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Title The features of morphological changes in the urinary bladder under combined effect of heavy metal salts
Authors Romaniuk, Anatolii Mykolaiovych  
Sikora, Vladyslav Volodymyrovych  
Lyndin, Mykola Serhiiovych  
Smiianov, Vladyslav Anatoliiovych
Sikora, Volodymyr Vitaliiovych
Lyndina, Yuliia Mykolaivna
Piddubnyi, Artem Mykhailovych  
Hyriavenko, Nataliia Ivanivna  
Korobchanska, Anna Borysivna
Keywords солі важких металів
соли тяжелых металлов
heavy metal salts
сечовий міхур
мочевой пузырь
urinary bladder
гістологічні дослідження
гистологические исследования
histological studies
імуногістохімічні дослідження
иммуногистохимические исследования
immunohistochemical studies
Ki-67
Hps90α
зовнішнє середовище
окружающая среда
environment
Type Article
Date of Issue 2017
URI http://essuir.sumdu.edu.ua/handle/123456789/74944
Publisher Interventional Medicine & Applied Science
License
Citation The features of morphological changes in the urinary bladder under combined effect of heavy metal salts / A. Romaniuk, V. Sikora, M. Lyndin et al. // Interventional Medicine & Applied Science. - 2017. - № 9(2). - P. 1-7. DOI:10.1556/1646.9.2017.2.09.
Abstract Abstract: Purpose: This study is aimed to the investigation of the features of morphological changes in the urinary bladder of mature rats. Results: Received results shown that the experimental group of rats that had the intake of heavy metal salts (HMS) mixture during 30 and 90 days were observed histological and immunohistochemical changes in all structures of the urinary bladder. Depending on the period of influence of heavy metal ions on the wall of the organ, the pathological changes developed in cellular layers of the wall can lead to degenerative and later to atrophic and sclerotic changes. Conclusions: This study demonstrates that high concentrations ofHMS can significantly influence the body. The histological and immunohistochemical studies showed that the influence of the HMS combination leads to deep morphological changes in all structures of the urinary bladder. These changes depend on the period of intake of HMS. Analysis of the obtained results demonstrates the dependence of expression of morphological changes in the urinary bladder on the experiment duration. The final result of these changes may lead to the disorders of bladder’s functions.
Appears in Collections: Наукові видання (МІ)

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