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Title Prostate cancer leads to a change in the composition of tissue carbohydrates
Authors Romaniuk, Anatolii Mykolaiovych  
Piddubnyi, Artem Mykhailovych  
Lyndin, Mykola Serhiiovych  
Sikora, Vladyslav Volodymyrovych  
Hyriavenko, Nataliia Ivanivna  
Moskalenko, Roman Andriiovych  
ORCID http://orcid.org/0000-0003-2560-1382
http://orcid.org/0000-0002-6508-0131
http://orcid.org/0000-0003-4385-3903
http://orcid.org/0000-0002-4147-6879
http://orcid.org/0000-0002-9805-014X
http://orcid.org/0000-0002-2342-0337
Keywords рак передміхурової залози
рак предстательной железы
prostate cancer
вуглеводи
углеводы
carbohydrates
PAS
гістохімія
гистохимия
histochemistry
Type Conference Papers
Date of Issue 2019
URI http://essuir.sumdu.edu.ua/handle/123456789/75111
Publisher Springer
License
Citation Prostate cancer leads to a change in the composition of tissue carbohydrates / A. Romaniuk, A. Piddubnyi, M. Lyndin et al. // Virchows Archiv. European Journal of Pathology. – 2019. – Vol. 475, Suppl 1. – S. 25. – Pathology: Path to Precision medicine : 31th European Congress of Pathology, 7–11 September 2019, Nice, France.
Abstract The objective of the investigation is following - to study the changes in the composition of the carbohydrate components of prostate cancer tissue (PCa). Methods: 60 PCa samples (30 samples of PCa with intraluminal inclusions (prostatic calculi and corpora amylacea) and 30 without them) were used for study. 20 samples of benign prostatic hyperplasia tissue were used as control. All samples were examined by hematoxylin-eosin staining and by histochemistry (PAS reaction, alcian blue staining at pH 2.5). Results: Positive PAS staining was found both in the tissue of the prostate gland and in the secret. Strongest intensity of the signal was found in glands filled by secret. Corpora amylacea and the secret of the PCa glands were PAS-negative. BPH tissue had a weak alcian blue staining intensity. The secret of PCa glands was very positive for alcian blue staining. We indicate the presence of higher amount of acid mucopolysaccharides in the connective tissue component of PCa. Conclusion: Changes in the carbohydrate composition of the prostate tissue during carcinogenesis were found. It manifests in reduced amount of glycosaminoglycans and increased amount of acid mucopolysaccharides in both the secret of the glands and the tumour tissue.
Appears in Collections: Наукові видання (НН МІ)

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