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Title Pathogenetic mechanisms of heavy metals effect on proapoptotic and proliferative potential of breast cancer
Authors Romaniuk, Anatolii Mykolaiovych  
Lyndin, Mykola Serhiiovych  
Moskalenko, Roman Andriiovych  
Kuzenko, Yevhen Viktorovych
Hladchenko, Oksana Robertivna
Gladchenko, Oksana Robertivna
Lyndina, Yuliia Mykolaivna  
Keywords рак молочної залози
рак молочной железы
breast cancer
важких металів
тяжелых металлов
heavy metal
фрагментація ДНК
фрагментация ДНК
DNA fragmentation
проліферація
пролиферация
proliferation
апоптоз
apoptosis
Type Article
Date of Issue 2015
URI http://essuir.sumdu.edu.ua/handle/123456789/42357
Publisher Akadémiai Kiadó, Budapest
License
Citation Pathogenetic mechanisms of heavy metals effect on proapoptotic and proliferative potential of breast cancer / A. Romaniuk, M. Lyndin, R. Moskalenko [et al.] // Interv Med Appl Sci. - 2015. - 7(2). - P. 63–68.
Abstract aterials and Methods:Chemical composition was studied with the help of the scanning electron microscope with energy-dispersion spectrometer. Immunohistochemical reaction showed the p53 and Ki-67 receptors expression. The study of DNA fragmentation was performed in agarose gel. Results:There was an interrelation between the accumulations of the trace elements with the degree of cancer malignancy. There were 85% of cases with positive reaction to Ki-67 and 40% cases with positive reaction to p53. We found a moderate correlation between the accumulation of microelements in the breast cancer tissue and the level of proliferative activity. We noted the combination of the increase of DNA fragmentation with the expression of p53 and Ki-67 receptors. Conclusions:The trace elements can cause the initiation and the progression of the tumorous growth, which is expressed in the increased proliferation of tumor cells. This leads to the destabilization of the genetic material which can be expressed in the synthesis of mutant p53 protein. Finally, it leads to the block of apoptosis and regulatory effects of cells. This can cause the tumor progression and the destabilization of the genome, which is reflected in the increased DNA fragmentation.
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