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Title Serous Adenocarcinoma of Fallopian Tubes: Histological and Immunohistochemical Aspects
Authors Hyriavenko, Nataliia Ivanivna  
Lyndin, Mykola Serhiiovych  
Sikora, Kateryna Oleksiivna  
Piddubnyi, Artem Mykhailovych  
Karpenko, Liudmyla Ivanivna  
Гирявенко, Дмитрій Романович
Гирявенко, Дмитрий Романович
Hyriavenko, D.R.
Diachenko, Olena Olehivna
Sikora, Vladyslav Volodymyrovych  
Romaniuk, Anatolii Mykolaiovych  
ORCID http://orcid.org/0000-0002-9805-014X
http://orcid.org/0000-0003-4385-3903
http://orcid.org/0000-0002-9814-6512
http://orcid.org/0000-0002-6508-0131
http://orcid.org/0000-0002-5274-7021
http://orcid.org/0000-0002-4147-6879
http://orcid.org/0000-0003-2560-1382
Keywords серозна карцинома
серозная карцинома
serous carcinoma
пухлина
опухоль
neoplasm
фалопієві труби
фаллопиевы трубы
fallopian tubes
рецептори до естрогену
рецепторы к эстрогену
estrogen receptors
рецептори до прогестерону
рецепторы к прогестерону
progesteron receptors
Ki-67
HER2/new
p53
Bcl-2
судинний фактор росту
сосудистый фактор роста
vascular endothelial growth factor
Type Article
Date of Issue 2019
URI http://essuir.sumdu.edu.ua/handle/123456789/74907
Publisher The Korean Society of Pathologists;The Korean Society for Cytopathology
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Citation Serous Adenocarcinoma of Fallopian Tubes: Histological and Immunohistochemical Aspects / N. Hyriavenko, М. Lуndіn, K. Sikora [et al.] // Journal of Pathology and Translational Medicine. – 2019. – Vol. 53(4). – P. 236-243. – https://doi.org/10.4132/jptm.2019.03.21.
Abstract Background: Although primary cancer of the fallopian tubes is a relatively rare type of tumor in female reproductive organs, its mortality is quite high. It is important to identify molecular and biological markers of this malignancy that determine its specific phenotype. Methods: The study was carried out on samples received from 71 female patients with primary cancer of the fallopian tubes. The main molecular and biological properties, including hormone status (estrogen receptor [ER], progesterone receptor [PR]), human epidermal growth factor receptor (HER2)/neu expression, proliferative potential (Ki-67), apoptosis (p53, Bcl-2), and pro-angiogenic (vascular endothelial growth factor) quality of serous tumors were studied in comparison with clinical and morphological characteristics. Results: ER and PR expression is accompanied by low grade neoplasia, early clinical disease stage, and absence of lymphogenic metastasis (p < .001). HER2/neu expression is not typical for primary cancer of the fallopian tubes. Ki-67 expression is characterized by an inverse correlation with ER and PR (p < .05) and is associated with lymphogenic metastasis (p < .01). p53+ status correlates with high grade malignancy, tumor progression, metastasis, negative ER/PR (p < .001), and negative Bcl-2 status (p < .05). Positive Bcl-2 status is positively correlated with ER and PR expression and low grade malignancy. Conclusions: Complex morphologic (histological and immunohistochemical) study of postoperative material allows estimation of the degree of malignancy and tumor spread to enable appropriate treatment for each case.
Appears in Collections: Наукові видання (НН МІ)

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Lithuania Lithuania
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Ukraine Ukraine
12243913
United Kingdom United Kingdom
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United States United States
22963605
Unknown Country Unknown Country
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