The Effects of Chronic Intake of Cerium Dioxide or Gadolinium Ortovanadate Nanoparticles in Aging Male Rats

Abstract

The acquisition of new nanomaterials with unique properties for biomedical application is an essential requirement now days. It is important and necessary to evaluate the safety and the delayed consequences of nanoparticles entry for living organisms. The aim of the present work was to investigate the effects of chronic intake of cerium dioxide and gadolinium ortovanadate nanoparticles of some character in aging male rats. In blind experiment 18 – 20 months age Wistar male rats were fed the colloidal solution (0.5 ml) of the nanoparticles either cerium dioxide or gadolinium ortovanadate (GdVO4:Eu3+) during 70 days. Evolution of emotional state, body mass, glucose homeostasis, level of sex hormone (testosterone and estradiol) has been investigated over a period of experiment. At termination, it was analyzed of spermogram and antioxidant properties of sperm and some tissues. The acute toxicity of nanomaterials were evaluate in outbred mice. No effects of cerium dioxide nanoparticles has been found. GdVO4:Eu3+ male rats demonstrated the decrease in accretion of body weight and glucose level, and the less dejection compared with the untreated aging rats. These rats has increased testosterone level, sperm concentration and reduced chemiluminescence of gametes. The acute toxicity test defined GdVO4 nanoparticles as a nontoxic material – LD50  5 g/kg bm. Positive influence of GdVO4:Eu3+ nanoparticles on metabolic processes, emotional capability and reproductive function of senescent organism could be a basis for formation a new direction of antiaging therapy. When you are citing the document, use the following link http://essuir.sumdu.edu.ua/handle/123456789/35490