Preparation and Medico-Biological Tests Nanocolloids Radiopharmaceuticals on the Based of Modified DTPA Labeled Technetium-99m

Abstract

Technetium-99m recovery process in the presence of stannous Sn (II) with the aim to determine it is necessary and sufficient quantity, that would provide a complete "recovery" of 99mTc in the reaction mixture has been investigated. The studies were identified conditions for receiving radioactive nanopreparations based on a modified molecule DTPA. The authors has been shown that the direct interaction of 99mTc eluate solution with a solution of a mixture of SnCl2 DTPAmod and radiochemical impurity content unreduced 99mTc (VII) in the preparation labeled with nanocolloids is 2,7% and the yield nanocolloids with the size of 100 nm is about 80%. The medical-biological testing of the agents 99mTc (IV) - DTPAmod on test animals for the determination of the functional suitability for the scintigraphic imaging of lymph nodes has been carried out. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/35405