Age-related features of hydroxyapatite structure in a spongy bone tissue

Abstract

The structure and size of hydroxyapatite depend on age. X-ray diffraction analysis helps to determine age-related features of hydroxyapatite structure in a spongy bone tissue. Comparing the obtained data with literature data (6,7,8), the ontogenetic transformations in spongy bone tissue can be divided into several periods: 1) period of intensive osteogenesis - in immature age; 2) stabilization period is in mature animals; 3) period of regressive changes with the predominance of resorption processes in old rats. The mineral component of the calcaneus matrix in laboratory rats of different age groups is characterized by changes at the microstructural level. An increasing in crystallite size rises the level of microdeformation of the crystal lattice. Defective increase, i.e. structural imperfection of biominerals, indicates violations of normal metabolic processes in the calcaneus, which in turn leads to a decrease in its strength.