Sopkova, J.; Halašova, E.Astrocytes are multipotent and serve surprisingly large and diverse variety of functions, providing for the overall brain homeostasis, assisting in neurogenesis, determining the microarchitecture of the grey matter, and defending the brain through evolutionary conserved astrogliosis programs. Astrocytes are specifically involved in various neurodegenerative diseases, including Alzheimer’s and Parkinson’s diseases, and various forms of dementia. Homocysteine is a nonessential sulphur-containing amino acid that had been linked with neurodegenerative diseases and aging.