Наукові видання (НН МІ)
Permanent URI for this collectionhttps://devessuir.sumdu.edu.ua/handle/123456789/132
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Item Neurological disorders in pregnant women in low- and middle-income countries - Management gaps, impacts, and future prospects: A review perspective(SAGE Journals, 2023) Debrah, A.F.; Adebusoye, F.T.; Shah, M.H.; Awuah, W.A.; Tenkorang, P.O.; Bharadwaj, H.R.; Wellington, J.; Ghosh, S.; Abiy, L.; Fernandes, C.; Abdul-Rahman, Т.; Личко, Володимир Станіславович; Lychko, Volodymyr Stanislavovych; Бабар, Тетяна Володимирівна; Babar, Tetiana Volodymyrivna; Нікітіна, Ірина Миколаївна; Nikitina, Iryna MykolaivnaNeurological disorders during pregnancy are a substantial threat to women’s health, particularly in low- and middleincome countries. Furthermore, a critical shortage of mental health workers and neurologists exacerbates the already pressing issue, where a lack of coordination of respective healthcare among multidisciplinary teams involved in managing these conditions perpetuates the current state of affairs. Financial restrictions and societal stigmas associated with neurological disorders in pregnancy amplify the situation. Addressing these difficulties would necessitate a multifaceted approach comprising investments in healthcare infrastructure, healthcare professional education and training, increased government support for research, and the implementation of innovative care models. Improving access to specialized treatment and coordinated management of antenatal neurological diseases will precipitate improved health outcomes for women and their families in low- and middle-income countries.Item Pathogenetic aspects of metabolic syndrome in experimental animals(Aluna Publishing, 2022) Dziubanovskyi, I.Y.; Prodan, A.M.; Pidruchna, S.R.; Melnyk, N.A.; Dzhyvak, V.G.; Нікітіна, Ірина Миколаївна; Никитина, Ирина Николаевна; Nikitina, Iryna MykolaivnaThe aim: Was to study the state of the nitric oxide system, LPO and antioxidant system in the body of experimental animals in simulated metabolic syndrome. The aim of the study was to study the state of the nitric oxide system, lipid peroxidation and antioxidant system in the body of experimental animals in simulated MS. Materials andmethods: The study was performed on 20 white male Wistar rats. Male control rats (n = 10) were fed a normal control diet. Male rats of the main group (n = 10) were fed a diet high in fat (over 60 % energy from fats) for 16 weeks, thus modeling the development of MS. The indicators of the prooxidant and antioxidant system, as well as the nitric oxide system were determined by photospectrographic method. Results: In animals with simulated MS, intensification of lipoperoxidation (statistically significantly higher level of TBA-active products 1.84 times), depletion of antioxidant protection (statistically significantly lower level of superoxide dismutase 2 times), activation of nitric oxide system (statistically significantly higher NO-synthase level 2.15 times) were found compared with intact animals. Conclusions: In animals with simulated MS, activation of lipid peroxidation processes, depletion of antioxidant protection and increased levels of nitrooxidative stress were found.