Наукові видання (НН МІ)
Permanent URI for this collectionhttps://devessuir.sumdu.edu.ua/handle/123456789/132
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Item Invasive Breast Carcinoma of No Special Type with Medullary Pattern: Morphological and Immunohistochemical Features(Turkish Journal of Pathology, 2022) Линдін, Микола Сергійович; Lyndin, Mykola Serhiiovych; Гирявенко, Наталія Іванівна; Hyriavenko, Nataliia Ivanivna; Сікора, Владислав Володимирович; Sikora, Vladyslav Volodymyrovych; Линдіна, Юлія Миколаївна; Lyndina, Yuliia Mykolaivna; Soroka, Y.; Романюк, Анатолій Миколайович; Romaniuk, Anatolii MykolaiovychObjective: Our study investigated the morphological and immunohistochemical characteristics of invasive breast carcinoma of no special type (IBC-NST) with medullary pattern to explore the inconsistencies between the structural and clinical traits of this category of tumor. Material and Method: The breast carcinoma samples (n = 26) with medullary pattern (defined according to established criteria) were subjected to immunohistochemical assays of the following receptors: ER, PR, HER2/neu, Ki-67, p53, Bcl-2, VEGF, MMP1, E-cadherin, EGFR, Hsp70, Hsp90, CD20, CD3, CD4, CD8, CD68, CD163, CD56, CD138, MPO, S100, IgG, IgM, and PD-L1. Results: IBC-NST with medullary pattern was found to have negative expression of ER, PR, and HER2/neu; strong positive expression of Kі-67, mutant р53, Bcl-2, E-cadherin, EGFR, and PD-L1; moderate positive expression of Hsp70 and Hsp90; and low or negative expression of VEGF and MMP1. Furthermore, there was pronounced variability in the qualitative composition of tumor immune infiltrates with regards to T-lymphocytes, B-lymphocytes, macrophages, plasmocytes, and granulocytes. Conclusion: IBC-NST with medullary pattern has many unfavourable morphological and immunohistochemical prognostic characteristics, which are balanced against the pronounced protective properties of the tumor cells and the qualitative characteristics of the tumor microenvironment. These can lead to a favourable disease course despite the relatively adverse features of the carcinoma cells.Item Morphological Peculiarities of Parasitic (Trichosomoides crassicauda) Infection in Rat Urinary Bladder(Sciendo, 2021) Сікора, Владислав Володимирович; Сикора, Владислав Владимирович; Sikora, Vladyslav Volodymyrovych; Линдін, Микола Сергійович; Лындин, Николай Сергеевич; Lyndin, Mykola Serhiiovych; Гирявенко, Наталія Іванівна; Гирявенко, Наталья Ивановна; Hyriavenko, Nataliia Ivanivna; Москаленко, Роман Андрійович; Москаленко, Роман Андреевич; Moskalenko, Roman Andriiovych; Линдіна, Юлія Миколаївна; Лындина, Юлия Николаевна; Lyndina, Yuliia Mykolaivna; Сікора, Катерина Олексіївна; Сикора, Екатерина Алексеевна; Sikora, Kateryna Oleksiivna; Чижма, Руслана Анатоліївна; Чижма, Руслана Анатольевна; Chyzhma, Ruslana Anatoliivna; Дяченко, Олена Олегівна; Дяченко, Елена Олеговна; Diachenko, Olena Olehivna; Романюк, Анатолій Миколайович; Романюк, Анатолий Николаевич; Romaniuk, Anatolii MykolaiovychTrichosomoides crassicauda (T. crassicauda) is a parasite commonly localized in the urinary bladder (UB) of laboratory and wild rats. The presence of these helminths can influence the prediction of pathological changes in the UB. Therefore, the purpose of this research was to make a comprehensive study of the features of the morphological changes in the UB wall of white laboratory rats as a result of T. crassicauda infestation. The study was performed on male rats using histological (Hematoxyline-Eosin and Alcian Blue staining) and immunohistochemical (Ki-67, Hsp70, Hsp90α, CD3 and CD20) methods. T. crassicauda was detected in both urine and UB samples. Morphological changes were observed as disruption in urothelial cell stratification and insignificant proliferative and immune responses in the UB. Increased heat shock protein levels were observed which may suggest a natural body’s resistance to this parasite.Item Effect of heavy metals on microstructural and microelemental changes in the rats urinary bladder(Springer, 2020) Сікора, Владислав Володимирович; Сикора, Владислав Владимирович; Sikora, Vladyslav Volodymyrovych; Линдін, Микола Сергійович; Лындин, Николай Сергеевич; Lyndin, Mykola Serhiiovych; Гирявенко, Наталія Іванівна; Гирявенко, Наталья Ивановна; Hyriavenko, Nataliia Ivanivna; Линдіна, Юлія Миколаївна; Лындина, Юлия Николаевна; Lyndina, Yuliia Mykolaivna; Москаленко, Роман Андрійович; Москаленко, Роман Андреевич; Moskalenko, Roman Andriiovych; Піддубний, Артем Михайлович; Поддубный, Артем Михайлович; Piddubnyi, Artem Mykhailovych; Сікора, Катерина Олексіївна; Сикора, Екатерина Алексеевна; Sikora, Kateryna Oleksiivna; Kuts, V.Global environmental pollution leads to the distribution of heavy metal salts (HMS) in the ecosystem and their impact on the organism. To study the influence of the heavy metals (HM) accumulation on the ultrastructural changes in rat’s urinary bladder (UB).Item The study of the toxic effect of the heavy metals salts on the erythropoiesis in the rats(Springer, 2020) Линдіна, Юлія Миколаївна; Лындина, Юлия Николаевна; Lyndina, Yuliia Mykolaivna; Сікора, Владислав Володимирович; Сикора, Владислав Владимирович; Sikora, Vladyslav Volodymyrovych; Линдін, Микола Сергійович; Лындин, Николай Сергеевич; Lyndin, Mykola Serhiiovych; Soroka, Y.; Romaniuk, S.; Карпенко, Людмила Іванівна; Карпенко, Людмила Ивановна; Karpenko, Liudmyla Ivanivna; Романюк, Анатолій Миколайович; Романюк, Анатолий Николаевич; Romaniuk, Anatolii MykolaiovychHeavy metals salts (HMS) are the most common pollutants that are proved to have the negative effect. The objective is to determine the morphological features of the marrow in rats, caused by the combined effect of the heavy metals salts.