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Title PIK3CA-mutant circulating tumor DNA in patients with breast cancer
Other Titles PIK3CА-мутантная циркулирующая опухолевая ДНК у пациентов с раком молочной железы
Authors Vynnychenko, Ihor Oleksandrovych  
Pryvalova, Anastasiia Oleksandrivna  
Vynnychenko, Oleksandr Ihorovych  
Lyndin, Mykola Serhiiovych  
Sikora, Vladyslav Volodymyrovych  
Romaniuk, Anatolii Mykolaiovych  
ORCID http://orcid.org/0000-0002-2339-6509
http://orcid.org/0000-0002-3445-7303
http://orcid.org/0000-0001-5651-0323
http://orcid.org/0000-0003-4385-3903
http://orcid.org/0000-0002-4147-6879
http://orcid.org/0000-0003-2560-1382
Keywords PIK3CА
рак молочної залози
рак молочной железы
breast cancer
циркулююча пухлинна ДНК
циркулирующая опухолевая ДНК
circulating tumor DNA
Type Article
Date of Issue 2020
URI https://essuir.sumdu.edu.ua/handle/123456789/80853
Publisher MD Publishing House
License In Copyright
Citation Vynnychenko IO, Pryvalova AО, Vynnychenko OI, Lуndіn MS, Sikora VV, Romaniuk AM. PIK3CA-mutant circulating tumor DNA in patients with breast cancer. Azerbaijan Medical Journal (АТJ). 2020;3:79-88. DOI: 10.34921/amj.2020.3.010
Abstract During the research using digital PCR method, tissue and plasma samples from patients with locally advanced breast cancer were examined for the presence of somatic mutation of PIK3CA in biopsy material and circulating tumor DNA. The presence of PIK3CA gene mutation was detected in 17.24% (5/29) of patients in both biopsy material and plasma. A research of serial samples of patients' plasma revealed changes in the amount of circulating tumor DNA throughout all stages of treatment, which reflected the dynamics of the tumor process. For PIK3CA-mutant breast cancer, ER-positive and Her2/neu-negative tumor phenotypes are characteristic.
Appears in Collections: Наукові видання (НН МІ)

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Azerbaijan Azerbaijan
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