Please use this identifier to cite or link to this item: http://essuir.sumdu.edu.ua/handle/123456789/2703
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Title Chitosan–hydroxyapatite composite biomaterials made by a one step co-precipitation method: preparation, characterization and in vivo tests
Authors Danylchenko, Serhii Mykolaiovych
Kalinkevich, Oksana Vladimirovna
Pogorelov, Maksim Vladimirovich
Keywords biodegradation
chitosan
hydroxyapatite
osteogenesis
scaffolds
Type Article
Date of Issue 2009
URI http://essuir.sumdu.edu.ua/handle/123456789/2703
Publisher Collegium Basilea & AMSI
License
Citation Journal of Biological Physics and Chemistry 9 (2009) 119–126
Abstract A series of biocompatible chitosan/hydroxyapatite composites has been synthesized in an aqueous medium from chitosan solution and soluble precursor salts by a one-step coprecipitation method. The composite materials were produced in dense and porous variants. XRD and IR studies have shown that the apatite crystals in the composites have structural characteristics similar to those of crystals in biogenic apatite. A study of in vivo behaviour of the materials was carried out. Cylindrical rods made of the chitosan/ hydroxyapatite composite material were implanted into the tibial bones of rats. After 5, 10, 15 and 24 days of implantation, histological and histo-morphometric analyses of decalcified specimens were undertaken to evaluate their biocompatibility and the possibility to apply them in bone tissue engineering. The calcified specimens were examined by scanning electron microscopy combined with X-ray microanalysis to compare the elemental composition and morphological characteristics of the implant and the bone during integration. Porous specimens were osteoconducting and were replaced in vivo by newly formed bone tissue. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/2703
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