Навчально-науковий медичний інститут (НН МІ)
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Item Morphofunctional reconstructions of the epiphysal-parathyroide axis structural components of rats in the period of readaptation after prolonged exposure to heavy metals(V. Danilevsky institute for endocrine pathology problems of the NAMS of Ukraine, 2020) Гринцова, Наталія Борисівна; Гринцова, Наталия Борисовна; Hryntsova, Nataliia Borysivna; Тимакова, Олена Олександрівна; Тимакова, Елена Александровна; Tymakova, Olena Oleksandrivna; Романюк, Анатолій Миколайович; Романюк, Анатолий Николаевич; Romaniuk, Anatolii MykolaiovychAn important environmental problem is the pollution of the environment with heavy metal salts, which are in various combinations depending on the region and cause adverse effects on public health. The endocrine system together with the immune and nervous system maintains homeostasis in the body. In order to study the morphofunctional rearrangements of the epiphyseal-parathyroid axis structural components in rats during 30 days of readaptation after 90 days of exposure to heavy metal salts (zinc (ZnSO4 · 7H2O) — 5 mg/l, copper (CuSO4 · 5H2O) — 1 mg/l, iron (FeSO4 ) — 10 mg/l, manganese (MnSO4 · 5H2O) — 0.1 mg/l, lead (Pb(NO3 ) 2 ) — 0.1 mg/l and chromium K2Cr2O7) — 0.1 mg/l) an experiment was performed on 24 white sexually mature male rats weighing 250–300 g, aged 7–8 months. The animals of the experimental group consumed ordinary drinking water for 30 days. Morphological, statistical, immunohistochemical and biochemical research methods were used. The 30-day period of readaptation after 90 days of heavy metal salts intake is insufficient to completely restore homeostasis in the epiphyseal-parathyroid system, which is at the stage of chronic stress «subcompensation». Significant morphological changes on the part of the vascular bed of the pineal gland and parathyroid glands (blood stasis, erythrocyte aggregation, sludge phenomenon) were determined, an active glial reaction was formed in the pineal gland, and the structure of the epithelial trabeculae of the glands was disturbed. The levels of parathyroid hormone and calcium in the blood of experimental animals were significantly lower than those of experimental animals. There is a greater vulnerability and faster dynamics of the regenerative processes in the parathyroid glands to the action of salts of heavy metals in comparison with the pineal gland. The development of hypofunction of the parathyroid glands, of course, has a negative effect on the overall calcium metabolism in the body, the development of compensatory and adaptive processes and the course of the general adaptation syndrome in response to the damaging agent.Item Ultraviolet impact on rat skin(Springer, 2020) Сулим, Григорій Анатолійович; Сулим, Григорий Анатольевич; Sulym, Hryhorii Anatoliiovych; Линдін, Микола Сергійович; Лындин, Николай Сергеевич; Lyndin, Mykola Serhiiovych; Сікора, Владислав Володимирович; Сикора, Владислав Владимирович; Sikora, Vladyslav Volodymyrovych; Сікора, Катерина Олексіївна; Сикора, Екатерина Алексеевна; Sikora, Kateryna Oleksiivna; Гирявенко, Наталія Іванівна; Гирявенко, Наталья Ивановна; Hyriavenko, Nataliia Ivanivna; Романюк, Анатолій Миколайович; Романюк, Анатолий Николаевич; Romaniuk, Anatolii MykolaiovychThe aim of our study was to establish a >model imitating of UV-B (wavelength peak is 311 nm) therapy for rat’s skin and to find match macroscopical and following histological skin changes including melanocytes spreading and melanin distribution.Item CEACAM1 expression in the normal uterus of rats(Springer, 2020) Сікора, Катерина Олексіївна; Сикора, Екатерина Алексеевна; Sikora, Kateryna Oleksiivna; Линдін, Микола Сергійович; Лындин, Николай Сергеевич; Lyndin, Mykola Serhiiovych; Кравцова, Ольга Іванівна; Кравцова, Ольга Ивановна; Kravtsova, Olha Ivanivna; Сікора, Владислав Володимирович; Сикора, Владислав Владимирович; Sikora, Vladyslav Volodymyrovych; Романюк, Анатолій Миколайович; Романюк, Анатолий Николаевич; Romaniuk, Anatolii Mykolaiovych; Singer, B.B.The carcinoembryonic antigen-related adhesion molecules (CEACAM) play a significant role in numerous physiological processes, such as cell-cell and cell-ECMadhesion, angiogenesis, proliferation, etc. The objective is characterization of the CEACAM1 expression pattern in normal tissues of rat uterus.