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Title The Role of Genetic Polymorphism in the Formation of Arterial Hypertension, Type 2 Diabetes and their Comorbidity
Authors Shalimova, A.
Fadieienko, G.
Kolesnikova, O.
Isayeva, A.
Zlatkina, V.
Nemtsova, V.
Prosolenko, K.
Psarova, Valentyna Hryhorivna  
Kyrichenko, N.
Kochuieva, M.
ORCID http://orcid.org/0000-0001-6890-272X
Keywords генетичний поліморфізм
генетический полиморфизм
Genetic polymorphism
артеріальна гіпертензія
артериальная гипертензия
arterial hypertension
діабет 2 типу
диабет 2 типа
type 2 diabetes
інсулінорезистентність
инсулинорезистентность
insulin resistance
фактори ризику
факторы риска
risk factors
коморбідність
коморбидность
comorbidity
Type Article
Date of Issue 2019
URI https://essuir.sumdu.edu.ua/handle/123456789/79158
Publisher Current Pharmaceutical Design
License
Citation The Role of Genetic Polymorphism in the Formation of Arterial Hypertension, Type 2 Diabetes and their Comorbidity / A. Shalimova, G. Fadieienko, O. Kolesnikova et al. // Current Pharmaceutical Design. – 2019. – Volume 25, Issue 3 – P. 218 - 227.
Abstract Background: Hereditary component plays a significant role in the formation of insulin resistance (IR) - one of the pathogenetic links of arterial hypertension (AH) and type 2 diabetes mellitus (DM2). However, the genetic predisposition to IR can not be realized and does not manifest itself clinically in the absence of appropriate factors of the environment (excessive nutrition, low physical activity, etc.). Objective: The review summarizes the results of studies which describe the contribution of genetic polymorphism to the formation and progression of AH, DM2 and their comorbidity in various populations. Results: In many studies, it has been established that genetic polymorphism of candidate genes is influenced by the formation, course and complication of AH and DM2. According to research data, the modulating effect of polymorphism of some genetic markers of AH and DM2 on metabolism and hemodynamics has been established. The results of numerous studies have shown a higher frequency of occurrence of AH and DM2, as well as their more severe course with adverse genetic polymorphisms. At the same time, the role of genetic polymorphism in the formation of AH and DM2 differs in different populations. Conclusion: Contradictory data on the influence of gene polymorphisms on the formation of AH and DM2 in different populations, as well as a small number of studies on the combined effects of several polymorphisms on the formation of comorbidity, determine the continuation of research in this direction.
Appears in Collections: Наукові видання (НН МІ)

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