Specific Interactions and Crystallization of Drug-Loaded Micelles in the System: Prednisolon/PAAm-b-PEO-b-PAAm Micellar Solutions

Zheltonozhskaya, T.B.; Partsevskaya, S.V.; Klymchuk, D.O.; Gorchev, V.F.

Please use this identifier to cite or link to this item: http://essuir.sumdu.edu.ua/handle/123456789/35235

Or use following links to share this resource in social networks: Recommend this item

Title	Specific Interactions and Crystallization of Drug-Loaded Micelles in the System: Prednisolon/PAAm-b-PEO-b-PAAm Micellar Solutions
Authors	Zheltonozhskaya, T.B. Partsevskaya, S.V. Klymchuk, D.O. Gorchev, V.F.
ORCID
Keywords	Triblock copolymer Intramolecular polycomplex Micelles Prednisolone Encapsulation
Type	Conference Papers
Date of Issue	2013
URI	http://essuir.sumdu.edu.ua/handle/123456789/35235
Publisher	Sumy State University
License
Citation	Specific Interactions and Crystallization of Drug-Loaded Micelles in the System: Prednisolon/PAAm-b-PEO-b-PAAm Micellar Solutions [Текст] / T.B. Zheltonozhskaya, S.V. Partsevskaya, D.O. Klymchuk, V.F. Gorchev // Nanomaterials: Applications & Properties (NAP-2013) : 3-rd International conference, Alushta, the Crimea, Ukraine, September 16-21, 2013 / Edited by: A. Pogrebnjak. - Sumy : Sumy State University, 2013. - V.2, No2. - 02PCN33
Abstract	Encapsulaton of poorly soluble crystallizing drug prednisolone (PS) in micellar solutions of PAAm-b- PEO-b-PAAm triblock copolymer (TBC) based on chemically complementary poly(ethylene oxide) and polyacrylamide (MnPEO = 6 kDa, MnPAAm = 116 kDa) was studied by dynamic light scattering and transmission electron microscopy. The equilibrium mechanism of the encapsulation process and the effect of specific aggregation of PS-loaded micelles by their “coronas” that promoted the drug crystallization were established. The question about the presence of TBC micelles inside crystalline space was discussed. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/35235
Appears in Collections:	Наукові видання (ЕлІТ)