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Title Affinity Sensors for the Diagnosis of COVID-19
Authors Drobysh, M. M.
Ramanaviciene, A.
Viter, Roman Vitaliiovych
Ramanavicius, A.
Keywords COVID-19
SARS-CoV-2 virus
RNA analysis
bioelectrochemistry
biosensors
electrochemical immunosensors
antigen-antibody interaction
immune complex
molecularly imprinted polymers (MIPs)
surface modification by immobilization of biomolecule
Type Article
Date of Issue 2021
URI https://essuir.sumdu.edu.ua/handle/123456789/83787
Publisher MDPI
License Creative Commons Attribution 4.0 International License
Citation Drobysh, M.; Ramanaviciene, A.; Viter, R.; Ramanavicius, A. Affinity Sensors for the Diagnosis of COVID-19. Micromachines 2021, 12, 390. https://doi.org/10.3390/mi12040390
Abstract The coronavirus disease 2019 (COVID-19) outbreak caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was proclaimed a global pandemic in March 2020. Reducing the dissemination rate, in particular by tracking the infected people and their contacts, is the main instrument against infection spreading. Therefore, the creation and implementation of fast, reliable and responsive methods suitable for the diagnosis of COVID-19 are required. These needs can be fulfilled using affinity sensors, which differ in applied detection methods and markers that are generating analytical signals. Recently, nucleic acid hybridization, antigen-antibody interaction, and change of reactive oxygen species (ROS) level are mostly used for the generation of analytical signals, which can be accurately measured by electrochemical, optical, surface plasmon resonance, field-effect transistors, and some other methods and transducers. Electrochemical biosensors are the most consistent with the general trend towards, acceleration, and simplification of the bioanalytical process. These biosensors mostly are based on the determination of antigen-antibody interaction and are robust, sensitive, accurate, and sometimes enable label-free detection of an analyte. Along with the specification of biosensors, we also provide a brief overview of generally used testing techniques, and the description of the structure, life cycle and immune host response to SARS-CoV-2, and some deeper details of analytical signal detection principles.
Appears in Collections: Наукові видання (МІ)

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