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Title Bacterial protein domains with a novel Ig-like foldtarget human CEAC AM receptors
Authors Sorge, N.M.
Bonsor, D.A.
Deng, L.
Lindahl, E.
Schmitt, V.
Lyndin, Mykola Serhiiovych  
Schmidt, A.
Nilsson, O.R.
Brizuela, J.
Boero, E.
Sundberg, E.J.
Strijp, J.A.G.
Doran, K.S.
Singer, B.B.
Lindahl, G.
McCarth, A.J.
ORCID http://orcid.org/0000-0003-4385-3903
Keywords Adhesin
immunoglobulin superfamily
IgI
receptor
Streptococcus agalactiae
Type Article
Date of Issue 2021
URI https://essuir.sumdu.edu.ua/handle/123456789/83279
Publisher John Wiley and Sons
License Creative Commons Attribution 4.0 International License
Citation Sorge NM, Bonsor DA, Deng L, Lindahl E, Schmitt V, Lyndin MS, Schmidt A, Nilsson OR, Brizuela J, Boero E, Sundberg EJ, Strijp JAG, Doran KS, Singer BB, Lindahl G, McCarth A.J (2021) Bacterial protein domains with a novel Ig‐like fold target human CEACAM receptors The EMBO Journal 40: e106103. https://doi.org/10.15252/embj.2020106103
Abstract Streptococcus agalactiae, also known as group B Streptococcus (GBS), is the major cause of neonatal sepsis in humans. A critical step to infection is adhesion of bacteria to epithelial surfaces. GBS adhesins have been identified to bind extracellular matrix components and cellular receptors. However, several putative adhesins have no host binding partner characterised. We report here that surfaceexpressed b protein of GBS binds to human CEACAM1 and CEACAM5 receptors. A crystal structure of the complex showed that an IgSF domain in b represents a novel Ig-fold subtype called IgI3, in which unique features allow binding to CEACAM1. Bioinformatic assessment revealed that this newly identified IgI3 fold is not exclusively present in GBS but is predicted to be present in adhesins from other clinically important human pathogens. In agreement with this prediction, we found that CEACAM1 binds to an IgI3 domain found in an adhesin from a different streptococcal species. Overall, our results indicate that the IgI3 fold could provide a broadly applied mechanism for bacteria to target CEACAMs.
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