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Title Optimization of the treatment of rotavirus infection in children by using bacillus clausii
Authors Smiian, Oleksandr Ivanovych  
Smiian-Horbunova, Kateryna Oleksandrivna
Bynda, Tetiana Parfeniivna
Loboda, Andrii Mykolaiovych  
Popov, Serhii Vitaliiovych
Vysotskyi, Ihor Yuriiovych  
Moshchych, O.P.
Vasylieva, Olena Hennadiivna
Manko, Y.A.
Ovsianko, Olena Leonidivna
Kolesnikova, Mariia Viktorivna
Dolgova, Nataliia Oleksandrivna
Aleksakhina, Tetiana Oleksiivna
Al-Rawashdeh, Bara
Keywords ротавірус
rotavirus
гуморальний імунітет
гуморальный иммунитет
humoral immunity
діти
дети
children
IgA
sIgA
IgM
IgG
Type Article
Date of Issue 2019
URI http://essuir.sumdu.edu.ua/handle/123456789/75464
Publisher Aluna Publishing
License
Citation Optimization of the treatment of rotavirus infection in children by using bacillus clausii / O.I. Smiian, K.O. Smiian-Horbunova, T.P. Bynda et al. // Wiadomosci Lekarskie. - 2019. - T. 72, №7. - P. 1320-1323.
Abstract Rotavirus infection is a leading place in the structure of acute intestinal infections in children. Rotavirus is excreted in 4 0-60 % of children hospitalized with gastroenteritis all over the world. Every year, 2 million patients are hospitalized with a severe form of RVI, 25 million need medical help from a doctor and 111 million cases are treated at home. The purpose of our study was to optimize the treatment of rotavirus infection in children by using Bacillus clausii. There were 65 children with a rotavirus infection under supervision. The control group was consisted of 28 practically healthy children. The study of humoral immunity was carried out on the basis of determining the serum content of immunoglobulin G, immunoglobulin M, immunoglobulin A, and secretory immunoglobulin A in coprofiltrate. In the process of treatment, the children were divided into two groups: the first received standard treatment, the second group were added to standard treatment with a probiotic drug (Bacillus clausii). In children with RVI with modified treatment main symptoms were reduced compared with the children receiving standard treatment, (p <0.001). In patients with rotavirus infection in the acute period of the disease, a decrease in the concentration of IgA (p < 0.001) and an increase in IgM (p < 0.001) in serum and a decrease in sIgA (p < 0.001) in coprofiltrate was observed in comparison with children in control group. In the period of reconvalescence in children after the traditional treatment, it wasn't revealed normalization of the immunoglobulins. Patients receiving a probiotic drug in addition to traditional treatment it was revealed normalization of the parameters of serum immunoglobulins A, M, G and sIgA in coprofiltrate. So, the probiotic drug containing Bacillus clausii has a positive effect on the humoral immune system in children with rotavirus infection.
Appears in Collections: Наукові видання (МІ)

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