Changes of immunoregulatory index among young children suffering from rotavirus intestinal infection

Abstract

Rotavirus infection occupies an important place in the structure of infectious diseases and is the main reason of morbidity and mortality in young children. According to WHO experts, almost every child suffers from rotavirus gastroenteritis during the first five years of life, regardless of social and economic status and place of residence. Children under the age from 6 to 24 months suffer from rotavirus infection the most often. According to WHO, the incidence in different countries ranges from 250 to 3,000 per 100,000 children. More than 111 million cases of rotavirus gastroenteritis are diagnosed every year. The course of the disease mostly depends on the immune system of the patient. A special place here belongs to the cell role, namely the immunoregulatory index, which is the ratio of CD4 + to CD8 + T-lymphocytes and is an indicator of body's defense system against infections.