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Title Improvement of Skeletal Muscle Regeneration by Platelet-Rich Plasma in Rats with Experimental Chronic Hyperglycemia
Authors Raed, Rtail
Maksymova, Olena Serhiivna  
Illiashenko, Viacheslav Yuriiovych  
Hortynska, Olena Mykolaivna  
Korenkov, Oleksii Volodymyrovych  
Moskalenko, Pavlo Oleksandrovych  
Mohamad, Nasser
Tkach, Hennadii Fedorovych  
Keywords platelet-rich plasma
збагачена тромбоцитами плазми
обогащенная тромбоцитами плазма
chronic hyperglycemia
хронічна гіперглікемія
хроническая гипергликемия
Type Article
Date of Issue 2020
Publisher Hindawi
License Creative Commons Attribution 4.0 International License
Citation Raed Rtail, Olena Maksymova, Viacheslav Illiashenko, Olena Gortynska, Oleksii Korenkov, Pavlo Moskalenko, Mohamad Nasser, Gennadii Tkach, "Improvement of Skeletal Muscle Regeneration by Platelet-Rich Plasma in Rats with Experimental Chronic Hyperglycemia", BioMed Research International, vol. 2020, Article ID 6980607, 9 pages, 2020.
Abstract Herein, the structural effect of autologous platelet-rich plasma (PRP) on posttraumatic skeletal muscle regeneration in rats with chronic hyperglycemia (CH) was tested. 130 white laboratory male rats divided into four groups (I—control; II—rats with CH; III—rats with CH and PRP treatment; and IV—rats for CH confirmation) were used for the experiment. CH was simulated by streptozotocin and nicotinic acid administration. Triceps surae muscle injury was reproduced by transverse linear incision. Autologous PRP was used in order to correct the possible negative CH effect on skeletal muscle recovery. On the 28th day after the injury, the regenerating muscle fiber and blood vessel number in the CH+PRP group were higher than those in the CH rats. However, the connective tissue area in the CH group was larger than that in the CH+PRP animals. The amount of agranulocytes in the regenerating muscle of the CH rats was lower compared to that of the CH+PRP group. The histological analysis of skeletal muscle recovery in CH+PRP animals revealed more intensive neoangiogenesis compared to that in the CH group. Herewith, the massive connective tissue development and inflammation signs were observed within the skeletal muscle of CH rats. Obtained results suggest that streptozotocin-induced CH has a negative effect on posttraumatic skeletal muscle regeneration, contributing to massive connective tissue development. The autologous PRP injection promotes muscle recovery process in rats with CH, shifting it away from fibrosis toward the complete muscular organ repair.
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