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Title The relationship between lipid metabolism and the level of albuminuria with single nucleotide polymorphism - 204a>c [rs 3808607] cyp7a1 gene in patients with type 2 diabetes mellitus and diabetic nephropathy
Authors Demikhova, Nadiia Volodymyrivna  
Cherkashyna, L.
Chernatska, Olha Mykolaivna  
Mazur, T.
Aleksakhina, Tetiana Oleksiivna  
Demikhov, О
Keywords діабет 2-го типу
диабет 2-го типа
type 2 diabetes mellitus
альбумінурія
альбуминурия
albuminuria
діабетична альбумінурія
диабетическая альбуминурия
diabetic nephropathy
СYP7A1
Type Article
Date of Issue 2019
URI https://essuir.sumdu.edu.ua/handle/123456789/77800
Publisher Romanian National University
License Creative Commons Attribution 4.0 International License
Citation The relationship between lipid metabolism and the level of albuminuria with single nucleotide polymorphism - 204a>c [rs 3808607] cyp7a1 gene in patients with type 2 diabetes mellitus and diabetic nephropathy / N.V. Demikhova, L. Cherkashyna, O.M. Chernatska // Romanian Journal of Diabetes Nutrition & Metabolic Diseases. - 2019. - 26(3). - P. 253-261.
Abstract The purpose of our study was to determine the features of diabetic nephropathy, to identify the relationship between the level of albumin excretion, urine and lipid profile, genotype variants of the CYP7A1 gene in people with type 2 diabetes and diabetic nephropathy. Material and methods. Patients were divided into three groups. Normoalbinuria was detected in group I, and II - microalbuminuria, and III - macroalbuminuria. Determination of albumin to creatinine ratio was more accurate, although more expensive method. We examined single nucleotide polymorphism -204A> C [rs 3808607] of the promoter region of the CYP7A1 gene. Results. It was established that homozygotes by the major allele with genotype AA had lower values of albuminuria, atherogenic lipoproteins, total cholesterol, triglycerides and higher levels of anti- atherogenic lipoproteins than patients with AС and СС genotypes. Conclusion. The СС genotype was most unfavorable in the prognostic plan, since homozygotes for this minor allele were characterized by higher values of albuminuria, total cholesterol, triglycerides, and lower values of high-density lipoprotein.
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