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Title Immunoglobulin indicators to viruses cytomegal and genital herpes in the blood serum of women with non-atipical endometrial hyperprolifetative pathology
Authors Gorban, N.E.
Vovk, I.B.
Nikitina, Iryna Mykolaivna  
Kondratiuk, V.K.
Yemets, N.O.
Keywords non-atypical endometrial hyperproliferative pathology
non-atypical endometrial hyperplasia
uterine body polyp
immunoglobulin to cytomegalovirus and genital herpes viruses
Type Article
Date of Issue 2020
URI https://essuir.sumdu.edu.ua/handle/123456789/83199
Publisher Aluna Publishing
License Creative Commons Attribution 4.0 International License
Citation Gorban NE, Vovk IV, Nikitina IM et all. Immunoglobulin indicators to viruses cytomegal and genital herpes in the blood serum of women with non-atipical endometrial hyperprolifetative pathology. Wiadomosci lekarskie. 2020; 73(8): 1600–1604. DOI: 10.36740/WLek202008102
Abstract The aim of the study was to analyze the level of Ig M- and Ig G-antibody (Ab) for cytomegalovirus (CMV) and herpes simplex virus type 2 (HSV-2) in serum of women with non-atypical endometrial hyperproliferative pathology. Materials and methods: The analysis of immunoglobulin indices to CMV and HSV-2 in serum of women with non-atypical endometrial hyperproliferative pathology. In women with uterine body polyps the presence of CMV in the uterine cavity was found in 54.8% of cases, in women with non-atypical endometrial hyperplasia in 38.3% of cases. The levels of Ig G-Ab and Ig M-Ab to CMV in serum have a clear dependence on the degree of antigen expression in endometrial tissue. HSV-2 antigens were determined in 22.58 ± 5.31% of women with uterine body polyps and in 8.33 ± 3.57% of patients with non-atypical endometrial hyperplasia while increasing serum specific antibodies to HSV-2. Results: The results indicate that there is a clear link between viral infection of hyperproliferatively altered endometrium and the determination of positive immunoglobulin levels in peripheral blood, which may be a reliable marker of chronic persistent viral infection in a woman’s body. Conclusions: In women with uterine body polyps, the presence of CMV in the uterine cavity was found in 54.84 ± 6.32% of cases, in women with non-atypical endometrial hyperplasia in 38.33 ± 6.28% of cases. The levels of Ig G-Ab and and Ig M-Ab to CMV in serum have a clear dependence on the degree of antigen expression in endometrial tissue. HSV-2 antigens were determined in 22.58 ± 5.31% of women with uterine body polyps and in 8.33 ± 3.57% of patients with non-atypical endometrial hyperplasia while increasing serum specific antibodies to HSV-2. The results indicate that there is a clear link between viral infection of the target tissue (hyperproliferatively altered endometrium) and the determination of a positive level of peripheral blood immunoglobulin, which may be a reliable marker of chronic persistent viral infection in a woman.
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