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Title Structural features of bone marrow
Authors Romaniuk, Anatolii Mykolaiovych  
Lyndina, Yuliia Mykolaivna  
Sikora, Vladyslav Volodymyrovych  
Lyndin, Mykola Serhiiovych  
Karpenko, Liudmyla Ivanivna  
Hladchenko, Oksana Robertivna
Masalitin, I.
Keywords bone marrow
immunohistochemical method
myelopoiesis
erythropoiesis
lymphopoiesis
megalokaryocytes
Type Article
Date of Issue 2016
URI http://essuir.sumdu.edu.ua/handle/123456789/52438
Publisher Interventional Medicine & Applied Science
License
Citation Structural features of bone marrow / A. Romaniuk, Yu. Lyndina, V. Sikora [et al.] // Interventional Medicine & Applied Science. – 2016. - Vol.8(3). - Р. 121-126.
Abstract Purpose. The article is devoted to the investigation of the structural features of the bone marrow of mature rats. Material and Methods. The investigation of the structural features of the bone marrow was performed on the femurs of mature male rats. General structure of the organ was studied with hematoxylin-eosin and Van Gieson staining of samples. Certain features of the bone marrow structure were studied using immunohistochemical method (CD3, CD79α, S100, myeloperoxidase, Cyclin D1). Results. We can state that stromal-parenchymal structure is typical for the bone marrow of rats as for any other organ. The stromal component is presented with bone tissue (48.8±3.3% at epiphyses), the net of blood vessels (18.7±2.1%), fat tissue (11±2%), fibrous tissue (0.7±0.2%) and the network of reticular fibers. Hematopoietic tissue covers 20.9±3.7% at the femoral epiphyses and 69.6±2.2% at diaphysis. Among these tissues myelopoiesis occupies 74.2±4.7%, erythropoiesis – 24.3±4.7% and lymphopoiesis – less than 5%. Megalokaryocytes take 0.1-0.3%. Conclusion. Considering the lack of significant anatomical, morphological and histological differences of red bone marrow of rats and humans, we can state that hematopoiesis in rats takes place on the basis of the same principles as in humans, although it has certain mechanisms.
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