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Title The influence of inflammatory infiltration on hsp90α receptor expression in breast cancer tis-sues
Authors Romaniuk, Anatolii Mykolaiovych  
Lyndin, Mykola Serhiiovych  
Karpenko, Liudmyla Ivanivna  
Budko, Hanna Yuriivna  
Lyndina, Yuliia Mykolaivna  
Logvinova, O.
ORCID http://orcid.org/0000-0003-2560-1382
http://orcid.org/0000-0003-4385-3903
http://orcid.org/0000-0002-5274-7021
http://orcid.org/0000-0002-3567-2996
http://orcid.org/0000-0002-2132-0965
Keywords шаперони
шапероны
chaperones
рак молочної залози
рак молочной железы
breast cancer
запальна інфільтрація
воспалительная инфильтрация
inflammatory infiltration
Type Article
Date of Issue 2015
URI http://essuir.sumdu.edu.ua/handle/123456789/42046
Publisher Сумський державний університет
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Citation The influence of inflammatory infiltration on hsp90α receptor expression in breast cancer tis-sues / A. Romaniuk, M. Lуndіn, L. Karpenko [et al.] // Journal of Clinical and Experimental Medical Research. - 2015. - Vol. 3. - Issue 1. - P. 38-43.
Abstract The passing of breast cancer (BC) is dependent on many factors. Presence of inflammatory infiltration in the stroma and its qualitative composition play one of the key roles. Information about its influence is contradictory. On the one hand the reduction of leukocyte infiltra-tion increases the incidence of damage lymph nodes; on the other hand immune microenvironment of tumor determines the proliferative activ-ity, migration and metastasis of cells. Heat shock proteins or chaper-ones are a family of highly conserved intracellular proteins. They are constantly synthesized in normal conditions, but under the stress the synthesis significantly is increased. The influence of inflammation and oxidase stress leads to the synthesis of HSP. Hsp90 is responsible for the conformational maturation and repair of more than 300 intracellu-lar proteins that play an important role in the growth, differentiation and maturation of cells. It is known the influence of chaperone 90 on the stability steroid receptors. Objective of the investigation was the study of Hsp90 synthesis in the presence of inflammatory infiltration in the intercellular neoplastic space and the possibility of its influence on the malignant process. We selected 43 cases of infiltrative ductal carcinoma of different degree of malignancy by Scarff-Bloom-Richardson. The material was divided into two groups. The first group included 24 cases of breast cancer with the presence of leukocyte infiltration in tumor stromal component, the second - 19 cases without inflammatory infiltration in the stroma. Immunohistochemical reaction took place in 2 stages: I – incubated with primary rabbit antibody at a dilution of 1:200; II - in-cubation with secondary antibodies (UltraVision ONE HRP Polymer). Mathematical calculations were done using Microsoft Excel 2010 with AtteStat 12.0.5 option. The presence of inflammatory infiltration in the stromal component of the tumor tissue does not depend on the degree of malignancy of tumor (p>0.05). It was established a correlation between the level of expression chaperones in the epitheliocytes and infiltration of stromal breast cancer tissue (p<0.05). Immune microenvironment stimulates the synthesis in epithelial cells Hsp90α, which may increase their pro-tective properties against the action pharmaceutical preparations and the influence of the macroorganism.
Appears in Collections: Наукові роботи студентів, магістрів, інтернів, аспірантів, клінічних ординаторів (НН МІ)

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