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Title Immunohistochemical characteristics of aortic valve in the case of atherocalcinosis
Authors Romaniuk, Anatolii Mykolaiovych  
Moskalenko, Roman Andriiovych  
Zakorko, Inna-Marharyta Serhiivna
Lyndin, Mykola Serhiiovych  
Piddubnyi, Artem Mykhailovych  
Lyndina, Yuliia Mykolaivna
Романюк, Софія Анатоліївна
Романюк, София Анатолиевна
Romaniuk, Sofia Anatoliyivna
Yashchishyn, Ihor Oleksandrovych  
Keywords аортальний клапан
аортальный клапан
aortic valve
Type Conference Papers
Date of Issue 2017
Publisher Springer
Citation Immunohistochemical characteristics of aortic valve in the case of atherocalcinosis / A. Romaniuk, R. Moskalenko, I.-M. Zakorko [et al.] // Virchows Arch. - 2017. - Vol. 471, Suppl. 1. – S. 188.
Abstract Objective: According to the results of the Euro-Heart Survey on Vascular Heart Disease the most common pathology is nonrheumatic aortic steno­sis, it is also called as calcific aortic valve stenosis (CAVS), as in its pathogenesis the process of biomineralization of valve cusps and ring plays the main role Method: 30 samples of mineralized aortic valves (I group) and 10 sam­ples of aortic valve without evidence of biomineralization (II group - control) were studied. Immunohistochemical study of expression of col­lagen I, CD68, MPO, S100A9), caspase3 andosteopontin was conducted in AV tissue of both groups. Results: In CAV tissues the fibrillar component (collagen I) growths was found, but the quantitative compositions of circulating inflammatory cells (CD68+) are not significantly different from the control group. CAVs contain much more MPO+ -cells (p< 0.001) in comparison to the group of AV without biomineralization. Our data show a significant increase of the S100A9 and OPN expression in the mineralized tissue of AVs (p < 0.01). Also a higher expression level of Casp3 and MPO was found in CAVs (p< 0.05). Conclusion: High Casp 3 expression confirms the increased level o f cell elimination in the CAVs tissue, which is obviously connected with the impact of high local concentrations ofS100A9. These facts can contribute to the development of pathological biomineralization o f AV. Since osteopontin inhibits the hydroxyapatite formation by binding to the surface of the crystals, its hyperproduction is a counteracting factor against biomin­eralization in AV tissue.
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