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Title Pathogenesis of Warthin’s tumors
Authors Kuzenko, Yevhen Viktorovych  
Romaniuk, Anatolii Mykolaiovych  
Diachenko, O.O.
Hudymenko, Olena Oleksandrivna
ORCID http://orcid.org/0000-0003-3985-8912
http://orcid.org/0000-0003-2560-1382
Keywords слинної залози
слюнной железы
salivary gland
аденома
adenoma
лімфома
lymphoma
пухлина Вартіна
Warthin’s tumor
кістозна папілярна аденома
cystic papillary adenoma
Type Article
Date of Issue 2016
URI http://essuir.sumdu.edu.ua/handle/123456789/75120
Publisher Akademiai Kiado
License
Citation Pathogenesis of Warthin’s tumors / Y.V. Kuzenko, A.M. Romanuk, O.O Dyachenko et al. // Interventional Medicine & Applied Science. – 2016. – №8(2). – С. 41–48.
Abstract Warthin’s tumor, also known as papillary cystadenoma lymphomatosum, monomorphic adenoma, or adenolymphoma, is a benign cystic tumor of the salivary glands containing abundant lymphocytes and lymph node-like stroma. It is named after the pathologist Aldred Scott Warthin, who described two cases in 1929. Objective: The aim of this study is to analyze the pathogenesis of Warthin’s tumor. Methods: A total of 15 patients with Warthin’s tumor were studied. Hematoxylin and eosin stains, which have been used for at least a century and are still essential for recognizing various tissue types and the morphologic changes for cancer diagnosis, were used. Warthin’s tumor was evaluated for the expression of MGMT, CD3, HSP90AA1, MMP-1, Bcl-2, CD79A, IgG, Ki-67, p53, IgM, OPN, S100, myeloperoxidase, and VEGF by immunohistochemistry. Results: Immunohistochemical staining confirmed that the immune cells within the follicles of Warthin’s tumor were positive for MGMT (10.0±0.34%), Ki-67 (13.3±0.45%), Bcl-2 (42.6±8.33), and p53 (11.6±2.3). The immune cells associated with CD3 were present at the stroma of residual cells (47.3±3.89); however, they were not present in the epithelium cell layers. B cells (CD79A) consistent with germinal centers were present within the immune cells and formed follicles (43.2 ± 13.5%). Conclusions: Histopathological analysis of the stroma and parenchyma revealed balanced distribution of epithelial and stromal component. Epithelial component of the Warthin’s tumor is the trigger for the tumor process. This study indicates that the Warthin tumor is a consequence of inflammatory etiology.
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