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Title Giant-cell epulis: immunohistochemical analysis of MGMT, p53, OPN and ММР-1
Other Titles Epulis gigantocelularis: imunohistochemická analýza MGMT, p53, OPN a MMP-1
Authors Kuzenko, Yevhen Viktorovych  
Romaniuk, Anatolii Mykolaiovych  
ORCID http://orcid.org/0000-0003-3985-8912
http://orcid.org/0000-0003-2560-1382
Keywords immunohistochemistry
p53
oral giant-cell epulis
osteopontin
MGMT
ММР-1
Type Article
Date of Issue 2013
URI http://essuir.sumdu.edu.ua/handle/123456789/31872
Publisher Trios
License
Citation Kuzenko, Y. Giant-cell epulis: immunohistochemical analysis of MGMT, p53, OPN and ММР-1 [Text] / Y.Kuzenko., A.Romaniuk // Osteologický bulletin. - 2013. - Vol.18(3). - P. 87–9.
Abstract Object: The object of this study was to analyze the expression of MGMT, p53, OPN and ММР-1 in giant-cell epulis. Methods: 10 giant-cell epulis were evaluated for expression of MGMT, p53, OPN and ММР-1 by immunohistochemistry. Results: Strong giant-cell positivity for MGMT was observed in 96.9±0.5% (P < 0.05). Strong mesenchymal immunoreactivity for MMP-1 was figured in giant-cell, 75.9±1.33% and in the stroma 54.12±1.36% (P<0.05). Immunoreactivity for OPN was fixed in the giant-cell of epulis 15.77±1.8%., positivity for p53 was found in 5.67±0.32% of giant-cell contrast and in the stroma 0%. Conclusion: MGMT, p53 and OPN may play important roles in the biology of giant-cell epulis. Furthermore, the ММР-1 of these proteases at higher levels in giant-cell epulis may help to explain invasion in bone matrix. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/31872
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