Ultrasonic Nanomedicine in the Therapy of Oncological Diseases

Abstract

In this paper the authors develop the concept of using solid-phase nanoscale inclusions in biological structures, as the concentrators of acoustic energy for ultrasound therapy of oncological diseases. Particu-lar attention is paid to possibility of synthesis of these inclusions directly in the tumor tissue. The validity of the hypothesis of solid-phase sonosensitization has been confirmed in vitro on bacterial cultures. Super-additive effect of combined action of ultrasound and solid-phase sonosensitizer on bacterial cultures was shown. Experimental studies on animals showed that the ultrasound exposure of malignant tumors con-taining nanoparticles of gold and some complex compounds (e.g. theraphthal) results in a significant ther-apeutic effect, which is expressed in a considerable inhibition of tumor growth. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/35412