Наукові видання (НН МІ)
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Item The role of heavy metal salts in pathological biomineralization of breast cancer tissue(Wroclaw Medical University, 2016) Романюк, Анатолій Миколайович; Романюк, Анатолий Николаевич; Romaniuk, Anatolii Mykolaiovych; Линдін, Микола Сергійович; Лындин, Николай Сергеевич; Lyndin, Mykola Serhiiovych; Москаленко, Роман Андрійович; Москаленко, Роман Андреевич; Moskalenko, Roman Andriiovych; Гортинська, Олена Миколаївна; Гортинская, Елена Николаевна; Hortynska, Olena Mykolaivna; Линдіна, Юлія Миколаївна; Лындина, Юлия Николаевна; Lyndina, Yuliia MykolaivnaBackground. The process of pathological biomineralization plays an important part in the morphogenesis of tumors. The role of heavy metal salts in the pathological mineralization of breast cancer tissue should not be ruled out, considering their ability to enter into covalent bonds with calcium salt molecules. Objectives. The aim of the study was to investigate the microelement composition of breast cancer calcifications and the participation of heavy metals in their formation process. Material and Methods. The material for the study consisted of 20 specimens of breast cancer tissue in which calcifications had been found in histological tests (hematoxylin-eozin and alizarin red S staining). The chemical composition of the calcifications was studied using a scanning electron microscope with an energy-dispersive spectrometer. Results. Alizarin red S staining detected the presence of concrements in tumor tissue and rings of calcification around these deposits. Examining the biomineralization with energy dispersive spectrometry showed that along with calcium and phosphorus, it contained microelements such as iron, zinc, copper, chromium and nickel, which can replace calcium ions in the exterior part of hydroxyapatite molecules. This causes the hydroxyapatite molecule’s molar mass to increase and its solubility to decrease; its chances of being deposited in tumor tissue also increase. This implies that an increased intake of heavy metal salts in organisms can lead to pathological mineralization of breast cancer tissue. Conclusions. Excessive intake of heavy metal salts into the body leads to their involvement in the pathological mineralization of breast cancer tissue. This happens due to these salts bonding to hydroxyapatite molecules, direct sedimentation of proteins and increasing degenerative-necrotic changes in breast cancer tissue as the mineralization process progresses.Item The effect of heavy metals accumulation on morphological and immunohistochemical features of breast cancer(Springer, 2016) Линдін, Микола Сергійович; Лындин, Николай Сергеевич; Lyndin, Mykola Serhiiovych; Романюк, Анатолій Миколайович; Романюк, Анатолий Николаевич; Romaniuk, Anatolii Mykolaiovych; Москаленко, Роман Андрійович; Москаленко, Роман Андреевич; Moskalenko, Roman AndriiovychObjective: The chemical composition determination of neoplastic breast :issue, study of prognostic-important receptors expression in the breast cancer cells, establishing linkages between all the derived indicators.Item Chemical composistion changes of immature rats testis under increased receipts of heavy metals salts(Pavol Jozef Šafбrik University in Košice, Faculty of Medicine, 2014) Москаленко, Юлія Василівна; Москаленко, Юлия Васильевна; Moskalenko, Yuliia Vasylivna; Рєзнік, Андрій Васильович; Резник, Андрей Васильевич; Rieznik, Andrii Vasylovych; Рєзнік, Марія Андріївна; Резник, Мария Андреевна; Rieznik, Mariia Andriyivna; Москаленко, Роман Андрійович; Москаленко, Роман Андреевич; Moskalenko, Roman AndriiovychIntroduction: One reason for the prevalence of infertility in men is high sensitivity of the male reproductive system to adverse exogenous and endogenous factors in the prenatal and early postnatal periods. One of the most common and dangerous pollutants for the reproductive system is the heavy metals compounds (HMC), which have both direct and indirect effects on the development of reproductive system. Aim: To investigate the intensity of accumulation of zinc, copper, lead, manganese, chromium and iron in tissues and structures of immature rat testes under their alimentary intake and under conditions of L-carnitine correction. Material and Methods: The survey was conducted on 128 white lab immature male rats.The tissue of testes was studied by methods of histology, scanning electron microscopy, atomic absorption spectroscopy (AAS) Results: Using spectrophotometry in atomic absorption mode, it is found out that the level of zinc is reduced, and the content of other analyzed trace elements increases. Accumulation of copper, iron, manganese, chromium and lead in testes tissue is mostly expressed in the period of 60 days; iron, lead and chromium show the largest organ tropism. The low rate of HMC accumulation in the testes of rats of breast and suckling age period is explained by the limited intake of xenobiotics via maternal milk. Loss of zinc by testis tissue is caused by antagonistic interactions between chemical elements that come into the body of rats in excessive quantities. Interaction of chemical elements at different levels can lead to secondary violations of chemical and structural homeostasis of the organ, causing further inhibition of its function. Conclusion: The results of chemical analysis of immature animals’ testes, obtained by SEM, indicate the dependence of accumulation of microelements of heavy metals from the morphofunctional activity of the histological structure of the studied organ. Heavy metals mainly accumulate in a functionally active spermatogenic epithelium.Item Морфологічні та біохімічні особливості раку молочної залози в умовах забруднення довкілля солями важких металів(ВДНЗ "УМСА", 2014) Романюк, Анатолій Миколайович; Романюк, Анатолий Николаевич; Romaniuk, Anatolii Mykolaiovych; Линдін, Микола Сергійович; Лындин, Николай Сергеевич; Lyndin, Mykola Serhiiovych; Москаленко, Роман Андрійович; Москаленко, Роман Андреевич; Moskalenko, Roman Andriiovych; Кузенко, Євген Вікторович; Кузенко, Евгений Викторович; Kuzenko, Yevhen ViktorovychМетою дослідження стало вивчення хімічного складу тканини раку молочної залози. Проводилося визначення важких металів у пухлинній тканині за допомогою атомної абсорбції та енерго-дисперсійною спектрометрії. Встановлено взаємозв’язок між надмірним надходження сполук важких металів в організм людини та накопичення їх у пухлинній тканині молочної залози, що може виступати пусковим фактором канцерогенезу. При цитуванні документа, використовуйте посилання http://essuir.sumdu.edu.ua/handle/123456789/37095