The effect of prostatic stones on the immunophenotype of prostate cancer cells

Piddubnyi, Artem Mykhailovych; Lyndin, Mykola Serhiiovych; Moskalenko, Yuliia Vasylivna; Vynnychenko, Ihor Oleksandrovych; Romaniuk, Anatolii Mykolaiovych; Moskalenko, Roman Andriiovych

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Title	The effect of prostatic stones on the immunophenotype of prostate cancer cells
Authors	Piddubnyi, Artem Mykhailovych Lyndin, Mykola Serhiiovych Moskalenko, Yuliia Vasylivna Vynnychenko, Ihor Oleksandrovych Romaniuk, Anatolii Mykolaiovych Moskalenko, Roman Andriiovych
ORCID	http://orcid.org/0000-0002-6508-0131 http://orcid.org/0000-0003-4385-3903 http://orcid.org/0000-0002-5398-0298 http://orcid.org/0000-0002-2339-6509 http://orcid.org/0000-0003-2560-1382 http://orcid.org/0000-0002-2342-0337
Keywords	рак простати рак простаты prostate cancer простатоліти простатолиты prostatic stones метастаз metastasis остеобластичний фенотип остеобластический фенотип osteoblastic phenotype
Type	Conference Papers
Date of Issue	2019
URI	http://essuir.sumdu.edu.ua/handle/123456789/73112
Publisher	Lithuanian University of Health Sciences
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Citation	The effect of prostatic stones on the immunophenotype of prostate cancer cells / A. Piddubnyi, M. Lyndin, Y. Moskalenko [et al.] // Medicina: 77th International Scientific Conference of the University of Latvia (February 22, 2019 Riga, Latvia). - 2019. - Vol. 55. - Supplement 1. - P. 95.
Abstract	Background.Prostate cancer (PGC) is leading the way in the structure of cancer morbidity around the world. The presence of prostatic concretions (PC) and skeletal metastases significantly reduces the patients’ life quality and worsens the prognosis of the disease. However, the phenomenon of osteotropic tumor metastases is not sufficiently studied. Aim.To define the impact of PC on the development of prostate cancer metastasis to the bones. Methods.10 samples of PGC with PC, 10 intact PGC specimens, and PGC metastasis tissue to lymph node were analysed. Histology (staining with hematoxylin-eosin), histochemistry (von Kossa reaction, alizarin red), immunohistochemistry (OSN, Col I, Col II, Bax, Casp3, MPO, CD68), SEM, EDS. Results.All PC samples had the calcium hydroxyapatite origin with a slight deviation from the stoichiometric composition and admixture of extraneous elements. Assessment of apoptotic potential (Вах and Саsp3) and inflammatory infiltration (MPO and CD68) revealed the significantly higher rates of these processes in PGC tissue with PC (p <0.01). We suggest that the combined effect of these factors predetermines the development of a specific phenotype of cancer cells. This phenomena is manifested by the significantly higher OSN and Col I osteoblastic markers expression in PGC with PC and metastatic tissue (p <0.05). Conclusions.The determination of osteoblastic markers expression in PGC can be used as criterion for evaluation of probability of bone metastases development. The presence of PC in PGC tissue can be an important prognostic information for clinicians.The presence of these pathological inclusions, namely the PC, promotes the expression of osteoblastic markers in PGC tissue, which helps the tumor cells to recognize a favorable microenvironment. Acknowlegments.This research has been performed with the financial support of grants of the Ministry of Education and Science of Ukraine No. 0117U003937 “The development of tumor diagnosis method of reproductive system organs using cellular adhesion molecules of cancerembryonic antigen” and No. 0118U003570 “The efficiency of “liquid biopsy” and tissue biopsy in the diagnosis and treatment of malignant tumors”.
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