Please use this identifier to cite or link to this item: https://essuir.sumdu.edu.ua/handle/123456789/84691
Or use following links to share this resource in social networks: Recommend this item
Title Hemostatic and Tissue Regeneration Performance of Novel Electrospun Chitosan-Based Materials
Authors Deineka, Volodymyr Mykolaiovych
Sulaieva, O.
Pernakov, Mykola Stanislavovych  
Korniienko, Viktoriia Volodymyrivna  
Husak, Yevheniia Volodymyrivna  
Yanovska, Hanna Oleksandrivna  
Yusupova, Aziza Farkhodivna
Tkachenko, Yuliia Anatoliivna  
Kalinkevich, O.
Zlatska, A.
Pohorielov, Maksym Volodymyrovych  
Keywords chitosan
electrospinning
hemostasis
regeneration
Type Article
Date of Issue 2021
URI https://essuir.sumdu.edu.ua/handle/123456789/84691
Publisher MDPI
License Creative Commons Attribution 4.0 International License
Citation Deineka, V.; Sulaieva, O.; Pernakov, M.; Korniienko, V.; Husak, Y.; Yanovska, A.; Yusupova, A.; Tkachenko, Y.; Kalinkevich, O.; Zlatska, A.; et al. Hemostatic andTissue Regeneration Performance of Novel Electrospun Chitosan-Based Materials. Biomedicines 2021, 9, 588. https://doi.org/10.3390/biomedicines9060588
Abstract The application of chitosan (Ch) as a promising biopolymer with hemostatic properties and high biocompatibility is limited due to its prolonged degradation time, which, in turn, slows the repair process. In the present research, we aimed to develop new technologies to reduce the biodegradation time of Ch-based materials for hemostatic application. This study was undertaken to assess the biocompatibility and hemostatic and tissue-regeneration performance of Ch-PEOcopolymer prepared by electrospinning technique. Chitosan electrospinning membranes (ChEsM) were made from Ch and polyethylene oxide (PEO) powders for rich high-porous material with sufficient hemostatic parameters. The structure, porosity, density, antibacterial properties, in vitro degradation and biocompatibility of ChEsM were evaluated and compared to the conventional Ch sponge (ChSp). In addition, the hemostatic and bioactive performance of both materials were examined in vivo, using the liver-bleeding model in rats. A penetrating punch biopsy of the left liver lobe was performed to simulate bleeding from a non-compressible irregular wound. Appropriately shaped ChSp or ChEsM were applied to tissue lesions. Electrospinning allows us to produce high-porous membranes with relevant ChSp degradation and swelling properties. Both materials demonstrated high biocompatibility and hemostatic effectiveness in vitro. However, the antibacterial properties of ChEsM were not as good when compared to the ChSp. In vivo studies confirmed superior ChEsM biocompatibility and sufficient hemostatic performance, with tight interplay with host cells and tissues. The in vivo model showed a higher biodegradation rate of ChEsM and advanced liver repair.
Appears in Collections: Наукові видання (МІ)

Views

Canada Canada
1
China China
12704914
Côte d’Ivoire Côte d’Ivoire
1
Germany Germany
17161296
Greece Greece
1
Ireland Ireland
3792149
Lithuania Lithuania
1
Netherlands Netherlands
288
Romania Romania
1
Sweden Sweden
1929
Ukraine Ukraine
90541
United Kingdom United Kingdom
101832566
United States United States
68077578
Unknown Country Unknown Country
1
Vietnam Vietnam
3860

Downloads

China China
1
Germany Germany
567602
Ireland Ireland
283803
Lithuania Lithuania
1
Singapore Singapore
1
South Africa South Africa
1
Switzerland Switzerland
1
Ukraine Ukraine
96
United Kingdom United Kingdom
1
United States United States
101832563
Vietnam Vietnam
1

Files

File Size Format Downloads
Deineka_et.al_Hemostatic_biomedicines.pdf 5,53 MB Adobe PDF 102684071

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.